World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
79
Citations
28045
World Ranking
1629
National Ranking
57

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Wouter de Laat is affiliated with Utrecht University in the Netherlands, focusing on biochemistry, genetics, and molecular biology. Their research encompasses a variety of fields including molecular biology, plant science, immunology, pathology and forensic medicine, as well as ecology, evolution, behavior, and systematics.

The scientist's work primarily addresses topics such as genomics and chromatin dynamics, RNA research and splicing, epigenetics and DNA methylation, chromosomal and genetic variations, RNA and protein synthesis mechanisms, lymphoma diagnosis and treatment, and RNA modifications and cancer.

Several recent publications illustrate the scope of their research. These include:

  • "Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression," 2021, Molecular Cell
  • "Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart," 2020, Circulation Research
  • "Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing," 2021, Nature Communications
  • "Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies," 2020, Nature Protocols
  • "CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands," 2023, Nucleic Acids Research

Wouter de Laat frequently collaborates with several coauthors, including:

  • Peter H.L. Krijger (14 joint publications)
  • Marjon J.A.M. Verstegen (11 joint publications)
  • Amin Allahyar (6 joint publications)
  • Erik Splinter (6 joint publications)
  • Sjoerd J. D. Tjalsma (6 joint publications)

The scientist's research has been published in several prominent venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory) with 3 publications
  • Nucleic Acids Research with 2 publications
  • Cell Genomics with 2 publications
  • Blood with 2 publications
  • Molecular Cell with 1 publication

Wouter de Laat is recognized as a member of the European Molecular Biology Organization (EMBO), a distinction reflecting their contributions to the field. Their body of work spans a significant range of molecular biology topics, focusing especially on the mechanisms underlying chromatin dynamics, gene regulation via enhancers, and RNA processing.

Best Publications

  • Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

    Lars Guelen;Ludo Pagie;Emilie Brasset;Wouter Meuleman;Wouter Meuleman

  • Looping and interaction between hypersensitive sites in the active β-globin locus

    Bas Tolhuis;Robert Jan Palstra;Erik Splinter;Frank Grosveld

  • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

    Marieke Simonis;Petra Klous;Erik Splinter;Yuri Moshkin

  • CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

    Erik Splinter;Helen Heath;Jurgen Kooren;Robert-Jan Palstra

  • A decade of 3C technologies: insights into nuclear organization

    Elzo de Wit;Wouter de Laat

  • Quantitative analysis of chromosome conformation capture assays (3C-qPCR)

    Hélène Hagège;Petra Klous;Caroline Braem;Erik Splinter

  • A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Stefan Gröschel;Stefan Gröschel;Mathijs A Sanders;Remco Hoogenboezem;Elzo de Wit

  • The beta-globin nuclear compartment in development and erythroid differentiation.

    Robert-Jan Palstra;Bas Tolhuis;Erik Splinter;Rian Nijmeijer

  • Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

    Anneke M. Sijbers;Wouter L. De Laat;Rafael R. Ariza;Maureen Biggerstaff

  • CTCF Binding Polarity Determines Chromatin Looping

    Elzo de Wit;Erica S M Vos;Sjoerd J B Holwerda;Christian Valdes-Quezada

  • Topology of mammalian developmental enhancers and their regulatory landscapes

    Wouter de Laat;Denis Duboule;Denis Duboule

  • eRNAs are required for p53-dependent enhancer activity and gene transcription

    Carlos A. Melo;Carlos A. Melo;Jarno Drost;Patrick J. Wijchers;Harmen van de Werken

  • A Regulatory Archipelago Controls Hox Genes Transcription in Digits

    Thomas Montavon;Natalia Soshnikova;Bénédicte Mascrez;Elisabeth Joye

  • The active spatial organization of the β-globin locus requires the transcription factor EKLF

    Roy Drissen;Robert-Jan Palstra;Nynke Gillemans;Erik Splinter

  • Spatial organization of gene expression: the active chromatin hub.

    Wouter de Laat;Frank Grosveld

  • DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair

    Wouter L. de Laat;Esther Appeldoorn;Kaoru Sugasawa;Eric Weterings

  • The Dynamic Architecture of Hox Gene Clusters

    Daan Noordermeer;Marion Leleu;Erik Splinter;Jacques Rougemont;Jacques Rougemont

  • The second decade of 3C technologies: detailed insights into nuclear organization.

    Annette Denker;Wouter de Laat

  • Robust 4C-seq data analysis to screen for regulatory DNA interactions

    Harmen J G van de Werken;Gilad Landan;Sjoerd J B Holwerda;Sjoerd J B Holwerda;Michael Hoichman

  • CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

    Erik Splinter;Helen Heath;Jurgen Kooren;Robert-Jan Palstra

Frequent Co-Authors

Elzo de Wit
Elzo de Wit Antoni van Leeuwenhoek Hospital
Frank Grosveld
Frank Grosveld Erasmus University Rotterdam
Patrick T. Ellinor
Patrick T. Ellinor Harvard University
Denis Duboule
Denis Duboule Collège de France
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Bas van Steensel
Bas van Steensel Antoni van Leeuwenhoek Hospital
Vincent M. Christoffels
Vincent M. Christoffels University of Amsterdam
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Christopher Newton-Cheh
Christopher Newton-Cheh Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A strong foundation in genetics can open the door to a variety of rewarding careers in health sciences, research, and patient care. Many students interested in genetics also explore related healthcare fields, where online education options provide flexible and affordable entry points.

Future nurses and healthcare practitioners might consider affordable np programs for those aiming to become nurse practitioners, a vital and rapidly growing role in healthcare. Additionally, online nursing degree programs make it possible to earn a respected credential without sacrificing work or family commitments.

For registered nurses seeking career advancement, pursuing advanced practice degrees through msn to dnp programs can lead to leadership positions and specialized clinical expertise. Meanwhile, those looking for the most cost-effective option to advance can explore the cheapest rn to bsn online pathways.

With a growing number of accredited online programs, students interested in genetics, nursing, or advanced practice roles have more flexibility and opportunity than ever to craft a personalized and meaningful career journey.

Best Scientists Citing Wouter de Laat

Trending Scientists

Recently Published Articles