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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
22291
World Ranking
8982
National Ranking
3991

Overview

Christopher M. Sassetti is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on topics within medicine and biochemistry, genetics, and molecular biology. The scientist has contributed extensively to the fields of infectious diseases, immunology, and epidemiology, along with molecular biology and genetics.

The core areas of Christopher M. Sassetti's work include:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Immune responses and vaccinations

Frequent coauthors who have collaborated with Sassetti include Clare M. Smith, Kadamba Papavinasasundaram, Thomas R. Ioerger, Megan K. Proulx, and Andrew J. Olive.

Sassetti has published research in various scientific venues, with numerous contributions to bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, The Journal of Immunology, OPAL (Open@LaTrobe) (La Trobe University), and Nature Communications. These publications indicate a broad engagement with both preprint and peer-reviewed journals relevant to infectious diseases and molecular biology.

Selected recent papers authored by Christopher M. Sassetti include:

  • M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity, 2020, Cell
  • Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research, 2020, Genetics
  • Granulocytes act as a niche for Mycobacterium tuberculosis growth, 2020, Mucosal Immunology
  • CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis, 2020, PLoS Pathogens
  • Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis, 2020, mSystems

Best Publications

  • Genes required for mycobacterial growth defined by high density mutagenesis

    Christopher M. Sassetti;Dana H. Boyd;Eric J. Rubin

  • Genetic requirements for mycobacterial survival during infection

    Christopher M. Sassetti;Eric J. Rubin

  • High-resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

    Jennifer E. Griffin;Jeffrey D. Gawronski;Michael A. DeJesus;Thomas R. Ioerger

  • Mycobacterial persistence requires the utilization of host cholesterol

    Amit K. Pandey;Christopher M. Sassetti

  • Comprehensive identification of conditionally essential genes in mycobacteria

    Christopher M. Sassetti;Dana H. Boyd;Eric J. Rubin

  • Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

    Michael A. DeJesus;Elias R. Gerrick;Weizhen Xu;Sae Woong Park

  • Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.

    Bibhuti B Mishra;Vijay A K Rathinam;Gregory W Martens;Amanda J Martinot

  • Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

    Jeremy M. Rock;Forrest F. Hopkins;Alejandro Chavez;Alejandro Chavez;Marieme Diallo

  • Mutually dependent secretion of proteins required for mycobacterial virulence

    S. M. Fortune;A. Jaeger;D. A. Sarracino;M. R. Chase

  • RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.

    J Clever;C Sassetti;T G Parslow

  • NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.

    Amit K. Pandey;Yibin Yang;Zhaozhao Jiang;Sarah Merritt Fortune

  • Identification of Podocalyxin-like Protein as a High Endothelial Venule Ligand for L-selectin: Parallels to CD34

    Christopher Sassetti;Kirsten Tangemann;Mark S. Singer;David B. Kershaw

  • Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

    Seung-Hun Baek;Alice H. Li;Christopher M. Sassetti;Christopher M. Sassetti

  • The normalcy of dormancy: common themes in microbial quiescence.

    Emily S.C. Rittershaus;Seung-Hun Baek;Christopher M. Sassetti;Christopher M. Sassetti

  • Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.

    Bibhuti B. Mishra;Rustin R. Lovewell;Andrew J. Olive;Guoliang Zhang

  • Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.

    Jennifer E. Griffin;Amit K. Pandey;Sarah A. Gilmore;Valerie Mizrahi

  • Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide.

    François Coulombe;Maziar Divangahi;Frédéric J. Veyrier;Louis de Léséleuc

  • Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

    Thomas R. Ioerger;Theresa O’Malley;Reiling Liao;Kristine M. Guinn

  • Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories

    Thomas R. Ioerger;Yicheng Feng;Krishna Ganesula;Xiaohua Chen

  • NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2

    Yibin Yang;Catherine C. Yin;Amit K. Pandey;Derek Abbott

Frequent Co-Authors

Eric J. Rubin
Eric J. Rubin Harvard University
Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
Richard Baker
Richard Baker University of Leicester
Sarah M. Fortune
Sarah M. Fortune Harvard University
Samuel M. Behar
Samuel M. Behar University of Massachusetts Chan Medical School
Dirk Schnappinger
Dirk Schnappinger Cornell University
Sabine Ehrt
Sabine Ehrt Cornell University
James C. Sacchettini
James C. Sacchettini Texas A&M University
Steven D. Rosen
Steven D. Rosen University of California, San Francisco
Deborah T. Hung
Deborah T. Hung Harvard University

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