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Paul J. Thornalley

Paul J. Thornalley

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Biology and Biochemistry
Qatar
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
40806
World Ranking
1353
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Qatar Leader Award
  • 2025 - Research.com Biology and Biochemistry in Qatar Leader Award

Overview

Paul J. Thornalley is affiliated with Hamad bin Khalifa University in Qatar. Their research spans a diverse range of topics within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

The primary subfields of their work include Molecular Biology, Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Physiology, and Cancer Research. Their scientific contributions notably focus on themes such as Advanced Glycation End Products research, Adipose Tissue and Metabolism, Diabetes Management and Research, Biochemical effects in animals, Metabolism related to Diabetes and Cancer, COVID-19 Clinical Research Studies, and Pancreatic function in diabetes.

Frequent collaborators in their research include:

  • Naila Rabbani
  • Mingzhan Xue
  • Maryam Al-Motawa
  • Alberto de la Fuente
  • Essam M. Abdelalim

Significant publication venues where Thornalley has contributed multiple works include:

  • International Journal of Molecular Sciences
  • Diabetes Research and Clinical Practice
  • Redox Biology
  • Antioxidants
  • Building Resilience at Universities: Role of Innovation and Entrepreneurship

Recent notable papers authored or coauthored by Thornalley include:

  • "Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo," 2022, Nature Metabolism
  • "Protein glycation - biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine," 2021, Redox Biology
  • "Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation," 2021, Nutrients
  • "Dicarbonyl stress, protein glycation and the unfolded protein response," 2021, Glycoconjugate Journal
  • "Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis-Driver of Insulin Resistance and Development of Vascular Complications of Diabetes," 2022, International Journal of Molecular Sciences

Best Publications

  • Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose.

    Paul J. Thornalley;Annika Langborg;Harjit S. Minhas

  • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

    Paul J. Thornalley;Milan Vašák;Milan Vašák

  • Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

    T. W. C. Lo;M. E. Westwood;A. C. Mclellan;T. Selwood

  • The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.

    P J Thornalley

  • Unraveling the biological roles of reactive oxygen species.

    Michael P. Murphy;Arne Holmgren;Nils Göran Larsson;Barry Halliwell

  • Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

    Paul J Thornalley;Sinan Battah;Naila Ahmed;Nikolaos Karachalias

  • Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts.

    Paul J Thornalley

  • Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

    Paul J. Thornalley

  • Glyoxalase I – structure, function and a critical role in the enzymatic defence against glycation

    P.J. Thornalley

  • The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

    Susan A. Phillips;Paul J. Thornalley

  • Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

    Moritsugu Shinohara;P. J. Thornalley;Ida Giardino;Paul Beisswenger

  • Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.

    Antony C. McLellan;Paul J. Thornalley;Jonathan Benn;Peter H. Sonksen

  • The glyoxalase system in health and disease.

    Paul J. Thornalley

  • Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs.

    Thornalley Pj

  • Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

    Roya Babaei-Jadidi;Nikolaos Karachalias;Naila Ahmed;Sinan Battah

  • Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease

    Paul J. Thornalley

  • Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

    Angelika Bierhaus;Thomas Fleming;Stoyan Stoyanov;Andreas Leffler;Andreas Leffler

  • Dicarbonyl intermediates in the maillard reaction

    Paul J. Thornalley

  • Advanced glycation endproducts: what is their relevance to diabetic complications?

    N. Ahmed;P. J. Thornalley

  • Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin.

    Naila Ahmed;Ognian K Argirov;Harjit S Minhas;Carlos A A Cordeiro

Frequent Co-Authors

Naila Rabbani
Naila Rabbani Qatar University
Peter P. Nawroth
Peter P. Nawroth Heidelberg University
Angelika Bierhaus
Angelika Bierhaus Heidelberg University
Arnold Stern
Arnold Stern New York University
Michael Brownlee
Michael Brownlee Albert Einstein College of Medicine
Ian Clark
Ian Clark Rothamsted Research
Yves Henrotin
Yves Henrotin University of Liège
Allen Taylor
Allen Taylor Tufts University
Martin Zeier
Martin Zeier University Hospital Heidelberg
Peter H. Sönksen
Peter H. Sönksen King's College London

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