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Molecular Biology

D-Index
75
Citations
27867
World Ranking
1174
National Ranking
607

Overview

John Groffen is affiliated with the Children's Hospital of Los Angeles in the United States. Their research primarily focuses on the fields of immunology and microbiology, with notable contributions in subfields such as immunology, molecular biology, and public health, environmental and occupational health.

The scientist's work encompasses key topics including:

  • Galectins and Cancer Biology
  • Toxin Mechanisms and Immunotoxins
  • Glycosylation and Glycoproteins Research
  • Acute Lymphoblastic Leukemia research

John Groffen has published research articles in journals such as:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers include:

  • Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia, 2022, Journal of Medicinal Chemistry
  • Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with John Groffen are:

  • Fei Fei
  • Nora Heisterkamp
  • Khuchtumur Bum-Erdene
  • P.M. Collins
  • Matthew W. Hugo

Their research addresses critical aspects of leukemia and immunological mechanisms, exploring the roles of galectins in cancer biology and investigating the biochemical properties of toxins and immunotoxins. This work contributes to understanding disease pathways and potential therapeutic targets relevant to acute lymphoblastic leukemia and related fields.

Best Publications

  • Identification of FAP locus genes from chromosome 5q21

    Kenneth W. Kinzler;Mef C. Nilbert;Li Kuo Su;Bert Vogelstein

  • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

    Groffen J;Stephenson;Heisterkamp N;de Klein A

  • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

    Annelies de Klein;Ad Geurts van Kessel;Gerard Grosveld;Claus R. Bartram

  • Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction.

    Vesa Kaartinen;Jan Willem Voncken;Charles Shuler;David Warburton

  • Structural organization of the bcr gene and its role in the Ph' translocation.

    Heisterkamp N;Stam K;Groffen J;de Klein A

  • Localization of the c- abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

    Nora Heisterkamp;John R. Stephenson;John Groffen;Pamela F. Hansen

  • Translocation of c- abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

    Claus R. Bartram;Annelies de Klein;Anne Hagemeijer;Ton van Agthoven

  • Acute leukaemia in bcr/abl transgenic mice

    N Heisterkamp;G Jenster;J ten Hoeve;D Zovich

  • A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia.

    L C Chan;K K Karhi;S I Rayter;N Heisterkamp

  • Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

    U R Rapp;M D Goldsborough;G E Mark;T I Bonner

  • Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

    André Hermans;Nora Heisterkamp;Marieke von Lindern;Sjozef van Baal

  • TGFβ signaling plays a critical role in promoting alternative macrophage activation

    Dapeng Gong;Wei Shi;Sun-ju Yi;Hui Chen

  • Chromosomal localization of human cellular homologues of two viral oncogenes.

    Nora Heisterkamp;John Groffen;John R. Stephenson;N. K. Spurr

  • Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

    Jean-Paul Mira;Valerie Benard;John Groffen;Luraynne C. Sanders

  • Characterization of RAC3, a novel member of the Rho family

    Leena Haataja;John Groffen;Nora Heisterkamp

  • Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.

    K Stam;N Heisterkamp;G Grosveld;A de Klein

  • BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

    Jan Willem Voncken;Vesa Kaartinen;Paul K. Pattengale;Wilfred T.V. Germeraad

  • Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.

    S L Chissoe;A Bodenteich;Y F Wang;Y P Wang

  • Isolation and chromosomal localization of CRKL, a human crk-like gene.

    ten Hoeve J;Morris C;Heisterkamp N;Groffen J

  • TYROSINE PHOSPHORYLATION OF CRKL IN PHILADELPHIA+ LEUKEMIA

    J ten Hoeve;RB Arlinghaus;JQ Guo;N Heisterkamp

Frequent Co-Authors

Nora Heisterkamp
Nora Heisterkamp Children's Hospital of Los Angeles
Vesa Kaartinen
Vesa Kaartinen University of Michigan–Ann Arbor
Markus Müschen
Markus Müschen Yale University
John R. Stephenson
John R. Stephenson National Institutes of Health
Gerard Grosveld
Gerard Grosveld St. Jude Children's Research Hospital
Paul K. Pattengale
Paul K. Pattengale University of Southern California
Annelies de Klein
Annelies de Klein Erasmus University Rotterdam
David Warburton
David Warburton University of Southern California
Claus R. Bartram
Claus R. Bartram Heidelberg University

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