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Biology and Biochemistry

D-Index
60
Citations
14172
World Ranking
11873
National Ranking
307

Overview

Sjaak Philipsen is affiliated with Erasmus University Rotterdam in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, contributing significantly within these domains.

The main subfields in which Philipsen conducts research include Molecular Biology, Genetics, Hematology, Physiology, and Pediatrics, Perinatology and Child Health. This work addresses various biomedical and molecular mechanisms, emphasizing hematological function and genetic regulation.

Their research topics cover:

  • Hemoglobinopathies and Related Disorders
  • Erythrocyte Function and Pathophysiology
  • Prenatal Screening and Diagnostics
  • Kruppel-like factors research
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research
  • CRISPR and Genetic Engineering

Some notable recent publications by Sjaak Philipsen include:

  • PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells, 2020, Biomaterials
  • Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice, 2023, Nature Communications
  • An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells, 2020, Blood
  • Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases, 2022, Frontiers in Genome Editing
  • Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency, 2021, Blood Advances

Philipsen frequently publishes in venues such as:

  • Blood
  • Nature Communications
  • Frontiers in Genome Editing
  • Haematologica
  • bioRxiv (Cold Spring Harbor Laboratory)

Collaboration is an important component of their work, with frequent co-authors including:

  • Nynke Gillemans
  • Frank Grosveld
  • Wilfred F. J. van IJcken
  • Emile van den Akker
  • Thijs C. J. Verheul

Best Publications

  • A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

    Sjaak Philipsen;Guntram Suske

  • Gene expression-based classification of non-small cell lung carcinomas and survival prediction.

    Jun Hou;Joachim Aerts;Bianca den Hamer;Wilfred van IJcken

  • Transcription Factor Sp1 Is Essential for Early Embryonic Development but Dispensable for Cell Growth and Differentiation

    Marisol Marin;Alar Karis;Pim Visser;Frank Grosveld

  • Regulation of the activity of Sp1-related transcription factors

    Peter Bouwman;Sjaak Philipsen

  • GATA1 function, a paradigm for transcription factors in hematopoiesis.

    Rita Ferreira;Kinuko Ohneda;Masayuki Yamamoto;Sjaak Philipsen

  • Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

    Joseph Borg;Petros Papadopoulos;Marianthi Georgitsi;Laura Gutiérrez

  • Erythropoiesis: Development and Differentiation

    Elaine Dzierzak;Sjaak Philipsen

  • The role of EKLF in human beta-globin gene competition.

    Mark Wijgerde;Joost Gribnau;Tolleiv Trimborn;Beatriz Nuez

  • A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

    J. Ellis;K. C. Tan-Un;A. Harper;D. Michalovich

  • Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

    Erik Engelen;Umut Akinci;Jan Christian Bryne;Jun Hou

  • Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

    Michelle A. Christensen;Weihui Zhou;Hong Qing;Anna Lehman

  • Transcription factor Sp3 is essential for post-natal survival and late tooth development.

    Peter Bouwman;Heike Göllner;Hans-Peter Elsässer;Gabriele Eckhoff

  • Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.

    Sten F. W. M. Libregts;Laura Gutierrez;Alexander M. de Bruin;Felix M. Wensveen

  • Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the α globin cluster

    Jonathan Flint;Cristina Tufarelli;John Peden;Kevin Clark

  • The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

    Roy Drissen;Marieke von Lindern;Andrea Kolbus;Siska Driegen

  • Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

    Belinda Giardine;Joseph Borg;Joseph Borg;Douglas R Higgs;Kenneth R Peterson

  • Impaired ossification in mice lacking the transcription factor Sp3.

    Heike Göllner;Christian Dani;Blaine Phillips;Sjaak Philipsen

  • Krüppeling erythropoiesis: An unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

    Andrew Perkins;Xiangmin Xu;Douglas R. Higgs;George P. Patrinos

  • Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells

    Dorota Kurek;Alex Neagu;Melodi Tastemel;Nesrin Tüysüz

  • Chtop is a component of the dynamic TREX mRNA export complex.

    Chung Te Chang;Guillaume M. Hautbergue;Matthew J. Walsh;Nicolas Viphakone

Frequent Co-Authors

Frank Grosveld
Frank Grosveld Erasmus University Rotterdam
Guntram Suske
Guntram Suske Philipp University of Marburg
George P. Patrinos
George P. Patrinos University of Patras
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Rita Tewari
Rita Tewari University of Nottingham
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Swee Lay Thein
Swee Lay Thein King's College London
Douglas R. Higgs
Douglas R. Higgs University of Oxford

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