Helena I. Boshoff focuses on Mycobacterium tuberculosis, Biochemistry, Microbiology, Tuberculosis and Drug resistance. Her Mycobacterium tuberculosis research includes themes of In vitro, Mechanism of action, Microarray analysis techniques, Immunology and Gene. Her Biochemistry study deals with SQ109 intersecting with Nitroimidazole, Reactive nitrogen species, Intracellular, Primary metabolite and Nitroreductase.
The concepts of her Microbiology study are interwoven with issues in Heat shock protein and Bacterial genetics. Helena I. Boshoff has researched Tuberculosis in several fields, including Microorganism, Metabolism, Bacterial growth and Microbial metabolism. Her Drug resistance research includes themes of Polymerase and Pharmacology.
Her primary scientific interests are in Mycobacterium tuberculosis, Biochemistry, Microbiology, Stereochemistry and Enzyme. Her Mycobacterium tuberculosis research is within the category of Tuberculosis. Her Tuberculosis study combines topics from a wide range of disciplines, such as Drug tolerance, Disease, Immunology and Intensive care medicine.
The concepts of her Microbiology study are interwoven with issues in Bacteria and Mutant, Gene, Virulence. The Stereochemistry study combines topics in areas such as Nitroreductase, Structure–activity relationship, Antibacterial agent and Antimycobacterial. Her work in Pharmacology addresses subjects such as Drug resistance, which are connected to disciplines such as Potency.
Mycobacterium tuberculosis, Biochemistry, In vitro, Stereochemistry and Drug discovery are her primary areas of study. Her Mycobacterium tuberculosis study is focused on Tuberculosis in general. Her Tuberculosis research is multidisciplinary, incorporating elements of Pharmacophore, Drug target, Small Molecule Libraries and Computational biology.
Her research integrates issues of Antimycobacterial, Antimycobacterial Agents and Resistant tuberculosis in her study of Stereochemistry. The study incorporates disciplines such as Multiple drug resistance and Protein biosynthesis in addition to Drug discovery. Her work carried out in the field of Microbiology brings together such families of science as Drug repositioning and Virulence.
Helena I. Boshoff mainly focuses on Mycobacterium tuberculosis, Microbiology, Biochemistry, Mycobacterium abscessus and Stereochemistry. Helena I. Boshoff performs multidisciplinary study in Mycobacterium tuberculosis and Combination chemotherapy in her work. Her Microbiology study frequently draws connections between adjacent fields such as Virulence.
Helena I. Boshoff works mostly in the field of Mycobacterium abscessus, limiting it down to topics relating to Transfer RNA and, in certain cases, Nontuberculous mycobacteria and Bacteria, as a part of the same area of interest. Helena I. Boshoff combines subjects such as Mechanism of action, Biotin synthase, Acidomycin, Biotin biosynthesis and Antimycobacterial with her study of Stereochemistry. Her Pathogen research incorporates themes from Oxidase test, Drug development, Respiratory chain and Tuberculosis.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Clifton E. Barry;Helena I. Boshoff;Véronique Dartois;Thomas Dick.
Nature Reviews Microbiology (2009)
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.
Helena I.M. Boshoff;Timothy G. Myers;Brent R. Copp;Michael R. McNeil.
Journal of Biological Chemistry (2004)
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Ramandeep Singh;Ujjini Manjunatha;Ujjini Manjunatha;Helena I. M. Boshoff;Young Hwan Ha.
Tuberculosis — metabolism and respiration in the absence of growth
Helena I. M. Boshoff;Clifton E. Barry.
Nature Reviews Microbiology (2005)
Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
Jean Emmanuel Hugonnet;Lee W. Tremblay;Helena I. Boshoff;Clifton E. Barry.
SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Kapil Tahlan;Regina Wilson;David B. Kastrinsky;Kriti Arora.
Antimicrobial Agents and Chemotherapy (2012)
DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis
Helena I.M. Boshoff;Helena I.M. Boshoff;Michael B. Reed;Clifton E. Barry;Valerie Mizrahi.
The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.
John L. Dahl;Carl N. Kraus;Helena I. M. Boshoff;Bernard Doan.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
Ujjini H. Manjunatha;Helena Boshoff;Cynthia S. Dowd;Liang Zhang.
Proceedings of the National Academy of Sciences of the United States of America (2006)
The mechanism of action of PA-824: Novel insights from transcriptional profiling.
Ujjini Manjunatha;Helena I.M. Boshoff;Clifton E. Barry.
Communicative & Integrative Biology (2009)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: