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Biology and Biochemistry

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74
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5701
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Overview

Wiltrud Richter is affiliated with the University Hospital Heidelberg in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields such as Rheumatology, Molecular Biology, Cell Biology, Surgery, and Genetics. The main topics addressed in their work include osteoarthritis treatment and mechanisms, proteoglycans and glycosaminoglycans research, cancer-related molecular mechanisms research, TGF-β signaling in diseases, fibroblast growth factor research, knee injuries and reconstruction techniques, and connective tissue disorders research.

Richter has contributed to numerous scientific publications, with notable recent papers including:

  • Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells (2020, Frontiers in Cell and Developmental Biology)
  • NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels (2022, Stem Cell Research & Therapy)
  • Sulfation of Glycosaminoglycan Hydrogels Instructs Cell Fate and Chondral versus Endochondral Lineage Decision of Skeletal Stem Cells In Vivo (2021, Advanced Functional Materials)
  • Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells (2020, Frontiers in Cell and Developmental Biology)
  • MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1 (2020, Stem Cell Research & Therapy)

Richter frequently publishes in venues such as:

  • Stem Cell Research & Therapy
  • Frontiers in Cell and Developmental Biology
  • Osteoarthritis and Cartilage
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells

Collaboration plays a role in Richter's work, with frequent co-authors including:

  • Solvig Diederichs
  • Matthias Gerstner
  • Safak Chasan
  • Simon I. Dreher
  • Tobias Renkawitz

The scope of Richter's research touches on various molecular and cellular mechanisms linked to skeletal and cartilage biology, with an emphasis on factors affecting differentiation and lineage decisions. This includes the study of molecular pathways such as WNT/β-Catenin signaling, NFκB inhibition, and the regulation of transcription factors like MEF2C and RUNX3.

Best Publications

  • Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice

    Karoliina Pelttari;Anja Winter;Eric Steck;Katrin Goetzke

  • Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.

    Anja Winter;Stephen Breit;Dominik Parsch;Karin Benz

  • Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFβ receptor and BMP profile and is overcome by BMP‐6

    Thea Hennig;Helga Lorenz;Angela Thiel;Katrin Goetzke

  • Porosity and pore size of beta-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study.

    Philip Kasten;Ingo Beyen;Philipp Niemeyer;Reto Luginbühl

  • Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects.

    Florian Geiger;Helge Bertram;Irina Berger;Helga Lorenz

  • Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma.

    Philipp Niemeyer;Katharina Fechner;Stefan Milz;Wiltrud Richter

  • The use of mesenchymal stem cells for chondrogenesis

    Karoliina Pelttari;Eric Steck;Wiltrud Richter

  • Induction of Intervertebral Disc–Like Cells From Adult Mesenchymal Stem Cells

    Eric Steck;Helge Bertram;Rainer Abel;Bohua Chen

  • Human articular chondrocytes secrete parathyroid hormone–related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis

    J. Fischer;A. Dickhut;M. Rickert;W. Richter

  • Autologous Chondrocyte Implantation Using the Original Periosteum-Cover Technique Versus Matrix-Associated Autologous Chondrocyte Implantation A Randomized Clinical Trial

    Felix Zeifang;Doris Oberle;Corinna Nierhoff;Wiltrud Richter

  • Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome.

    Klaus Dinkel;Hans-Michael Meinck;Karin M. Jury;Wolfram Karges

  • Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells

    S Weiss;T Hennig;R Bock;E Steck

  • New In Vivo Animal Model to Create Intervertebral Disc Degeneration and to Investigate the Effects of Therapeutic Strategies to Stimulate Disc Regeneration

    Markus W Kroeber;Frank Unglaub;Haili Wang;Carsten Schmid

  • Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics

    Julia P Vogel;Krisztian Szalay;Florian Geiger;Martin Kramer

  • Mesenchymal stem cells and cartilage in situ regeneration.

    W. Richter

  • Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

    John Kim;Wiltrud Richter;Henk Jan Aanstoot;Yuguang Shi

  • Osteoarthritis: cellular and molecular changes in degenerating cartilage.

    Helga Lorenz;Wiltrud Richter

  • VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute

    Florian Geiger;Helga Lorenz;W. Xu;Krisztian Szalay

  • Calcification or dedifferentiation: requirement to lock mesenchymal stem cells in a desired differentiation stage.

    Andrea Dickhut;Karoliina Pelttari;Patricia Janicki;Wolfgang Wagner

  • Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier.

    Philip Kasten;Julia Vogel;Reto Luginbühl;Philip Niemeyer

Frequent Co-Authors

Steinunn Baekkeskov
Steinunn Baekkeskov University of California, San Francisco
Yuguang Shi
Yuguang Shi The University of Texas Health Science Center at San Antonio
Hermann Ehrlich
Hermann Ehrlich TU Bergakademie Freiberg
Bernhard O. Boehm
Bernhard O. Boehm Nanyang Technological University
Hermann Brenner
Hermann Brenner German Cancer Research Center
Carsten Werner
Carsten Werner Leibniz-Institut für Polymerforschung Dresden e. V.
Til Stürmer
Til Stürmer University of North Carolina at Chapel Hill
Eike Brunner
Eike Brunner TU Dresden
Henning Madry
Henning Madry Saarland University
Judith V.M.G. Bovée
Judith V.M.G. Bovée Leiden University Medical Center

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