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Robert T. Sauer

Robert T. Sauer

D-Index & Metrics

Molecular Biology

D-Index
126
Citations
56523
World Ranking
215
National Ranking
130

Biology and Biochemistry

D-Index
127
Citations
56955
World Ranking
473
National Ranking
304

Research.com Recognitions

  • 1996 - Member of the National Academy of Sciences
  • 1993 - Fellow of the American Academy of Arts and Sciences

Overview

Robert T. Sauer is affiliated with MIT in the United States and has a research focus within the broad field of Biochemistry, Genetics and Molecular Biology. Their work primarily concentrates on Molecular Biology, Genetics, and Cell Biology, with additional interest in Ecology and Materials Chemistry.

The scientist's primary research topics include:

  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • Cellular transport and secretion
  • Bacteriophages and microbial interactions
  • Signaling Pathways in Disease
  • Enzyme Structure and Function
  • Endoplasmic Reticulum Stress and Disease

Recent publications reflect an emphasis on protein machinery and proteolytic processes. Notable papers include:

  • "Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate" (2020, eLife)
  • "Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates" (2020, eLife)
  • "Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis" (2021, Critical Reviews in Biochemistry and Molecular Biology)
  • "The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation" (2020, Cell Reports)
  • "ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa" (2020, Molecular Microbiology)

Frequent co-authors associated with Robert T. Sauer include:

  • Tania A. Baker
  • Alireza Ghanbarpour
  • Joseph H. Davis
  • Tristan A. Bell
  • Fei X

Common publication venues for their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Cell Reports
  • Proceedings of the National Academy of Sciences
  • Protein Science

Robert T. Sauer has been recognized with membership in the National Academy of Sciences since 1996 and is a Fellow of the American Academy of Arts and Sciences since 1993.

Best Publications

  • Deciphering the message in protein sequences: tolerance to amino acid substitutions

    James U. Bowie;John F. Reidhaar-Olson;Wendell A. Lim;Robert T. Sauer

  • Protein-DNA Recognition

    Carl O. Pabo;Robert T. Sauer

  • Transcription factors: structural families and principles of DNA recognition

    Carl O. Pabo;Robert T. Sauer

  • Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

    Kenneth C. Keiler;Patrick R. H. Waller;Robert T. Sauer

  • The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

    Susan Gottesman;Eric Roche;YanNing Zhou;Robert T. Sauer

  • AAA+ proteases: ATP-fueled machines of protein destruction.

    Robert T. Sauer;Tania A. Baker

  • OMP Peptide Signals Initiate the Envelope-Stress Response by Activating DegS Protease via Relief of Inhibition Mediated by Its PDZ Domain

    Nathan P Walsh;Benjamin M Alba;Baundauna Bose;Carol A Gross

  • Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.

    Julia M Flynn;Saskia B Neher;Yong In Kim;Robert T Sauer

  • Genetic Analysis of Protein Stability and Function

    Andrew A. Pakula;Robert T. Sauer

  • Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences

    John F. Reidhaar-Olson;Robert T. Sauer

  • How the λ repressor and cro work

    M. Ptashne;A. Jeffrey;A.D. Johnson;R. Maurer

  • Homology among DNA-binding proteins suggests use of a conserved super-secondary structure.

    R. T. Sauer;R. R. Yocum;R. F. Doolittle;M. Lewis

  • Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.

    James C. Hu;Erin K. O'Shea;Peter S. Kim;Robert T. Sauer

  • The SsrA-SmpB system for protein tagging, directed degradation and ribosome rescue.

    Karzai Aw;Roche Ed;Sauer Rt

  • Alternative packing arrangements in the hydrophobic core of λrepresser

    Wendell A. Lim;Robert T. Sauer

  • lambda Repressor and cro--components of an efficient molecular switch.

    Alexander D. Johnson;Anthony R. Poteete;Anthony R. Poteete;Gail Lauer;Robert T. Sauer

  • ClpXP, an ATP-powered unfolding and protein-degradation machine

    Tania A. Baker;Robert T. Sauer

  • Sculpting the Proteome with AAA+ Proteases and Disassembly Machines

    Robert T. Sauer;Daniel N. Bolon;Briana M. Burton;Randall E. Burton

  • Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene Reduplication

    H. D. Niall;M. L. Hogan;R. Sauer;I. Y. Rosenblum

  • Optimizing the stability of single-chain proteins by linker length and composition mutagenesis

    Clifford R. Robinson;Robert T. Sauer

Frequent Co-Authors

James U. Bowie
James U. Bowie University of California, Los Angeles
Martin Karplus
Martin Karplus Harvard University
Andreas Martin
Andreas Martin University of California, Berkeley
Wendell A. Lim
Wendell A. Lim University of California, San Francisco
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
John T. Potts
John T. Potts Harvard University
Henry T. Keutmann
Henry T. Keutmann Harvard University
Stephen C. Harrison
Stephen C. Harrison Harvard University

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