D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 13,406 348 World Ranking 6304 National Ranking 166

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

Peptide, Biochemistry, Internal medicine, Endocrinology and Receptor are his primary areas of study. His study in Peptide is interdisciplinary in nature, drawing from both Amino acid, Peptide sequence, Stereochemistry and P3 peptide. His study ties his expertise on Neurodegeneration together with the subject of Biochemistry.

His study on Gonadotropin and Calorie restriction is often connected to Orexigenic and Glucagon-like peptide-1 as part of broader study in Endocrinology. His Receptor study incorporates themes from Cerebral cortex, Biological activity and Uterus. John D. Wade interconnects Combinatorial chemistry and Solid-phase synthesis in the investigation of issues within Peptide synthesis.

His most cited work include:

  • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 (858 citations)
  • INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent (353 citations)
  • Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. (315 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Peptide, Biochemistry, Relaxin, Receptor and Relaxin/insulin-like family peptide receptor 2. His Peptide research incorporates themes from Amino acid, Peptide sequence, Stereochemistry and Protein structure. His studies deal with areas such as Protein secondary structure and Circular dichroism as well as Peptide sequence.

Combinatorial chemistry is closely connected to Solid-phase synthesis in his research, which is encompassed under the umbrella topic of Stereochemistry. Within the field of Internal medicine and Endocrinology John D. Wade studies Relaxin. The concepts of his Receptor study are interwoven with issues in Molecular biology and Cell biology.

He most often published in these fields:

  • Peptide (60.10%)
  • Biochemistry (43.27%)
  • Relaxin (33.17%)

What were the highlights of his more recent work (between 2014-2021)?

  • Peptide (60.10%)
  • Biochemistry (43.27%)
  • Combinatorial chemistry (13.70%)

In recent papers he was focusing on the following fields of study:

John D. Wade spends much of his time researching Peptide, Biochemistry, Combinatorial chemistry, Stereochemistry and Peptide synthesis. His research integrates issues of Amino acid, Chemical synthesis and Relaxin, Relaxin/insulin-like family peptide receptor 2 in his study of Peptide. His Relaxin/insulin-like family peptide receptor 2 research is included under the broader classification of Receptor.

His Receptor study combines topics from a wide range of disciplines, such as Protein structure and Cell biology. His work carried out in the field of Biochemistry brings together such families of science as Dimer and Insulin receptor. His Stereochemistry study combines topics in areas such as Supramolecular chemistry, Relaxin-3 and Organic chemistry.

Between 2014 and 2021, his most popular works were:

  • A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1 (41 citations)
  • A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1 (41 citations)
  • Relaxin family peptides: structure-activity relationship studies. (40 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

His primary areas of study are Peptide, Biochemistry, Agonist, Stereochemistry and Receptor. John D. Wade studies Peptide, focusing on Peptide synthesis in particular. His study in the field of Membrane, Circular dichroism, Residue and Antimicrobial peptides also crosses realms of Monomer.

His biological study deals with issues like Endocrinology, which deal with fields such as FG-7142 and Antagonist. His Stereochemistry research is multidisciplinary, incorporating elements of Peptide sequence and Solid-phase synthesis. His research related to Relaxin/insulin-like family peptide receptor 2 and Relaxin receptor might be considered part of Receptor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

Maria Rozakis-Adcock;Ross Fernley;John Wade;Tony Pawson;Tony Pawson.
Nature (1993)

1289 Citations

INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent

Jin Kumagai;Sheau Yu Hsu;Hirotaka Matsumi;Jae-Sook Roh.
Journal of Biological Chemistry (2002)

426 Citations

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family.

Ross A.D. Bathgate;Chrishan S. Samuel;Tanya C.D. Burazin;Sharon Layfield.
Journal of Biological Chemistry (2002)

414 Citations

Paracrine regulation of mammalian oocyte maturation and male germ cell survival.

Kazuhiro Kawamura;Jin Kumagai;Satoko Sudo;Sang-Young Chun.
Proceedings of the National Academy of Sciences of the United States of America (2004)

365 Citations

Amyloid- Peptide (A ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A Dimers and Trimers Correlate with Neurotoxicity

Lin Wai Hung;Giuseppe D Ciccotosto;Eleni Giannakis;Deborah J Tew.
The Journal of Neuroscience (2008)

242 Citations

Neurotoxic, Redox-competent Alzheimer's β-Amyloid Is Released from Lipid Membrane by Methionine Oxidation

Kevin J. Barnham;Giuseppe D. Ciccotosto;Anna K. Tickler;Anna K. Tickler;Feda E. Ali.
Journal of Biological Chemistry (2003)

236 Citations

Current challenges in peptide-based drug discovery

Laszlo Otvos;John D. Wade.
Frontiers in Chemistry (2014)

231 Citations

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

D P Smith;D P Smith;Danielle G Smith;Danielle G Smith;Cyril C Curtain;Cyril C Curtain;Cyril C Curtain;John Frank Boas.
Journal of Biological Chemistry (2006)

213 Citations

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.

Longwen Deng;Cynthia de la Fuente;Peng Fu;Lai Wang.
Virology (2000)

209 Citations

DBU as an N alpha-deprotecting reagent for the fluorenylmethoxycarbonyl group in continuous flow solid-phase peptide synthesis.

J D Wade;J Bedford;R C Sheppard;G W Tregear.
Peptide research (1991)

181 Citations

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