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Biology and Biochemistry

D-Index
71
Citations
19089
World Ranking
6602
National Ranking
3074

Overview

Mark L. Kahn is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on medicine, with a strong emphasis on neurology, molecular biology, oncology, pulmonary and respiratory medicine, and infectious diseases.

The scientist's work centers on several main topics, including vascular malformations diagnosis and treatment, intracranial aneurysms treatment and complications, intracerebral and subarachnoid hemorrhage research, lymphatic system and diseases, pregnancy and preeclampsia studies, COVID-19 clinical research studies, and the long-term effects of COVID-19.

Recent publications by Mark L. Kahn highlight various areas within these fields. Notable papers include:

  • PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism, 2021, Nature
  • Cerebral Cavernous Malformation: From Mechanism to Therapy, 2021, Circulation Research
  • Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow, 2020, Journal of Clinical Investigation
  • Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment, 2020, Communications Biology
  • Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction, 2021, Journal of Clinical Investigation

Mark L. Kahn collaborates frequently with a group of researchers including Jisheng Yang, Alan T. Tang, Romuald Girard, Issam A. Awad, and Douglas A. Marchuk. These coauthors have contributed substantially to the breadth of Kahn's research output.

The scientist has published extensively in several prominent venues. These include bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Investigation, Nature Cardiovascular Research, Blood, and Stroke.

Best Publications

  • A dual thrombin receptor system for platelet activation

    Mark L. Kahn;Yao-Wu Zheng;Wei Huang;Violeta Bigornia

  • Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

    Mark L. Kahn;Mayumi Nakanishi-Matsui;Michael J. Shapiro;Hiroaki Ishihara

  • Protease-activated receptor 3 is a second thrombin receptor in humans.

    Hiroaki Ishihara;Andrew J. Connolly;Dewan Zeng;Mark L. Kahn

  • Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice

    R. J. Lucas;S. Hattar;M. Takao;D. M. Berson

  • Role of the thrombin receptor in development and evidence for a second receptor

    Andrew J. Connolly;Hiroaki Ishihara;Mark L. Kahn;Robert V. Farese

  • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

    Stephan K. Böhm;Wuyi Kong;Dieter Brömme;Steven P. Smeekens

  • Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

    Farhad Abtahian;Anastasia Guerriero;Eric Sebzda;Min-Min Lu

  • Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling

    Cara C. Bertozzi;Alec A. Schmaier;Patricia Mericko;Paul R. Hess

  • Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

    Brett H. Herzog;Jianxin Fu;Jianxin Fu;Stephen J. Wilson;Paul R. Hess

  • Klf2 Is an Essential Regulator of Vascular Hemodynamic Forces In Vivo

    John S. Lee;Qing Yu;Jordan T. Shin;Eric Sebzda

  • Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice

    Jonathan R. Lindner;Mark L. Kahn;Shaun R. Coughlin;Gilberto R. Sambrano

  • Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

    Sophie E. Acton;Jillian L. Astarita;Deepali Malhotra;Veronika Lukacs-Kornek

  • Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

    Zinan Zhou;Alan T. Tang;Weng Yew Wong;Sharika Bamezai

  • Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

    Alan T. Tang;Jaesung P. Choi;Jonathan J. Kotzin;Yiqing Yang

  • Protease activated receptors: theme and variations.

    Peter J O'Brien;Marina Molino;Mark Kahn;Lawrence F Brass

  • Platelet ITAM signaling is critical for vascular integrity in inflammation

    Yacine Boulaftali;Paul R. Hess;Todd M. Getz;Agnieszka Cholka

  • Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns

    Eric Sebzda;Eric Sebzda;Zhiying Zou;John S Lee;Tao Wang

  • Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

    Benjamin Kleaveland;Xiangjian Zheng;Jian J Liu;Yannick Blum

  • Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells.

    Eric Camerer;Hiroshi Kataoka;Mark Kahn;Katy Lease

  • GPVI and α2β1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow

    Kendra L. Sarratt;Hong Chen;Hong Chen;Mary M. Zutter;Mary M. Zutter;Samuel A. Santoro;Samuel A. Santoro

Frequent Co-Authors

Issam A. Awad
Issam A. Awad University of Chicago
Shaun R. Coughlin
Shaun R. Coughlin University of California, San Francisco
Douglas A. Marchuk
Douglas A. Marchuk Duke University
Mark H. Ginsberg
Mark H. Ginsberg University of California, San Diego
Michael C. Berndt
Michael C. Berndt Curtin University
Gary A. Koretzky
Gary A. Koretzky Cornell University
Lawrence F. Brass
Lawrence F. Brass University of Pennsylvania
Elizabeth E. Gardiner
Elizabeth E. Gardiner Australian National University
Wojciech Swat
Wojciech Swat Washington University in St. Louis
Guillermo Oliver
Guillermo Oliver Northwestern University

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