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Microbiology

D-Index
70
Citations
18949
World Ranking
1926
National Ranking
814

Overview

Klaus Strebel is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in the fields of Immunology and Microbiology, with a focus on Medicine. Their work spans subfields such as Virology, Immunology, Infectious Diseases, Molecular Biology, and Epidemiology.

The main topics addressed in Klaus Strebel's research include:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Interferon and immune responses
  • Immune Cell Function and Interaction
  • Ubiquitin and proteasome pathways
  • RNA Interference and Gene Delivery
  • RNA modifications and cancer

Klaus Strebel has published in a variety of scientific venues, with frequent contributions to:

  • Journal of Virology
  • mBio
  • Viruses
  • UNC Libraries
  • Nature Communications

Some of the recent papers featuring Klaus Strebel's research include:

  • Antiviral Activity and Adaptive Evolution of Avian Tetherins, 2020, Journal of Virology
  • Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells, 2024, Nature Communications
  • Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta, 2020, Journal of Virology
  • The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter, 2022, Journal of Virology
  • HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein, 2023, mBio

Frequent collaborators of Klaus Strebel include:

  • Eri Miyagi
  • Sandra Kao
  • Helena Fábryová
  • Sayaka Sukegawa
  • Hideki Saito

The collective research contributions of Klaus Strebel cover detailed investigations into viral-host interactions, particularly with HIV-1, exploring mechanisms such as viral protein function, immune cell response modulation, and antiviral defense systems. This extensive body of work contributes to ongoing efforts in HIV/AIDS drug development and understanding cellular processes relevant to infectious diseases and immune system functioning.

Best Publications

  • A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

    Florence Margottin;Stephan P Bour;Hervé Durand;Luc Selig

  • Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.

    R L Willey;F Maldarelli;M A Martin;K Strebel

  • The HIV 'A' (sor) gene product is essential for virus infectivity.

    Klaus Strebel;Daryl Daugherty;Kathleen Clouse;David Cohen

  • The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.

    T Klimkait;K Strebel;M D Hoggan;M A Martin

  • A novel gene of HIV-1, vpu, and its 16-kilodalton product.

    Klaus Strebel;Thomas Klimkait;Malcolm A. Martin

  • HIV-1 Vif, APOBEC, and intrinsic immunity.

    Ritu Goila-Gaur;Klaus Strebel

  • The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.

    Sandra Kao;Mohammad A. Khan;Eri Miyagi;Ron Plishka

  • Nucleotide sequence and genome organization of foot-and-mouth disease virus

    S. Forss;K. Strebel;E. Beck;H. Schaller

  • CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway

    Ulrich Schubert;Luis C. Antón;Igor Bačík;Josephine H. Cox

  • Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.

    K Strebel;T Klimkait;F Maldarelli;M A Martin

  • The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.

    U Schubert;S Bour;A V Ferrer-Montiel;M Montal

  • Characterization of foot-and-mouth disease virus gene products with antisera against bacterially synthesized fusion proteins.

    K Strebel;E Beck;K Strohmaier;H Schaller

  • Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV‐1‐infected cells

    Ulrich Schubert;Antonio V. Ferrer-Montiel;Myrta Oblatt-Montal;Peter Henklein

  • Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.

    R L Willey;F Maldarelli;M A Martin;K Strebel

  • Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion.

    Eri Miyagi;Amy J. Andrew;Sandra Kao;Klaus Strebel

  • Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.

    F. Maldarelli;Mao-Yuan Chen;R. L. Willey;K. Strebel

  • A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

    Hongzhan Xu;Evguenia S. Svarovskaia;Rebekah Barr;Yijun Zhang

  • Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.

    U Schubert;K Strebel

  • Guidelines for naming nonprimate APOBEC3 genes and proteins.

    Rebecca S. LaRue;Valgerdur Andrésdóttir;Yannick Blanchard;Silvestro G. Conticello

  • The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.

    S Bour;U Schubert;K Strebel

Frequent Co-Authors

Frank Maldarelli
Frank Maldarelli National Institutes of Health
Malcolm A. Martin
Malcolm A. Martin National Institutes of Health
Alicia Buckler-White
Alicia Buckler-White National Institutes of Health
Akio Adachi
Akio Adachi Kansai Medical University
Vinay K. Pathak
Vinay K. Pathak National Institutes of Health
Thomas Klimkait
Thomas Klimkait University of Basel
Michael Emerman
Michael Emerman Fred Hutchinson Cancer Research Center
Kuan-Teh Jeang
Kuan-Teh Jeang National Institutes of Health
Andrew M. L. Lever
Andrew M. L. Lever University of Cambridge
Ben Berkhout
Ben Berkhout University of Amsterdam

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