World's Best Scientists 2026 revealed!
Ralf Hoffmann

Ralf Hoffmann

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
13664
World Ranking
9242
National Ranking
675

Overview

Ralf Hoffmann is affiliated with Leipzig University in Germany and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work spans a broad range of topics including antimicrobial peptides, RNA and protein synthesis mechanisms, and COVID-19 related research.

The scientist's recent publications illustrate a focus on antimicrobial peptides and their biological functions. Selected papers include:

  • Inhibition of translation termination by the antimicrobial peptide Drosocin, 2023, Nature Chemical Biology
  • Sensitive and specific serological ELISA for the detection of SARS-CoV-2 infections, 2022, Virology Journal
  • Sex-dependent dynamics of metabolism in primary mouse hepatocytes, 2021, Archives of Toxicology
  • Ribosomal Target-Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved among Pathogens Indicating New Lead Structures To Develop Novel Broad-Spectrum Antibiotics, 2020, ChemBioChem
  • The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the host-microbiome interaction, 2022, BMC Biology

Hoffmann's research covers several main topics, notably:

  • Antimicrobial Peptides and Activities
  • RNA and protein synthesis mechanisms
  • Advanced Glycation End Products research
  • Biochemical and Structural Characterization
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing

The subfields of study with significant publication counts include:

  • Molecular Biology
  • Infectious Diseases
  • Microbiology
  • Endocrinology, Diabetes and Metabolism
  • Spectroscopy

Frequent collaborators provide insight into Hoffmann's research network. Key co-authors are:

  • Daniela Volke
  • Andor Krizsan
  • Alexandra Brakel
  • Sanja Milkovska-Stamenova
  • Daniel Knappe

Hoffmann's contributions have appeared notably in several publication venues multiple times, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • ChemBioChem
  • Nature Communications
  • Antioxidants

Best Publications

  • The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding.

    Goran Kragol;Sandor Lovas;Gyorgyi Varadi;Barry A. Condie

  • Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies.

    Maria Fedorova;Ravi Chand Bollineni;Ralf Hoffmann

  • A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease.

    Gregory A. Jicha;Eric Lane;Inez Vincent;Laszlo Otvos

  • Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)

    Jingjing Xie;Sergey Reverdatto;Andrej Frolov;Ralf Hoffmann

  • Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.

    Anja Kunert;Josephine Losse;Christin Gruszin;Michael Hühn

  • Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum.

    Roland Böttger;Ralf Hoffmann;Daniel Knappe

  • Insect‐Derived Proline‐Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

    Andor Krizsan;Daniela Volke;Stefanie Weinert;Norbert Sträter

  • PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine.

    Jin-Hyung Lee;Jeffry R. Cook;Zhi-Hong Yang;Olga Mirochnitchenko

  • Advanced Glycation End Product Recognition by the Receptor for AGEs

    Jing Xue;Vivek Rai;David Singer;Stefan Chabierski

  • Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

    Ralf Hoffmann;Virginia M.-Y. Lee;Susan Leight;Istvan Varga

  • Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

    Laszlo Otvos;Eva Haspinger;Eva Haspinger;Francesca La Russa;Francesca La Russa;Federica Maspero;Federica Maspero

  • Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains

    Jennifer Ebner;Ayşe Aşçı Arslan;Maria Fedorova;Ralf Hoffmann

  • FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues.

    Jeffry R. Cook;Jin-Hyung Lee;Zhi-Hong Yang;Christopher D. Krause

  • Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen

    Hermann Ehrlich;Rainer Deutzmann;Eike Brunner;Enrico Cappellini

  • Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin.

    Goran Kragol;Ralf Hoffmann;Michael A. Chattergoon;Sandor Lovas

  • The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

    Jing Xue;Rashmi Ray;David Singer;David Böhme

  • Amino acid analysis by hydrophilic interaction chromatography coupled on-line to electrospray ionization mass spectrometry.

    T. Langrock;P. Czihal;R. Hoffmann

  • Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

    Robert Porzig;David Singer;Ralf Hoffmann

  • Spectroscopic and molecular characterization of the oligomeric antenna of the diatom Phaeodactylum tricornutum

    Bernard Lepetit;Daniela Volke;Milán Szabó;Ralf Hoffmann

  • Mineralization of the meter-long biosilica structures of glass sponges is templated on hydroxylated collagen.

    H. Ehrlich;R. Deutzmann;E. Capellini;H. Koon

Frequent Co-Authors

Laszlo Otvos
Laszlo Otvos Semmelweis University
John D. Wade
John D. Wade Florey Institute of Neuroscience and Mental Health
Norbert Sträter
Norbert Sträter Leipzig University
Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Matthias Blüher
Matthias Blüher Leipzig University
David J. Craik
David J. Craik University of Queensland
Hildegund C. J. Ertl
Hildegund C. J. Ertl The Wistar Institute
Jürgen Schiller
Jürgen Schiller Leipzig University
Hans Robert Kalbitzer
Hans Robert Kalbitzer University of Regensburg
Hermann Ehrlich
Hermann Ehrlich TU Bergakademie Freiberg

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