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Genetics

D-Index
56
Citations
17053
World Ranking
3464
National Ranking
121

Overview

Elzo de Wit is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands, contributing to the field of biochemistry, genetics, and molecular biology through extensive research activities.

Their work primarily focuses on molecular biology, where they have published 96 articles. Other subfields they have contributed to include plant science, immunology, oncology, and cancer research.

Key research topics addressed by de Wit include:

  • Genomics and Chromatin Dynamics
  • Chromosomal and Genetic Variations
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Plant Molecular Biology Research
  • RNA and protein synthesis mechanisms
  • Nuclear Structure and Function

De Wit has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), with 17 publications, as well as in Science, Nature Communications, Nature Structural & Molecular Biology, and EMBO Reports.

Some of the recent papers published by Elzo de Wit include:

  • "The structural basis for cohesin-CTCF-anchored loops," 2020, Nature
  • "3D genomics across the tree of life reveals condensin II as a determinant of architecture type," 2021, Science
  • "Hi-C analyses with GENOVA: a case study with cohesin variants," 2021, NAR Genomics and Bioinformatics
  • "WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation," 2020, Nature Genetics
  • "Macrophage-mediated myelin recycling fuels brain cancer malignancy," 2024, Cell

Throughout their career, de Wit has collaborated extensively with several coauthors, including Hans Teunissen, Bas van Steensel, Tom van Schaik, Ning Qing Liu, and Teun van den Brand.

Best Publications

  • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

    Marieke Simonis;Petra Klous;Erik Splinter;Yuri Moshkin

  • A decade of 3C technologies: insights into nuclear organization

    Elzo de Wit;Wouter de Laat

  • In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

    Anoek Zomer;Carrie Maynard;Frederik Johannes Verweij;Alwin Kamermans

  • The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

    Judith H.I. Haarhuis;Robin H. van der Weide;Vincent A. Blomen;J. Omar Yáñez-Cuna

  • A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Stefan Gröschel;Stefan Gröschel;Mathijs A Sanders;Remco Hoogenboezem;Elzo de Wit

  • CTCF Binding Polarity Determines Chromatin Looping

    Elzo de Wit;Erica S M Vos;Sjoerd J B Holwerda;Christian Valdes-Quezada

  • Characterization of the Drosophila melanogaster genome at the nuclear lamina

    Helen Pickersgill;Bernike Kalverda;Elzo de Wit;Wendy Talhout

  • eRNAs are required for p53-dependent enhancer activity and gene transcription

    Carlos A. Melo;Carlos A. Melo;Jarno Drost;Patrick J. Wijchers;Harmen van de Werken

  • Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster.

    Bas Tolhuis;Inhua Muijrers;Elzo de Wit;Hans Teunissen

  • Prospero Acts as a Binary Switch between Self-Renewal and Differentiation in Drosophila Neural Stem Cells

    Semil P. Choksi;Tony D. Southall;Torsten Bossing;Karin Edoff

  • Robust 4C-seq data analysis to screen for regulatory DNA interactions

    Harmen J G van de Werken;Gilad Landan;Sjoerd J B Holwerda;Sjoerd J B Holwerda;Michael Hoichman

  • The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

    Erik Splinter;Elzo de Wit;Elphège P. Nora;Petra Klous

  • The structural basis for cohesin–CTCF-anchored loops

    Yan Li;Judith H. I. Haarhuis;Ángela Sedeño Cacciatore;Roel Oldenkamp

  • Limitations and possibilities of small RNA digital gene expression profiling.

    Sam E V Linsen;Elzo de Wit;Georges Janssens;Sheila Heater

  • Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

    Evelyne Beerling;Daniëlle Seinstra;Elzo de Wit;Elzo de Wit;Lennart Kester

  • The pluripotent genome in three dimensions is shaped around pluripotency factors

    Elzo de Wit;Britta A. M. Bouwman;Yun Zhu;Petra Klous

  • Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

    Paula J P de Vree;Elzo de Wit;Mehmet Yilmaz;Monique van de Heijning

  • 4C technology: protocols and data analysis.

    Harmen J G van de Werken;Paula J P de Vree;Erik Splinter;Sjoerd J B Holwerda

  • Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

    Erik Splinter;Elzo de Wit;Harmen J.G. van de Werken;Petra Klous

  • Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster.

    Celine Moorman;Ling V. Sun;Junbai Wang;Elzo de Wit

Frequent Co-Authors

Wouter de Laat
Wouter de Laat Utrecht University
Bas van Steensel
Bas van Steensel Antoni van Leeuwenhoek Hospital
Harmen J. Bussemaker
Harmen J. Bussemaker Columbia University
Reuven Agami
Reuven Agami Antoni van Leeuwenhoek Hospital
Patrick T. Ellinor
Patrick T. Ellinor Harvard University
René H. Medema
René H. Medema Princess Máxima Center
Ran Elkon
Ran Elkon Tel Aviv University
Edwin Cuppen
Edwin Cuppen Utrecht University
Christopher Newton-Cheh
Christopher Newton-Cheh Harvard University

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