World's Best Scientists 2026 revealed!
William Stafford Noble

William Stafford Noble

D-Index & Metrics

Computer Science

D-Index
104
Citations
92216
World Ranking
293
National Ranking
161

Biology and Biochemistry

D-Index
112
Citations
91077
World Ranking
877
National Ranking
548

Research.com Recognitions

  • 2001 - Fellow of Alfred P. Sloan Foundation

Overview

William Stafford Noble is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant work also in Chemistry. Subfields of study include Molecular Biology, Spectroscopy, Biophysics, Genetics, and Plant Science.

The scientist's main research topics focus on advanced techniques and applications in proteomics and mass spectrometry, as well as genomic and chromatin dynamics. Additional topics include single-cell and spatial transcriptomics, metabolomics and mass spectrometry studies, RNA research and splicing, and genomics and phylogenetic studies.

William Stafford Noble has published extensively, with frequent coauthors including Uri Keich, William E. Fondrie, Jacob Schreiber, Jay Shendure, and Michael J. MacCoss. Their work appears regularly in several prominent publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Proteome Research
  • Nature Communications
  • Bioinformatics
  • Genome biology

Notable recent papers authored or coauthored by Noble include:

  • "Navigating the pitfalls of applying machine learning in genomics" (2021, Nature Reviews Genetics)
  • "Systematic reconstruction of cellular trajectories across mouse embryogenesis" (2022, Nature Genetics)
  • "A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning" (2020, Molecular Cell)
  • "A single-cell time-lapse of mouse prenatal development from gastrula to birth" (2024, Nature)
  • "Avocado: a multi-scale deep tensor factorization method learns a latent representation of the human epigenome" (2020, Genome biology)

William Stafford Noble was awarded the Fellow of Alfred P. Sloan Foundation in 2001.

Best Publications

  • MEME Suite: tools for motif discovery and searching

    Timothy L. Bailey;Mikael Bodén;Fabian A. Buske;Martin C. Frith

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • The MEME Suite

    Timothy L. Bailey;James Johnson;Charles E. Grant;William S. Noble

  • FIMO: scanning for occurrences of a given motif.

    Charles E. Grant;Timothy L. Bailey;William Stafford Noble

  • What is a support vector machine

    William S Noble

  • The ENCODE (ENCyclopedia of DNA elements) Project

    E. A. Feingold;P. J. Good;M. S. Guyer;S. Kamholz

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • Semi-supervised learning for peptide identification from shotgun proteomics datasets

    Lukas Käll;Jesse D Canterbury;Jason Weston;William Stafford Noble

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Jill E. Moore;Michael J. Purcaro;Henry E. Pratt;Charles B. Epstein

  • Quantifying similarity between motifs

    Shobhit Gupta;John A Stamatoyannopoulos;Timothy L Bailey;William Stafford Noble

  • Machine learning applications in genetics and genomics

    Maxwell W. Libbrecht;William Stafford Noble

  • Assessing computational tools for the discovery of transcription factor binding sites.

    Martin Tompa;Nan Li;Timothy L. Bailey;George M. Church

  • A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

    Richard M. Myers;John Stamatoyannopoulos;Michael Snyder;Ian Dunham

  • The spectrum kernel: a string kernel for SVM protein classification.

    Christina S. Leslie;Eleazar Eskin;William Stafford Noble

  • A three-dimensional model of the yeast genome

    Zhijun Duan;Mirela Andronescu;Kevin Schutz;Sean McIlwain

  • Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.

    Jie Wang;Jiali Zhuang;Sowmya Iyer;Sowmya Iyer;XinYing Lin

  • Mismatch string kernels for discriminative protein classification

    Christina S. Leslie;Eleazar Eskin;Adiel Cohen;Jason Weston

  • How does multiple testing correction work

    William Stafford Noble

  • A statistical framework for genomic data fusion

    Gert R. G. Lanckriet;Tijl De Bie;Nello Cristianini;Michael I. Jordan

  • Integrative annotation of chromatin elements from ENCODE data

    Michael M. Hoffman;Jason Ernst;Jason Ernst;Jason Ernst;Steven P. Wilder;Anshul Kundaje;Anshul Kundaje

  • A three-dimensional model of the yeast genome

    William Noble;Zhi-un Duan;Mirela Andronescu;Kevin Schutz

  • The spectrum kernel

    Christina Leslie;Eleazar Eskin;William Stafford Noble

Frequent Co-Authors

Jeff A. Bilmes
Jeff A. Bilmes University of Washington
Jay Shendure
Jay Shendure University of Washington
Ferhat Ay
Ferhat Ay La Jolla Institute For Allergy & Immunology
Jean-Philippe Vert
Jean-Philippe Vert Google (United States)
Michael J. MacCoss
Michael J. MacCoss University of Washington
Christina S. Leslie
Christina S. Leslie Memorial Sloan Kettering Cancer Center
Christine M. Disteche
Christine M. Disteche University of Washington
Jason Weston
Jason Weston Facebook (United States)
John A. Stamatoyannopoulos
John A. Stamatoyannopoulos University of Washington
Job Dekker
Job Dekker University of Massachusetts Chan Medical School

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