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Genetics

D-Index
55
Citations
14301
World Ranking
3562
National Ranking
125

Overview

Annelies de Klein is affiliated with Erasmus University Rotterdam in the Netherlands. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on ocular oncology and related fields.

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Subfields in which they have published extensively include Molecular Biology, Ophthalmology, Surgery, Pulmonary and Respiratory Medicine, and Genetics.

The scientist's research covers several topics, prominently including:

  • Ocular Oncology and Treatments
  • Retinal Development and Disorders
  • Congenital Diaphragmatic Hernia Studies
  • Renal and related cancers
  • Immunotherapy and Immune Responses
  • Esophageal and GI Pathology
  • Cutaneous Melanoma Detection and Management

Frequent publication venues for their work include:

  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Frontiers in Pediatrics
  • Investigative Ophthalmology & Visual Science

Among their recent publications are:

  • Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study (2020, Cancers)
  • Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing (2020, International Journal of Molecular Sciences)
  • Spliceosome Mutations in Uveal Melanoma (2020, International Journal of Molecular Sciences)
  • Molecular Genetics of Conjunctival Melanoma and Prognostic Value of TERT Promoter Mutation Analysis (2021, International Journal of Molecular Sciences)
  • Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus (2021, Clinical Epigenetics)

Collaborations have frequently involved colleagues such as Erwin Brosens, Emine Kılıç, Robert M. Verdijk, Nicole C. Naus, and Dion Paridaens. These coauthors have partnered with Annelies de Klein on multiple research projects, contributing to a body of work often centered on ocular and molecular biology topics.

Best Publications

  • Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

    Lars Guelen;Ludo Pagie;Emilie Brasset;Wouter Meuleman;Wouter Meuleman

  • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

    Annelies de Klein;Ad Geurts van Kessel;Gerard Grosveld;Claus R. Bartram

  • Localization of the c- abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

    Nora Heisterkamp;John R. Stephenson;John Groffen;Pamela F. Hansen

  • Translocation of c- abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

    Claus R. Bartram;Annelies de Klein;Anne Hagemeijer;Ton van Agthoven

  • Early-onset parkinsonism associated with PINK1 mutations Frequency, genotypes, and phenotypes

    V. Bonifati;C. F. Rohé;G. J. Breedveld;E. Fabrizio

  • Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.

    K Stam;N Heisterkamp;G Grosveld;A de Klein

  • Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases

    Serdar Yavuzyigitoglu;Anna E. Koopmans;Robert M. Verdijk;Jolanda Vaarwater

  • The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.

    Y Elgersma;L Kwast;A Klein;T Voorn-Brouwer

  • Uveal melanoma: Towards a molecular understanding.

    Kyra N. Smit;Martine J. Jager;Annelies de Klein;Emine Kiliҫ

  • Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma

    Anna E Koopmans;Robert M Verdijk;Rutger W W Brouwer;Thierry P P van den Bosch

  • Clinical and Cytogenetic Analyses in Uveal Melanoma

    Emine Kilic;Walter van Gils;Elisabeth Lodder;H. Berna Beverloo

  • Concurrent Loss of Chromosome Arm 1p and Chromosome 3 Predicts a Decreased Disease-Free Survival in Uveal Melanoma Patients

    Emine Kilic;Nicole C Naus;Walter van Gils;Caroline C Klaver

  • Variegated gene expression caused by cell-specific long-range DNA interactions

    Daan Noordermeer;Elzo de Wit;Petra Klous;Harmen van de Werken

  • Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association

    Pawaree Saisawat;Stefan Kohl;Alina C. Hilger;Alina C. Hilger;Daw Yang Hwang

  • Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder

    Przemyslaw Szafranski;Avinash V. Dharmadhikari;Erwin Brosens;Priyatansh Gurha;Priyatansh Gurha

  • Higher percentage of FISH-determined monosomy 3 and 8q amplification in uveal melanoma cells relate to poor patient prognosis.

    Thomas van den Bosch;Jackelien G M van Beek;Jolanda Vaarwater;Robert M Verdijk

  • Prognostic parameters in uveal melanoma and their association with BAP1 expression

    T Huibertus van Essen;Sake I van Pelt;Mieke Versluis;Inge H G Bronkhorst

  • Clinical geneticists' views of VACTERL/VATER association.

    Benjamin D. Solomon;Kelly A. Bear;Virginia Kimonis;Annelies de Klein

  • Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.

    Anne Hagemeijer;Annelies de Klein;Elisabeth Gödde-Salz;Claude Turc-Carel

  • Detection of genetic prognostic markers in uveal melanoma biopsies using fluorescence in situ hybridization.

    Nicole C. Naus;Anette C. A. Verhoeven;Ellen van Drunen;Rosalyn Slater

Frequent Co-Authors

Dick Tibboel
Dick Tibboel Erasmus University Rotterdam
Gerard Grosveld
Gerard Grosveld St. Jude Children's Research Hospital
Daryl A. Scott
Daryl A. Scott Baylor College of Medicine
Brendan Lee
Brendan Lee Baylor College of Medicine
H. Berna Beverloo
H. Berna Beverloo Erasmus University Rotterdam
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam
Ronald R. de Krijger
Ronald R. de Krijger Erasmus University Rotterdam
John R. Stephenson
John R. Stephenson National Institutes of Health
Claus R. Bartram
Claus R. Bartram Heidelberg University

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