His primary areas of investigation include Genetics, Gene, Mycobacterium tuberculosis, Genome and Mutant. His studies link Secretion with Gene. His Mycobacterium tuberculosis research integrates issues from Antibiotic sensitivity, Biochemistry, Metabolic pathway and Microbiology.
His Genome research incorporates themes from Mutagenesis and Frameshift mutation. His Mutagenesis study incorporates themes from Pathogen and Deep sequencing. His Mutant research includes elements of Secretory protein, Proteomics, Bacterial genetics, Locus and Virulence.
Christopher M. Sassetti focuses on Mycobacterium tuberculosis, Tuberculosis, Biochemistry, Gene and Genetics. His Mycobacterium tuberculosis study combines topics in areas such as Pathogen, Antibiotics, Microbiology, Immune system and Computational biology. In his study, which falls under the umbrella issue of Tuberculosis, Public health is strongly linked to Immunology.
Christopher M. Sassetti studied Biochemistry and Mycobacterium smegmatis that intersect with Cell biology. Genetics is represented through his Genome, Mutagenesis and Minimal genome research. The concepts of his Mutant study are interwoven with issues in Secretory protein and Virulence.
Christopher M. Sassetti mainly focuses on Mycobacterium tuberculosis, Tuberculosis, Cell biology, Gene and Immunology. His Mycobacterium tuberculosis study combines topics from a wide range of disciplines, such as Genetics, Pathogen, Microbiology, T cell and Drug discovery. His work carried out in the field of Tuberculosis brings together such families of science as Efficacy, Antibiotics, In vivo and Vaccination.
The various areas that Christopher M. Sassetti examines in his Cell biology study include Cell wall, SIRT3, Metabolic pathway and Mycobacterium smegmatis. He works mostly in the field of Gene, limiting it down to topics relating to Cytokinesis and, in certain cases, Regulation of gene expression and Transcriptome. His Immunity and BCG vaccine study, which is part of a larger body of work in Immunology, is frequently linked to Bone marrow suppression, Linezolid and Intradermal route, bridging the gap between disciplines.
Tuberculosis, Mycobacterium tuberculosis, Immunology, Antibiotics and Drug resistance are his primary areas of study. The Tuberculosis study combines topics in areas such as T cell, Immunopathology, Granulocyte and Microbiology. Many of his studies on Mycobacterium tuberculosis involve topics that are commonly interrelated, such as Intracellular.
Many of his research projects under Immunology are closely connected to Hematopoietic stem cell with Hematopoietic stem cell, tying the diverse disciplines of science together. His research in Antibiotics intersects with topics in Gene and Genetic screen. His Gene research includes themes of In vivo, Efficacy, Combination therapy, Isoniazid and Drug discovery.
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Genes required for mycobacterial growth defined by high density mutagenesis
Christopher M. Sassetti;Dana H. Boyd;Eric J. Rubin.
Molecular Microbiology (2003)
Genetic requirements for mycobacterial survival during infection
Christopher M. Sassetti;Eric J. Rubin.
Proceedings of the National Academy of Sciences of the United States of America (2003)
High-resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism
Jennifer E. Griffin;Jeffrey D. Gawronski;Michael A. DeJesus;Thomas R. Ioerger.
PLOS Pathogens (2011)
Mycobacterial persistence requires the utilization of host cholesterol
Amit K. Pandey;Christopher M. Sassetti.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Comprehensive identification of conditionally essential genes in mycobacteria
Christopher M. Sassetti;Dana H. Boyd;Eric J. Rubin.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Bibhuti B Mishra;Vijay A K Rathinam;Gregory W Martens;Amanda J Martinot.
Nature Immunology (2013)
Mutually dependent secretion of proteins required for mycobacterial virulence
S. M. Fortune;A. Jaeger;D. A. Sarracino;M. R. Chase.
Proceedings of the National Academy of Sciences of the United States of America (2005)
RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.
J Clever;C Sassetti;T G Parslow.
Journal of Virology (1995)
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.
Michael A. DeJesus;Elias R. Gerrick;Weizhen Xu;Sae Woong Park.
Identification of Podocalyxin-like Protein as a High Endothelial Venule Ligand for L-selectin: Parallels to CD34
Christopher Sassetti;Kirsten Tangemann;Mark S. Singer;David B. Kershaw.
Journal of Experimental Medicine (1998)
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