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Wilfred F. J. van IJcken

Wilfred F. J. van IJcken

D-Index & Metrics

Genetics

D-Index
86
Citations
24421
World Ranking
1258
National Ranking
48

Overview

Wilfred F. J. van IJcken is affiliated with Erasmus MC in the Netherlands and has a broad research portfolio centered on biochemistry, genetics, molecular biology, and medicine.

Their work spans several key subfields including molecular biology, genetics, immunology, cancer research, and oncology. The main topics covered by their research include epigenetics and DNA methylation, genomics and chromatin dynamics, CRISPR and genetic engineering, cancer genomics and diagnostics, immune cell function and interaction, RNA research and splicing, and RNA modifications related to cancer.

Van IJcken has contributed to multiple recent papers, notable among them are:

  • Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling, 2020, Allergy
  • In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states, 2020, Nature Cell Biology
  • Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness, 2021, Nature Genetics
  • Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases, 2021, Science Immunology
  • Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcriptional control, 2020, Genome Research

Van IJcken frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, International Journal of Molecular Sciences, Scientific Reports, and Genes.

Their frequent collaborators include Rutger W. W. Brouwer, Joost Gribnau, Danny Huylebroeck, Ruben Boers, and Joachim Boers, with collaboration counts ranging from 22 to 39 joint publications.

Best Publications

  • Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

    Marjolein P. Baar;Renata M.C. Brandt;Diana A. Putavet;Julian D.D. Klein

  • Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.

    Sarah H Shahmoradian;Sarah H Shahmoradian;Amanda J Lewis;Christel Genoud;Jürgen Hench

  • Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.

    Jessica Zuin;Jesse R. Dixon;Michael I. J. A. van der Reijden;Zhen Ye;Zhen Ye

  • Gene expression-based classification of non-small cell lung carcinomas and survival prediction.

    Jun Hou;Joachim Aerts;Bianca den Hamer;Wilfred van IJcken

  • Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

    Víctor J. Carrión;Juan Perez-Jaramillo;Viviane Cordovez;Vittorio Tracanna

  • Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

    Joseph Borg;Petros Papadopoulos;Marianthi Georgitsi;Laura Gutiérrez

  • Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes

    Corine M. Beaufort;Jean C. A. Helmijr;Anna M. Piskorz;Marlous Hoogstraat

  • Exacerbated innate host response to SARS-CoV in aged non-human primates

    Saskia L. Smits;Anna de Lang;Judith M A van den Brand;Lonneke M Leijten

  • The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

    Erik Splinter;Elzo de Wit;Elphège P. Nora;Petra Klous

  • MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

    Hang Yin;Alessandra Pasut;Vahab D. Soleimani;C. Florian Bentzinger

  • Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

    Manfred Kayser;Fan Liu;A. Cecile J.W. Janssens;Fernando Rivadeneira

  • The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

    Eric Soler;Charlotte Andrieu-Soler;Ernie de Boer;Jan Christian Bryne

  • Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

    Erik Engelen;Umut Akinci;Jan Christian Bryne;Jun Hou

  • Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells.

    M. J. Crop;C. C. Baan;S. S. Korevaar;J. N. M. IJzermans

  • Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.

    Marije E.C. Meuwissen;Rachel Schot;Sofija Buta;Grétel Oudesluijs

  • Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

    James R Mitchell;Mariëlle Verweij;Karl Brand;Marieke van de Ven

  • The core spliceosome as target and effector of non-canonical ATM signalling

    Maria Tresini;Daniël O. Warmerdam;Petros Kolovos;Loes Snijder

  • MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

    Joris Pothof;Nicole S Verkaik;Wilfred van IJcken;Erik A C Wiemer

  • miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells.

    M T M van Jaarsveld;J Helleman;A W M Boersma;P F van Kuijk

  • Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

    Björn Schumacher;Ingrid van der Pluijm;Michael J. Moorhouse;Theodore Kosteas

Frequent Co-Authors

Frank Grosveld
Frank Grosveld Erasmus University Rotterdam
Boris Lenhard
Boris Lenhard Imperial College London
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam
Peter J. van der Spek
Peter J. van der Spek Erasmus University Rotterdam
Albert Hofman
Albert Hofman Harvard University
Sjaak Philipsen
Sjaak Philipsen Erasmus University Rotterdam
Albert D. M. E. Osterhaus
Albert D. M. E. Osterhaus University of Veterinary Medicine Hannover, Foundation
Rudi W. Hendriks
Rudi W. Hendriks Erasmus University Rotterdam

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