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Biology and Biochemistry

D-Index
88
Citations
24819
World Ranking
2739
National Ranking
29

Overview

Cord Brakebusch is affiliated with the University of Copenhagen in Denmark and has a substantial body of research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields, including Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Surgery, and Genetics.

The scientist's research focuses on complex biological processes with special attention to CRISPR and Genetic Engineering, Cellular Mechanics and Interactions, Neuroinflammation and Neurodegeneration Mechanisms, Neuroscience and Neuropharmacology Research, Immune cells in cancer, Nerve injury and regeneration, and Signaling Pathways in Disease.

Notable recent papers by Brakebusch include:

  • "RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury," 2021, published in Neuron
  • "Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration," 2020, published in Cell Reports
  • "Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation," 2022, published in Gut
  • "Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?", 2020, published in Cells
  • "ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells," 2021, published in PLoS Genetics

Brakebusch frequently collaborates with several researchers, including:

  • João B. Relvas
  • Renato Socodato
  • Camila C. Portugal
  • Teresa Canedo
  • Tiago O. Almeida

The scientist's research has been published in multiple venues, with recurring publications in:

  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • SSRN Electronic Journal
  • Neuron

Best Publications

  • Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

    D Aderka;H Engelmann;Y Maor;C Brakebusch

  • The integrin-actin connection, an eternal love affair

    Cord Brakebusch;Reinhard Fässler

  • Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen

    Bernhard Nieswandt;Cord Brakebusch;Wolfgang Bergmeier;Valerie Schulte

  • Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

    Y Nophar;O Kemper;C Brakebusch;H Englemann

  • Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

    H Engelmann;H Holtmann;C Brakebusch;Y S Avni

  • Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes

    Cord Brakebusch;Richard Grose;Fabio Quondamatteo;Angel Ramirez

  • Fetal and Adult Hematopoietic Stem Cells Require β1 Integrin Function for Colonizing Fetal Liver, Spleen, and Bone Marrow

    Alexandre J Potocnik;Alexandre J Potocnik;Cord Brakebusch;Reinhard Fässler

  • The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

    Silvia Cappello;Alessio Attardo;Xunwei Wu;Takuji Iwasato

  • The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

    Erik H.J. Danen;Petra Sonneveld;Cord Brakebusch;Reinhard Fässler

  • Rho GTPase function in tumorigenesis.

    R Karlsson;Esben Ditlev Kølle Pedersen;Zhipeng Wang;Cord Brakebusch

  • A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.

    Richard Grose;Caroline Hutter;Wilhelm Bloch;Irmgard Thorey

  • Mac‐2 binding protein is a cell‐adhesive protein of the extracellular matrix which self‐assembles into ring‐like structures and binds β1 integrins, collagens and fibronectin

    Takako Sasaki;Cord Brakebusch;Jürgen Engel;Rupert Timpl

  • β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

    Attila Aszodi;Ernst B. Hunziker;Cord Brakebusch;Reinhard Fässler

  • β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

    Lia S. Campos;Dino P. Leone;Joao B. Relvas;Cord Brakebusch

  • Integrins in invasive growth.

    Cord Brakebusch;Daniel Bouvard;Fabio Stanchi;Takao Sakai

  • The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

    K Iba;R Albrechtsen;B Gilpin;Camilla Frohlich

  • Functional Consequences of Integrin Gene Mutations in Mice

    Daniel Bouvard;Cord Brakebusch;Erika Gustafsson;Attila Aszódi

  • Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

    Sebastian A. Wagner;Sebastian A. Wagner;Petra Beli;Brian T. Weinert;Christian Schölz

  • Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

    Wilko D. Altrock;Susanne tom Dieck;Susanne tom Dieck;Maxim Sokolov;Alexander C. Meyer

  • Cdc42 regulates cofilin during the establishment of neuronal polarity

    Boyan K. Garvalov;Kevin C. Flynn;Dorothee Neukirchen;Liane Meyn

Frequent Co-Authors

David Wallach
David Wallach Weizmann Institute of Science
Reinhard Fässler
Reinhard Fässler Max Planck Society
Klemens Rottner
Klemens Rottner Technische Universität Braunschweig
Bernhard Nieswandt
Bernhard Nieswandt University of Würzburg
Thomas Krieg
Thomas Krieg University of Cologne
Theresia E. B. Stradal
Theresia E. B. Stradal Helmholtz Centre for Infection Research
Ueli Suter
Ueli Suter École Polytechnique Fédérale de Lausanne
Stefan Offermanns
Stefan Offermanns Max Planck Society
Eckart D. Gundelfinger
Eckart D. Gundelfinger Leibniz Institute for Neurobiology
Constanze I. Seidenbecher
Constanze I. Seidenbecher Leibniz Institute for Neurobiology

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