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Biology and Biochemistry

D-Index
56
Citations
13057
World Ranking
14305
National Ranking
6030

Overview

Christopher D. Link is affiliated with the University of Colorado Boulder in the United States. Their research spans multiple fields within the life sciences, with significant contributions particularly in medicine, biochemistry, genetics and molecular biology, and neuroscience.

Their work is concentrated in several specialized subfields, including molecular biology, neurology, physiology, biological psychiatry, and biomedical engineering. These areas provide a foundation for their investigations into complex biological processes and diseases.

Key research topics addressed by Christopher D. Link include:

  • Neuroinflammation and neurodegeneration mechanisms
  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Amyotrophic lateral sclerosis research
  • RNA regulation and disease
  • Gut microbiota and health
  • Immune response and inflammation

Their publication record includes articles in various scientific venues. Some of the frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain Behavior and Immunity
  • The Journal of Heart and Lung Transplantation
  • Innovation in Aging
  • GeroScience

Recent papers authored or coauthored by Christopher D. Link demonstrate engagement with topics centered on neurobiology and aging. Notable publications include:

  • "The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging" (2020, GeroScience)
  • "Is There a Brain Microbiome?" (2021, Neuroscience Insights)
  • "Amyloid beta acts synergistically as a pro-inflammatory cytokine" (2021, Neurobiology of Disease)
  • "The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction" (2023, Aging Cell)
  • "Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine" (2022, ACS Chemical Neuroscience)

Collaboration is a key aspect of their research activity. Frequent coauthors include:

  • Charles A. Hoeffer
  • Thomas J. LaRocca
  • Maddie R. Lemieux
  • Mark R. Opp
  • Alyssa N. Cavalier

Best Publications

  • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

    Christopher D. Link

  • Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity

    Yong Jie Zhang;Ya Fei Xu;Casey Cook;Tania F. Gendron

  • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

    S M Yatin;S Varadarajan;C D Link;D A Butterfield

  • Amyloid-β-Induced Pathological Behaviors Are Suppressed by Ginkgo biloba Extract EGb 761 and Ginkgolides in Transgenic Caenorhabditis elegans

    Yanjue Wu;Zhixin Wu;Peter Butko;Yves Christen

  • Oxidative stress precedes fibrillar deposition of Alzheimer’s disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model

    Jennifer Drake;Christopher D Link;D.Allan Butterfield

  • RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

    Briana Van Treeck;David S. W. Protter;Tyler Matheny;Anthony Khong

  • A global analysis of Caenorhabditis elegans operons

    Thomas Blumenthal;Donald Evans;Christopher D. Link;Alessandro Guffanti

  • Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

    Mercedes Prudencio;Veronique V Belzil;Ranjan Batra;Christian A Ross

  • Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model.

    Christopher D Link;Andrew Taft;Vadim Kapulkin;Kyle Duke

  • C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

    Yong Jie Zhang;Tania F. Gendron;Jonathan C. Grima;Hiroki Sasaguri

  • Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.

    Debraj GuhaThakurta;Lisanne Palomar;Gary D. Stormo;Pat Tedesco

  • Neurotoxic effects of TDP-43 overexpression in C. elegans

    Peter E.A. Ash;Yong Jie Zhang;Christine M. Roberts;Tassa Saldi

  • Interaction of intracellular β amyloid peptide with chaperone proteins

    Virginia Fonte;Wadim Jan Kapulkin;Andrew Taft;Amy Fluet

  • C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease.

    Christopher D. Link

  • Direct observation of stress response in Caenorhabditis elegans using a reporter transgene.

    Christopher D. Link;James R. Cypser;Carolyn J. Johnson;Thomas E. Johnson

  • Utility of an improved model of amyloid-beta (Aβ 1-42 ) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

    Gawain McColl;Blaine R Roberts;Tara L Pukala;Vijaya B Kenche;Vijaya B Kenche

  • A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans.

    Britta Leiers;Andreas Kampkötter;Christoph G Grevelding;Christopher D Link

  • Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.

    T. E. Johnson;S. Henderson;S. Murakami;E. de Castro

  • Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

    Yong Jie Zhang;Lin Guo;Patrick K. Gonzales;Tania F. Gendron

  • In Vivo Aggregation of β-Amyloid Peptide Variants

    David S. Fay;Amy Fluet;Carolyn J. Johnson;Christopher D. Link

Frequent Co-Authors

Thomas E. Johnson
Thomas E. Johnson University of Colorado Boulder
Michael A. Silverman
Michael A. Silverman Children's Hospital of Philadelphia
Tania F. Gendron
Tania F. Gendron Mayo Clinic
Rosa Rademakers
Rosa Rademakers University of Antwerp
D. Allan Butterfield
D. Allan Butterfield University of Kentucky
Stuart K. Kim
Stuart K. Kim Stanford University
Antonio Miranda-Vizuete
Antonio Miranda-Vizuete Spanish National Research Council
Thomas M. Laue
Thomas M. Laue University of New Hampshire

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