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Biology and Biochemistry

D-Index
44
Citations
6415
World Ranking
19317
National Ranking
618

Overview

Marco Scocchi is affiliated with the University of Trieste in Italy and conducts research primarily in the fields of Immunology and Microbiology as well as Biochemistry, Genetics and Molecular Biology. Their work extensively covers subfields such as Molecular Biology, Microbiology, Immunology, Genetics, and Ecology.

Their research focuses significantly on topics related to Antimicrobial Peptides and Activities, including biochemical and structural characterization, RNA and protein synthesis mechanisms, protein hydrolysis and bioactive peptides, invertebrate immune response mechanisms, bacteriophages and microbial interactions, and immune response and inflammation.

Marco Scocchi has contributed to numerous publications, with selected recent papers including:

  • Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens (2020), Journal of Medicinal Chemistry
  • Effects of Lipidation on a Proline-Rich Antibacterial Peptide (2021), International Journal of Molecular Sciences
  • Natural and Synthetic Halogenated Amino Acids-Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics (2021), Molecules
  • Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens (2020), International Journal of Molecular Sciences
  • Designing New Hybrid Antibiotics: Proline-Rich Antimicrobial Peptides Conjugated to the Aminoglycoside Tobramycin (2023), Bioconjugate Chemistry

Frequent publication venues for their research include:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Molecules
  • Bioconjugate Chemistry

Marco Scocchi collaborates frequently with several researchers, with coauthors including Mario Mardirossian, Adriana Di Stasi, Daniel N. Wilson, Sabrina Pacor, and Martino Morici. These partnerships have produced multiple publications advancing the understanding of antimicrobial peptides and related molecular mechanisms.

Best Publications

  • The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator.

    Daniela Xhindoli;Sabrina Pacor;Monica Benincasa;Marco Scocchi

  • Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

    Marco Scocchi;Alessandro Tossi;Renato Gennaro

  • Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides.

    Maura Mattiuzzo;Antonella Bandiera;Renato Gennaro;Monica Benincasa

  • Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria.

    Marco Scocchi;Mario Mardirossian;Giulia Runti;Monica Benincasa

  • The Host Antimicrobial Peptide Bac71-35 Binds to Bacterial Ribosomal Proteins and Inhibits Protein Synthesis

    Mario Mardirossian;Renata Grzela;Carmela Giglione;Thierry Meinnel

  • Structure and Biology of Cathelicidins

    Margherita Zanetti;Renato Gennaro;Marco Scocchi;Barbara Skerlavaj

  • Proline-rich antimicrobial peptides targeting protein synthesis

    Michael Graf;Mario Mardirossian;Fabian Nguyen;A. Carolin Seefeldt

  • Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins.

    Marco Scocchi;Barbara Skerlavaj;Domenico Romeo;Renato Gennaro

  • Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts

    Monica Benincasa;Marco Scocchi;Sabrina Pacor;Alessandro Tossi

  • Dual mode of action of Bac7, a proline-rich antibacterial peptide.

    Elena Podda;Monica Benincasa;Sabrina Pacor;Fulvio Micali

  • cDNA sequences of three sheep myeloid cathelicidins.

    Luigi Bagella;Marco Scocchi;Margherita Zanetti;Margherita Zanetti

  • Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients

    A. Pompilio;Marco Scocchi;S. Pomponio;F. Guida

  • PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.

    Alessandro Tossi;Marco Scocchi;Margherita Zanetti;Paola Storici

  • Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA.

    Paola Storici;Paola Storici;Marco Scocchi;Alessandro Tossi;Renato Gennaro

  • Structural organization of the bovine cathelicidin gene family and identification of a novel member1

    Marco Scocchi;Marco Scocchi;Shenglun Wang;Margherita Zanetti;Margherita Zanetti

  • Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes

    Alessandro Tossi;Marco Scocchi;Barbara Skerlavaj;Renato Gennaro

  • Structure of the mammalian antimicrobial peptide Bac7(1–16) bound within the exit tunnel of a bacterial ribosome

    A. Carolin Seefeldt;A. Carolin Seefeldt;A. Carolin Seefeldt;Michael Graf;Natacha Pérébaskine;Natacha Pérébaskine;Natacha Pérébaskine;Fabian Nguyen

  • Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells

    Margherita Zanetti;P Storici;Alessandro Tossi;Marco Scocchi

  • Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed α-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia

    Arianna Pompilio;Valentina Crocetta;Marco Scocchi;Stefano Pomponio

  • Antimicrobial activity of Bac7 fragments against drug-resistant clinical isolates.

    Monica Benincasa;Marco Scocchi;Elena Podda;Barbara Skerlavaj

Frequent Co-Authors

Renato Gennaro
Renato Gennaro University of Trieste
Margherita Zanetti
Margherita Zanetti University of Udine
Alessandro Tossi
Alessandro Tossi University of Trieste
Daniel N. Wilson
Daniel N. Wilson Universität Hamburg
Euan K. James
Euan K. James James Hutton Institute
Clifton E. Barry
Clifton E. Barry National Institute of Allergy and Infectious Diseases
Timothy J. Mitchell
Timothy J. Mitchell University of Birmingham
Helena I. Boshoff
Helena I. Boshoff National Institutes of Health
Vasil M. Garamus
Vasil M. Garamus Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research

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