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Genetics

D-Index
52
Citations
36739
World Ranking
3745
National Ranking
1612

Overview

Prashant Mali is a researcher affiliated with the University of California, San Diego in the United States. Their work primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a significant emphasis on Molecular Biology as a subfield. Additional areas of specialization include Genetics, Cardiology and Cardiovascular Medicine, Cancer Research, and Biophysics.

Throughout their career, Mali has contributed extensively to topics including:

  • CRISPR and Genetic Engineering
  • RNA regulation and disease
  • Single-cell and spatial transcriptomics
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • Pluripotent Stem Cells Research
  • Viral Infections and Immunology Research

Their recent publications reflect a strong concentration on RNA biology and genetic engineering techniques. Notable papers include:

  • "Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs," 2022, Nature Biotechnology
  • "Insulin-regulated serine and lipid metabolism drive peripheral neuropathy," 2023, Nature
  • "RNA editing: Expanding the potential of RNA therapeutics," 2023, Molecular Therapy
  • "Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice," 2021, Science Translational Medicine
  • "Scalable Functional Assays for the Interpretation of Human Genetic Variation," 2022, Annual Review of Genetics

Mali frequently collaborates with several co-authors. Researchers they have worked with on multiple projects include Kyle Ford, Amir Dailamy, Joseph Rainaldi, Trey Ideker, and J. Silvio Gutkind.

Their work has appeared predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Molecular Therapy, Blood, and Clinical Cancer Research. Among these, bioRxiv features the highest number of their publications.

Best Publications

  • RNA-Guided Human Genome Engineering via Cas9

    Prashant Mali;Luhan Yang;Kevin M. Esvelt;John Aach

  • CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering.

    Prashant Mali;John Aach;P Benjamin Stranges;Kevin M Esvelt

  • Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

    James E. DiCarlo;Julie E. Norville;Prashant Mali;Xavier Rios

  • Cas9 as a versatile tool for engineering biology

    Prashant Mali;Kevin M Esvelt;George M Church;George M Church

  • Highly multiplexed subcellular RNA sequencing in situ.

    Je Hyuk Lee;Evan R. Daugharthy;Jonathan Scheiman;Reza Kalhor

  • Orthogonal cas9 proteins for rna-guided gene regulation and editing

    George M. Church;Kevin M. Esvelt;Prashant G. Mali

  • Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

    Jizhong Zou;Morgan L. Maeder;Prashant Mali;Shondra M. Pruett-Miller

  • A multifunctional AAV-CRISPR-Cas9 and its host response

    Wei Leong Chew;Mohammadsharif Tabebordbar;Jason K W Cheng;Prashant Mali

  • Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

    Prashant Mali;Bin Kuan Chou;Jonathan Yen;Zhaohui Ye

  • Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

    Bin Kuan Chou;Prashant Mali;Xiaosong Huang;Zhaohui Ye

  • Optimization of scarless human stem cell genome editing

    Luhan Yang;Marc Guell;Susan Byrne;Joyce L. Yang

  • Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders

    Zhaohui Ye;Huichun Zhan;Prashant Mali;Prashant Mali;Sarah Dowey

  • Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach

    Raj Chari;Prashant Mali;Mark Moosburner;George M Church;George M Church

  • Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

    Andrzej Swistowski;Jun Peng;Qiuyue Liu;Prashant Mali

  • Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

    Jizhong Zou;Prashant Mali;Xiaosong Huang;Sarah N. Dowey

  • Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts

    Prashant Mali;Prashant Mali;Zhaohui Ye;Zhaohui Ye;Holly H. Hommond;Xiaobing Yu

  • Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions

    John Paul Shen;Dongxin Zhao;Roman Sasik;Jens Luebeck

  • Developmental barcoding of whole mouse via homing CRISPR

    Reza Kalhor;Reza Kalhor;Kian Kalhor;Leo Mejia;Kathleen Leeper

  • Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers

    Adrian Briggs;Xavier Rios;Rajagopal Chari;Luhan Yang

  • Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix

    Sharon Gerecht;Sravanti Kusuma

Frequent Co-Authors

George M. Church
George M. Church Harvard University
Linzhao Cheng
Linzhao Cheng Chinese Academy of Sciences
Zhaohui Ye
Zhaohui Ye US Food and Drug Administration
Trey Ideker
Trey Ideker University of California, San Diego
Kun Zhang
Kun Zhang University of California, San Diego
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Peter C. Searson
Peter C. Searson Johns Hopkins University
Mansun Law
Mansun Law Scripps Research Institute
Kang Zhang
Kang Zhang Macau University of Science and Technology

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