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Dirk Schnappinger

Dirk Schnappinger

D-Index & Metrics

Microbiology

D-Index
64
Citations
19368
World Ranking
2576
National Ranking
1037

Overview

Dirk Schnappinger is affiliated with Cornell University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Infectious Diseases, Molecular Biology, Epidemiology, Organic Chemistry, and Molecular Medicine.

The scientist's main topics of work include:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Cancer therapeutics and mechanisms
  • Biochemical and Molecular Research
  • RNA and protein synthesis mechanisms
  • Antibiotic Resistance in Bacteria
  • Computational Drug Discovery Methods

Schnappinger has published extensively, with recent papers including:

  • Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis, 2021, Cell
  • CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis, 2022, Nature Microbiology
  • Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis, 2020, EMBO Molecular Medicine
  • The Tuberculosis Drug Accelerator at year 10: what have we learned?, 2021, Nature Medicine
  • CinA mediates multidrug tolerance in Mycobacterium tuberculosis, 2022, Nature Communications

Frequent coauthors in Schnappinger's work include:

  • Sabine Ehrt
  • Curtis A. Engelhart
  • Kyu Y. Rhee
  • Véronique Dartois
  • Joshua B. Wallach

The scientist's publications appear regularly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Nature Communications
  • ACS Infectious Diseases
  • Nature Microbiology

Best Publications

  • Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages Insights into the Phagosomal Environment

    Dirk Schnappinger;Sabine Ehrt;Martin I. Voskuil;Yang Liu

  • The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

    Clifton E. Barry;Helena I. Boshoff;Véronique Dartois;Thomas Dick

  • Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program

    Martin I. Voskuil;Dirk Schnappinger;Kevin C. Visconti;Maria I. Harrell

  • Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

    David R. Sherman;Martin Voskuil;Dirk Schnappinger;Reiling Liao

  • Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis Signaling Roles of Nitric Oxide Synthase-2 and Phagocyte Oxidase

    Sabine Ehrt;Dirk Schnappinger;Stefan Bekiranov;Jorg Drenkow

  • Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

    Michael A. DeJesus;Elias R. Gerrick;Weizhen Xu;Sae Woong Park

  • Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system.

    Peter Orth;Dirk Schnappinger;Wolfgang Hillen;Wolfram Saenger

  • Tetracyclines: antibiotic action, uptake, and resistance mechanisms.

    Dirk Schnappinger;W. Hillen

  • Mycobacterial survival strategies in the phagosome: defence against host stresses

    Sabine Ehrt;Dirk Schnappinger

  • Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

    Jeremy M. Rock;Forrest F. Hopkins;Alejandro Chavez;Alejandro Chavez;Marieme Diallo

  • Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

    Joeli Marrero;Kyu Y. Rhee;Dirk Schnappinger;Kevin Pethe

  • Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

    Sabine Ehrt;Xinzheng V. Guo;Christopher M. Hickey;Marvin Ryou

  • A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.

    Omar H Vandal;Lynda M Pierini;Dirk Schnappinger;Carl F Nathan

  • Ancestral antibiotic resistance in Mycobacterium tuberculosis.

    Rowan P. Morris;Liem Nguyen;John Gatfield;Kevin Visconti

  • Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

    Barbara Bosch;Michael A. DeJesus;Nicholas C. Poulton;Wenzhu Zhang

  • Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

    Sabine Ehrt;Dirk Schnappinger;Kyu Y. Rhee

  • In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

    Sheetal Gandotra;Dirk Schnappinger;Mercedes Monteleone;Wolfgang Hillen

  • CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

    Unknown

  • Depletion of antibiotic targets has widely varying effects on growth

    Jun-Rong Wei;Vidhya Krishnamoorthy;Kenan Murphy;Jee-Hyun Kim

  • MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis

    Shuangping Shi;Carl Nathan;Dirk Schnappinger;Jörg Drenkow

  • Regulation of the Mycobacterium tuberculosis PE/PPE genes.

    M.I. Voskuil;M.I. Voskuil;D. Schnappinger;R. Rutherford;Y. Liu

Frequent Co-Authors

Sabine Ehrt
Sabine Ehrt Cornell University
Kyu Y. Rhee
Kyu Y. Rhee Cornell University
Wolfgang Hillen
Wolfgang Hillen University of Erlangen-Nuremberg
Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
Helena I. Boshoff
Helena I. Boshoff National Institutes of Health
Christopher M. Sassetti
Christopher M. Sassetti University of Massachusetts Chan Medical School
Clifton E. Barry
Clifton E. Barry National Institute of Allergy and Infectious Diseases
Eric J. Rubin
Eric J. Rubin Harvard University
Gary K. Schoolnik
Gary K. Schoolnik Stanford University
Carl Nathan
Carl Nathan Cornell University

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