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Biology and Biochemistry

D-Index
49
Citations
13979
World Ranking
17855
National Ranking
7307

Overview

Orion D. Weiner is affiliated with the University of California, San Francisco in the United States. Their research falls primarily within the broad field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cell Biology, and Immunology, including the subfield of Cellular and Molecular Neuroscience.

The scientist's work covers several main topics, including:

  • Cellular Mechanics and Interactions
  • Cell Adhesion Molecules Research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Hippo pathway signaling and YAP/TAZ
  • Microtubule and mitosis dynamics
  • RNA and protein synthesis mechanisms
  • Cellular transport and secretion

Among their recent publications are the following papers:

  • "Cell protrusions and contractions generate long-range membrane tension propagation" (2023), published in Cell
  • "Molecular mechanism of GPCR spatial organization at the plasma membrane" (2023), published in Nature Chemical Biology
  • "Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation" (2022), published in eLife
  • "The WAVE complex associates with sites of saddle membrane curvature" (2021), published in The Journal of Cell Biology
  • "WASP integrates substrate topology and cell polarity to guide neutrophil migration" (2021), published in The Journal of Cell Biology

Orion D. Weiner collaborates frequently with several co-authors, including:

  • Jason P. Town
  • Kirstin Meyer
  • Henry De Belly
  • Hervé Turlier
  • Shannon Yan

The scientist has published primarily in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Zenodo (CERN European Organization for Nuclear Research)
  • The Journal of Cell Biology
  • eLife

Best Publications

  • Spatiotemporal control of cell signalling using a light-switchable protein interaction

    Anselm Levskaya;Orion D. Weiner;Orion D. Weiner;Wendell A. Lim;Christopher A. Voigt

  • Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

    Guy Servant;Orion D. Weiner;Paul Herzmark;Tamás Balla

  • Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration

    Andrew R. Houk;Alexandra Jilkine;Cecile O. Mejean;Rostislav Boltyanskiy

  • A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.

    Orion D. Weiner;Paul O. Neilsen;Glenn D. Prestwich;Marc W. Kirschner

  • Use the force: membrane tension as an organizer of cell shape and motility.

    Alba Diz-Muñoz;Daniel A. Fletcher;Daniel A. Fletcher;Orion D. Weiner

  • Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils.

    Fei Wang;Paul Herzmark;Orion D. Weiner;Supriya Srinivasan

  • Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

    Jared E. Toettcher;Orion D. Weiner;Wendell A. Lim

  • An actin-based wave generator organizes cell motility

    Orion D Weiner;William A Marganski;Lani F Wu;Steven J Altschuler

  • Illuminating cell signalling with optogenetic tools

    Doug Tischer;Orion D. Weiner

  • An optogenetic gene expression system with rapid activation and deactivation kinetics

    Laura B Motta-Mena;Anna Reade;Michael J Mallory;Spencer Glantz

  • Leukocytes navigate by compass: roles of PI3Kγ and its lipid products

    Paula Rickert;Orion D. Weiner;Fei Wang;Henry R. Bourne

  • Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains

    Manojkumar A. Puthenveedu;Benjamin Lauffer;Paul Temkin;Rachel Vistein

  • Spatial control of actin polymerization during neutrophil chemotaxis.

    Orion D. Weiner;Guy Servant;Matthew D. Welch;Matthew D. Welch;Timothy J. Mitchison;Timothy J. Mitchison

  • Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

    Orion D Weiner

  • Light-based feedback for controlling intracellular signaling dynamics

    Jared E Toettcher;Delquin Gong;Wendell A Lim;Orion D Weiner

  • Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis.

    Guy Servant;Orion D. Weiner;Enid R. Neptune;John W. Sedat

  • The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

    Jared E Toettcher;Christopher A Voigt;Orion D Weiner;Wendell A Lim

  • Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity.

    Jeffrey M Alexander;Juan Guan;Bingkun Li;Lenka Maliskova

  • Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals.

    Daniel Kalman;Orion D. Weiner;Danika L. Goosney;John W. Sedat

  • PIP3, PIP2, and Cell Movement—Similar Messages, Different Meanings?

    Robert H. Insall;Orion D. Weiner

Frequent Co-Authors

Wendell A. Lim
Wendell A. Lim University of California, San Francisco
Henry R. Bourne
Henry R. Bourne University of California, San Francisco
Michael Glogauer
Michael Glogauer University of Toronto
John W. Sedat
John W. Sedat University of California, San Francisco
Marc W. Kirschner
Marc W. Kirschner Harvard University
Didier Y. R. Stainier
Didier Y. R. Stainier Max Planck Society
Paul A. Slesinger
Paul A. Slesinger Icahn School of Medicine at Mount Sinai
Dianqing Wu
Dianqing Wu Yale University
Kevin H. Gardner
Kevin H. Gardner City University of New York

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