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Microbiology

D-Index
66
Citations
17797
World Ranking
2368
National Ranking
962

Overview

Frank Maldarelli is affiliated with the National Institutes of Health in the United States. Their research focuses predominantly on HIV and associated infectious diseases, with substantial contributions to the fields of Medicine and Immunology and Microbiology.

The scientist's work covers several subfields including Infectious Diseases, Virology, Immunology, Epidemiology, and Molecular Biology. These areas form the foundation for their extensive study of HIV/AIDS, immune cell function, and related viral complications.

Key topics in Maldarelli's research portfolio include:

  • HIV Research and Treatment
  • HIV/AIDS Drug Development and Treatment
  • HIV/AIDS Research and Interventions
  • Immune Cell Function and Interaction
  • HIV-related Health Complications and Treatments
  • Cytomegalovirus and Herpesvirus Research
  • Monoclonal and Polyclonal Antibodies Research

Their frequently published work appears notably in journals and platforms such as Viruses, bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Journal of Clinical Investigation, and Journal of Virus Eradication.

Frequent co-authors collaborating with Maldarelli include:

  • Robert J. Gorelick
  • Mary F. Kearney
  • Chuen-Yen Lau
  • Nicolas Chomont
  • John M. Coffin

Representative papers authored or co-authored by Frank Maldarelli include:

  • "Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy," 2022, Science Translational Medicine
  • "Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy," 2021, PLoS Pathogens
  • "Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections," 2020, Viruses
  • "Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption," 2020, Journal of Clinical Investigation
  • "Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection," 2021, Viruses

Best Publications

  • Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

    F. Maldarelli;X. Wu;L. Su;F. R. Simonetti

  • Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.

    R L Willey;F Maldarelli;M A Martin;K Strebel

  • Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

    Sarah Palmer;Frank Maldarelli;Ann Wiegand;Barry Bernstein

  • New Real-Time Reverse Transcriptase-Initiated PCR Assay with Single-Copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma

    Sarah Palmer;Ann P. Wiegand;Frank Maldarelli;Holly Bazmi

  • Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

    Stephen A. Migueles;Christine M. Osborne;Cassandra Royce;Alex A. Compton

  • Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-Experienced Patients Are Missed by Standard Genotype Analysis

    Sarah Palmer;Mary Kearney;Frank Maldarelli;Elias K. Halvas

  • Towards an HIV cure: a global scientific strategy

    Steven G Deeks;Brigitte Autran;Ben Berkhout;Monsef Benkirane

  • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

    J. B. Dinoso;S. Y. Kim;A. M. Wiegand;S. E. Palmer;S. E. Palmer

  • B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

    Frank Maldarelli;Xiaolin Wu;Ling Su;Francesco Simonetti

  • Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

    Francesco R. Simonetti;Michele D. Sobolewski;Elizabeth Fyne;Wei Shao

  • ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia

    Frank Maldarelli;Sarah Palmer;Martin S King;Ann Wiegand

  • Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.

    K Strebel;T Klimkait;F Maldarelli;M A Martin

  • Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

    Jintanat Ananworanich;Alexandra Schuetz;Claire Vandergeeten;Irini Sereti

  • Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.

    R L Willey;F Maldarelli;M A Martin;K Strebel

  • Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

    Donn J. Colby;Lydie Trautmann;Lydie Trautmann;Suteeraporn Pinyakorn;Suteeraporn Pinyakorn;Louise Leyre

  • Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.

    F. Maldarelli;Mao-Yuan Chen;R. L. Willey;K. Strebel

  • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy

    D. McMahon;J. Jones;A. Wiegand;S. J. Gange

  • Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy

    Mary F. Kearney;Jonathan Spindler;Wei Shao;Sloane Yu

  • Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

    Christine Neuveut;Kenneth G. Low;Frank Maldarelli;Iris Schmitt

  • Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation.

    F Maldarelli;M A Martin;K Strebel

  • Human Immunodeficiency Virus Type 1 Population Genetics and Adaptation in Newly Infected Individuals

    M. Kearney;M. Kearney;F. Maldarelli;W. Shao;J. B. Margolick

Frequent Co-Authors

John M. Coffin
John M. Coffin Tufts University
Mary F. Kearney
Mary F. Kearney National Institutes of Health
John W. Mellors
John W. Mellors University of Pittsburgh
Sarah Palmer
Sarah Palmer University of Sydney
Klaus Strebel
Klaus Strebel National Institutes of Health
Irini Sereti
Irini Sereti National Institutes of Health
Stephen Hughes
Stephen Hughes National Cancer Institute
Julia A. Metcalf
Julia A. Metcalf National Institute of Allergy and Infectious Diseases
Vinay K. Pathak
Vinay K. Pathak National Institutes of Health
Robert Yarchoan
Robert Yarchoan National Institutes of Health

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