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Molecular Biology

D-Index
102
Citations
55190
World Ranking
487
National Ranking
272

Overview

Wendell A. Lim is affiliated with the University of California, San Francisco in the United States. Their research spans multiple fields including Medicine, Engineering, and Immunology and Microbiology, with significant contributions in Oncology, Biomedical Engineering, Immunology, Molecular Biology, and Electrical and Electronic Engineering.

The scientist's main research topics center on CAR-T cell therapy, with additional work focused on nanowire synthesis and applications, immunotherapy and immune responses, T-cell and B-cell immunology, immune cell function and interaction, nanofabrication and lithography techniques, and 3D printing in biomedical research.

Publications by Wendell A. Lim frequently appear in prominent venues such as:

  • Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Regular and Young Investigator Award Abstracts
  • Cell

Recent scholarly contributions include:

  • SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma, 2021, Science Translational Medicine
  • Synthetic cytokine circuits that drive T cells into immune-excluded tumors, 2022, Science
  • T cell circuits that sense antigen density with an ultrasensitive threshold, 2021, Science
  • Engineering synthetic morphogen systems that can program multicellular patterning, 2020, Science
  • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression, 2021, Cell

Wendell A. Lim has collaborated extensively with several researchers, including Milos Simic, Wei Yu, Hideho Okada, Payal Watchmaker, and Lia Cardarelli. These frequent coauthors reflect ongoing collaborative efforts across their research fields.

Best Publications

  • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

    Lei S. Qi;Matthew H. Larson;Luke A. Gilbert;Jennifer A. Doudna

  • CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

    Luke A. Gilbert;Matthew H. Larson;Leonardo Morsut;Zairan Liu

  • Deciphering the message in protein sequences: tolerance to amino acid substitutions

    James U. Bowie;John F. Reidhaar-Olson;Wendell A. Lim;Robert T. Sauer

  • CRISPR interference (CRISPRi) for sequence-specific control of gene expression

    Matthew H Larson;Luke A Gilbert;Luke A Gilbert;Xiaowo Wang;Wendell A Lim

  • The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

    Nicole King;M Jody Westbrook;Susan L Young;Alan Kuo

  • Mechanism and role of PDZ domains in signaling complex assembly.

    Baruch Z. Harris;Wendell A. Lim

  • Spatiotemporal control of cell signalling using a light-switchable protein interaction

    Anselm Levskaya;Orion D. Weiner;Orion D. Weiner;Wendell A. Lim;Christopher A. Voigt

  • The Principles of Engineering Immune Cells to Treat Cancer

    Wendell A. Lim;Carl H. June

  • Defining Network Topologies that Can Achieve Biochemical Adaptation

    Wenzhe Ma;Ala Trusina;Ala Trusina;Hana El-Samad;Hana El-Samad;Wendell A. Lim;Wendell A. Lim

  • Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

    Jesse G. Zalatan;Michael E. Lee;Ricardo Almeida;Luke A. Gilbert;Luke A. Gilbert

  • Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

    Matthew C. Good;Jesse G. Zalatan;Wendell A. Lim

  • Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

    Antonia A. Dominguez;Wendell A. Lim;Lei S. Qi

  • Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.

    Kole T. Roybal;Kole T. Roybal;Levi J. Rupp;Levi J. Rupp;Leonardo Morsut;Leonardo Morsut;Whitney J. Walker;Whitney J. Walker

  • Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.

    Leonardo Morsut;Kole T. Roybal;Kole T. Roybal;Xin Xiong;Xin Xiong;Russell M. Gordley;Russell M. Gordley

  • PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.

    Karen S. Christopherson;Brian J. Hillier;Wendell A. Lim;David S. Bredt

  • Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

    Chia Yung Wu;Kole T. Roybal;Elias M. Puchner;James Onuffer

  • Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.

    Wendell A. Lim;Frederic M. Richards;Robert O. Fox;Robert O. Fox

  • Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

    Brian J. Hillier;Karen S. Christopherson;Kenneth E. Prehoda;David S. Bredt

  • CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.

    Levi J. Rupp;Kathrin Schumann;Kole T. Roybal;Rachel E. Gate

  • Defining network topologies that can achieve biochemical adaptation

    Chao Tang;Wenzhe Ma;Ala Trusina;Hana El-Samad

Frequent Co-Authors

Lei S. Qi
Lei S. Qi Stanford University
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Martin Jinek
Martin Jinek University of Zurich
Orion D. Weiner
Orion D. Weiner University of California, San Francisco
Emmanuelle Charpentier
Emmanuelle Charpentier Max Planck Institute for Infection Biology
Tony Pawson
Tony Pawson University of Toronto
Pedro Beltrao
Pedro Beltrao European Bioinformatics Institute
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Luke A. Gilbert
Luke A. Gilbert University of California, San Francisco

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