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Biology and Biochemistry

D-Index
65
Citations
16307
World Ranking
9091
National Ranking
697

Research.com Recognitions

  • 2005 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Lynne Regan is affiliated with the University of Edinburgh in the United Kingdom and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Molecular Biology, Biophysics, and Structural Biology. Their research spans advanced microscopy techniques, protein structure, and biochemical characterization.

The scientist's recent publications demonstrate a focus on super-resolution microscopy techniques and protein interactions inside living cells. Notable papers include:

  • LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions, 2020, Communications Biology
  • PAINT using proteins: A new brush for super-resolution artists, 2020, Protein Science
  • Analyses of protein cores reveal fundamental differences between solution and crystal structures, 2020, Proteins Structure Function and Bioinformatics
  • Live-cell super-resolution imaging of actin using LifeAct -14 with a PAINT-based approach, 2022, Protein Science
  • Applications of cell free protein synthesis in protein design, 2024, Protein Science

Their collaborations include frequent co-authors such as Mathew H. Horrocks, Curran Oi, Zoe Gidden, Corey S. O'Hern, and Alex T. Grigas. These partnerships have contributed to a consistent output of research in various specialized topics.

Publications are often featured in scientific venues such as Protein Science, bioRxiv (Cold Spring Harbor Laboratory), arXiv (Cornell University), Biophysical Journal, and the University of Edinburgh's own publications.

Lynne Regan's research topics cover a broad array of advanced imaging and protein structure studies. Key areas include:

  • Advanced Fluorescence Microscopy Techniques
  • Advanced Electron Microscopy Techniques and Applications
  • Protein Structure and Dynamics
  • Cell Image Analysis Techniques
  • Enzyme Structure and Function
  • Biochemical and Structural Characterization
  • Monoclonal and Polyclonal Antibodies Research

In recognition of their academic contributions, Lynne Regan was awarded a fellowship from the John Simon Guggenheim Memorial Foundation in 2005.

Best Publications

  • TPR proteins: the versatile helix.

    Luca D. D'Andrea;Lynne Regan

  • Characterization of a helical protein designed from first principles

    Lynne Regan;William F. DeGrado

  • Antiparallel Leucine Zipper-Directed Protein Reassembly: Application to the Green Fluorescent Protein

    Indraneel Ghosh;and Andrew D. Hamilton;Lynne Regan

  • A Thermodynamic Scale for the .beta.-Sheet Forming Tendencies of the Amino Acids

    Catherine K. Smith;Jane M. Withka;Lynne Regan

  • Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.

    Thomas J. Magliery;Christopher G. M. Wilson;Weilan Pan;Dennis Mishler

  • Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Chrisostomos Prodromou;Giuliano Siligardi;Ronan O'Brien;Derek N. Woolfson

  • Structure and function of KH domains

    Roberto Valverde;Laura Edwards;Lynne Regan

  • Guidelines for Protein Design: The Energetics of β Sheet Side Chain Interactions

    Catherine K. Smith;Lynne Regan

  • Design of stable alpha-helical arrays from an idealized TPR motif.

    Ewan R.G. Main;Yong Xiong;Melanie J. Cocco;Luca D'Andrea

  • Protein–protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area

    Jieming Chen;Nicholas Sawyer;Lynne Regan

  • What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties

    Mary Munson;Suganthi Balasubramanian;Karen G. Fleming;Athena D. Nagi

  • An inverse correlation between loop length and stability in a four-helix-bundle protein

    Athena D. Nagi;Lynne Regan

  • A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro

    Marina Ramírez-Alvarado;Jane S. Merkel;Lynne Regan

  • Protein alchemy: Changing β-sheet into α-helix

    Seema Dalal;Suganthi Balasubramanian;Lynne Regan

  • A tetrahedral zinc(II)-binding site introduced into a designed protein.

    Lynne Regan;Neil D. Clarke

  • The interface of protein structure, protein biophysics, and molecular evolution.

    David A Liberles;Sarah A Teichmann;Ivet Bahar;Ugo Bastolla

  • THE DESIGN OF METAL-BINDING SITES IN PROTEINS

    Lynne Regan

  • Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase.

    Maria Jasin;Lynne Regan;Paul Schimmel

  • Protein design: novel metal-binding sites

    Lynne Regan

  • Redesigning the hydrophobic core of a four‐helix‐bundle protein

    Mary Munson;Lynne Regan;Ronan O'Brien;Julian M. Sturtevant

Frequent Co-Authors

Simon G. J. Mochrie
Simon G. J. Mochrie Yale University
Paul Schimmel
Paul Schimmel Scripps Research Institute
Chinedum O. Osuji
Chinedum O. Osuji University of Pennsylvania
Mark Gerstein
Mark Gerstein Yale University
Julian M. Sturtevant
Julian M. Sturtevant Yale University
Derek N. Woolfson
Derek N. Woolfson University of Bristol
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Yong Xiong
Yong Xiong Yale University
Axel T. Brunger
Axel T. Brunger Stanford University
William F. DeGrado
William F. DeGrado University of California, San Francisco

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