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Microbiology

D-Index
65
Citations
16789
World Ranking
2493
National Ranking
1012

Overview

Helena I. Boshoff is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on tuberculosis, biochemistry, genetics, and molecular biology, with a substantial number of publications in these areas.

The main fields of study for Boshoff include Medicine and Biochemistry, Genetics, and Molecular Biology, with further specialization in the subfields of Molecular Biology, Infectious Diseases, Epidemiology, Organic Chemistry, and Pharmacology.

The scientist's research covers key topics such as Tuberculosis Research and Epidemiology, Biochemical and Molecular Research, Mycobacterium research and diagnosis, Cancer therapeutics and mechanisms, Synthesis and biological activity, Quinazolinone synthesis and applications, and Microbial Natural Products and Biosynthesis.

Frequent coauthors working with Boshoff include Clifton E. Barry, Paul G. Wyatt, Sangmi Oh, Thomas R. Ioerger, and Simon R. Green.

Regular publication venues for Boshoff feature journals like ACS Infectious Diseases, Journal of Medicinal Chemistry, bioRxiv (Cold Spring Harbor Laboratory), European Journal of Medicinal Chemistry, and Antimicrobial Agents and Chemotherapy.

Selected recent papers authored or coauthored by Boshoff include:

  • PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis, 2020, Science
  • The Tuberculosis Drug Accelerator at year 10: what have we learned?, 2021, Nature Medicine
  • Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets, 2021, Frontiers in Cellular and Infection Microbiology
  • GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment, 2022, Antimicrobial Agents and Chemotherapy
  • Identification of Antifungal Compounds against Multidrug-Resistant Candida auris Utilizing a High-Throughput Drug-Repurposing Screen, 2021, Antimicrobial Agents and Chemotherapy

Best Publications

  • The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

    Clifton E. Barry;Helena I. Boshoff;Véronique Dartois;Thomas Dick

  • PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

    Ramandeep Singh;Ujjini Manjunatha;Ujjini Manjunatha;Helena I. M. Boshoff;Young Hwan Ha

  • The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.

    Helena I.M. Boshoff;Timothy G. Myers;Brent R. Copp;Michael R. McNeil

  • Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

    Jean Emmanuel Hugonnet;Lee W. Tremblay;Helena I. Boshoff;Clifton E. Barry

  • Tuberculosis — metabolism and respiration in the absence of growth

    Helena I. M. Boshoff;Clifton E. Barry

  • SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

    Kapil Tahlan;Regina Wilson;David B. Kastrinsky;Kriti Arora

  • DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis

    Helena I.M. Boshoff;Helena I.M. Boshoff;Michael B. Reed;Clifton E. Barry;Valerie Mizrahi

  • The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.

    John L. Dahl;Carl N. Kraus;Helena I. M. Boshoff;Bernard Doan

  • Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

    Ujjini H. Manjunatha;Helena Boshoff;Cynthia S. Dowd;Liang Zhang

  • The mechanism of action of PA-824: Novel insights from transcriptional profiling.

    Ujjini Manjunatha;Helena I.M. Boshoff;Clifton E. Barry

  • Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.

    Kristine B Arnvig;Iñaki Comas;Nicholas R. Thomson;Joanna Houghton

  • Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.

    Pradeep Kumar;Kriti Arora;John R. Lloyd;Ill Young Lee

  • Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

    Thomas R. Ioerger;Theresa O’Malley;Reiling Liao;Kristine M. Guinn

  • Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

    Shinya Watanabe;Michael Zimmermann;Michael B. Goodwin;Uwe Sauer

  • Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

    Keriann M Backus;Keriann M Backus;Helena I Boshoff;Conor S Barry;Omar Boutureira

  • Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

    Unknown

  • Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis

    Sumit Chakraborty;Todd Gruber;Clifton E. Barry;Helena I. Boshoff

  • Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.

    Jansy P Sarathy;Laura E Via;Laura E Via;Danielle Weiner;Landry Blanc

  • Advent of imidazo[1,2-a]pyridine-3-carboxamides with potent multi- and extended drug resistant antituberculosis activity

    Garrett C. Moraski;Lowell D. Markley;Philip A. Hipskind;Helena Boshoff

  • Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

    Richard E Lee;Julian G Hurdle;Jiuyu Liu;David F Bruhn

  • Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I

    Helena I. Boshoff;Valerie Mizrahi;Clifton E. Barry

  • Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI

    Helena I.M. Boshoff;Xia Xu;Kapil Tahlan;Cynthia S. Dowd

Frequent Co-Authors

Clifton E. Barry
Clifton E. Barry National Institute of Allergy and Infectious Diseases
Dirk Schnappinger
Dirk Schnappinger Cornell University
Thomas Dick
Thomas Dick Georgetown University
Laura E. Via
Laura E. Via National Institutes of Health
Chris Abell
Chris Abell University of Cambridge
Kyu Y. Rhee
Kyu Y. Rhee Cornell University
Daniel J. Wilson
Daniel J. Wilson University of Oxford
Tom L. Blundell
Tom L. Blundell University of Cambridge
Sabine Ehrt
Sabine Ehrt Cornell University
Marvin J. Miller
Marvin J. Miller University of Notre Dame

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