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Biology and Biochemistry

D-Index
71
Citations
17201
World Ranking
6683
National Ranking
479

Overview

Klemens Rottner is affiliated with Technische Universität Braunschweig in Germany and has an extensive publication record primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research contributions reflect a focus on Cell Biology and Molecular Biology, with additional work related to Immunology and Biophysics.

Their main research topics span Cellular Mechanics and Interactions, Cell Adhesion Molecules Research, Advanced Fluorescence Microscopy Techniques, Microtubule and Mitosis Dynamics, Cardiomyopathy and Myosin Studies, Cellular Transport and Secretion, and RNA Research and Splicing.

Rottner has published in a variety of scientific venues, with a significant number of works appearing in bioRxiv (Cold Spring Harbor Laboratory), Current Biology, European Journal of Cell Biology, Journal of Cell Science, and The Journal of Cell Biology.

Frequent collaborators in their research include Theresia E. B. Stradal, Matthias Schaks, Anika Steffen, Jan Faix, and Christopher Lambert.

Among their recent papers are:

  • "WAVE regulatory complex," 2021, Current Biology
  • "Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion," 2020, eLife
  • "A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks," 2021, Nature Communications
  • "Global mapping of Salmonella enterica-host protein-protein interactions during infection," 2021, Cell Host & Microbe
  • "Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase," 2022, Nature Communications

Best Publications

  • The lamellipodium: where motility begins

    J.Victor Small;Theresia Stradal;Emmanuel Vignal;Klemens Rottner

  • Interplay between Rac and Rho in the control of substrate contact dynamics

    K. Rottner;A. Hall;J.V. Small

  • Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation

    Anika Steffen;Klemens Rottner;Julia Ehinger;Metello Innocenti

  • The making of filopodia

    Jan Faix;Klemens Rottner

  • VASP dynamics during lamellipodia protrusion.

    K Rottner;B Behrendt;J V Small;J Wehland

  • Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

    Irina Kaverina;Klemens Rottner;J. Victor Small

  • Arp2/3 complex interactions and actin network turnover in lamellipodia

    Frank P L Lai;Malgorzata Szczodrak;Jennifer Block;Jan Faix

  • Assembling an actin cytoskeleton for cell attachment and movement

    J V Small;K Rottner;I Kaverina;K I Anderson

  • Regulation of actin dynamics by WASP and WAVE family proteins.

    Theresia E.B. Stradal;Klemens Rottner;Andrea Disanza;Stefano Confalonieri

  • Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N‐WASP‐defective cells

    Silvia Lommel;Stefanie Benesch;Klemens Rottner;Thomas Franz

  • Filopodia Formation in the Absence of Functional WAVE and Arp2/3 Complexes

    Anika Steffen;Jan Faix;Guenter P. Resch;Joern Linkner

  • Actin assembly mechanisms at a glance.

    Klemens Rottner;Jan Faix;Sven Bogdan;Stefan Linder

  • Actin dynamics in cell migration.

    Matthias Schaks;Grégory Giannone;Grégory Giannone;Klemens Rottner

  • Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement.

    A. Disanza;A. Steffen;M. Hertzog;E. Frittoli

  • Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

    Metello Innocenti;Silke Gerboth;Klemens Rottner;Frank P. L. Lai

  • Inhibitory signalling to the Arp2/3 complex steers cell migration

    Irene Dang;Roman Gorelik;Carla Sousa-Blin;Emmanuel Derivery

  • Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front.

    Stefan A. Koestler;Sonja Auinger;Marlene Vinzenz;Klemens Rottner

  • Functional design in the actin cytoskeleton

    J Victor Small;Klemens Rottner;Irina Kaverina

  • MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.

    Anika Steffen;Anika Steffen;Gaëlle Le Dez;Gaëlle Le Dez;Renaud Poincloux;Renaud Poincloux;Chiara Recchi;Chiara Recchi

  • Actin dynamics and turnover in cell motility.

    Klemens Rottner;Theresia E B Stradal

Frequent Co-Authors

Theresia E. B. Stradal
Theresia E. B. Stradal Helmholtz Centre for Infection Research
Jan Faix
Jan Faix Hannover Medical School
J. Victor Small
J. Victor Small Austrian Academy of Sciences
Michael Sixt
Michael Sixt Institute of Science and Technology Austria
Cord Brakebusch
Cord Brakebusch University of Copenhagen
Jürgen Wehland
Jürgen Wehland Technische Universität Braunschweig
Laurent Blanchoin
Laurent Blanchoin Grenoble Alpes University
Giorgio Scita
Giorgio Scita FIRC Institute of Molecular Oncology
Dietmar Vestweber
Dietmar Vestweber Max Planck Society
Robert Geffers
Robert Geffers Helmholtz Centre for Infection Research

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