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Genetics

D-Index
81
Citations
31018
World Ranking
1505
National Ranking
191

Medicine

D-Index
85
Citations
32935
World Ranking
14448
National Ranking
1333

Overview

Swee Lay Thein is affiliated with King's College London in the United Kingdom. Their research primarily focuses on topics within the field of Medicine, with significant contributions in Genetics, Hematology, Physiology, Molecular Biology, and Cell Biology. Thein's work extensively covers areas related to hemoglobinopathies, iron metabolism, erythrocyte function, and blood transfusion practices.

Thein has a number of frequent coauthors who have collaborated on multiple projects. These include Anna Conrey, William A. Eaton, Xunde Wang, Emily B. Dunkelberger, and Neal Jeffries. Their collaborations reflect a strong network of experts in hematology and related biomedical sciences.

The scientist has published prolifically in several key venues known for research in hematology and blood disorders. Prominent publication venues include Blood, Blood Advances, Haematologica, British Journal of Haematology, and bioRxiv (Cold Spring Harbor Laboratory).

Thein's recent papers cover a range of topics crucial to sickle cell disease and related disorders. Notable recent publications include:

  • "American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support" (2020, Blood Advances)
  • "Recent Advances in the Treatment of Sickle Cell Disease" (2020, Frontiers in Physiology)
  • "Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease" (2021, Blood)
  • "Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin" (2021, Blood)
  • "Treating sickle cell anemia" (2020, Science)

Thein's research spans important topics such as Hemoglobinopathies and Related Disorders, Iron Metabolism and Disorders, Erythrocyte Function and Pathophysiology, Blood Groups and Transfusion, Epigenetics and DNA Methylation, RNA Modifications and Cancer, and Hemoglobin Structure and Function.

Best Publications

  • Hypervariable 'minisatellite' regions in human DNA.

    Alec J. Jeffreys;Victoria Wilson;Swee Lay Thein

  • Individual-specific 'fingerprints' of human DNA.

    A. J. Jeffreys;V. Wilson;S. L. Thein

  • Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR

    Nicholas Silver;Steve Best;Jie Jiang;Swee Lay Thein

  • A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

    Stephan Menzel;Chad Garner;Ivo Gut;Fumihiko Matsuda

  • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

    Nicole Soranzo;Nicole Soranzo;Tim D Spector;Massimo Mangino;Brigitte Kühnel

  • New gene functions in megakaryopoiesis and platelet formation

    Christian Gieger;Aparna Radhakrishnan;Ana Cvejic;Weihong Tang

  • American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.

    Stella T. Chou;Mouaz Alsawas;Ross M. Fasano;Joshua J. Field

  • Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

    Santhi K. Ganesh;Santhi K. Ganesh;Neil A. Zakai;Frank J A Van Rooij;Nicole Soranzo;Nicole Soranzo

  • The Molecular Basis of β-Thalassemia

    Swee Lay Thein

  • DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees.

    Alec J. Jeffreys;Victoria Wilson;Swee Lay Thein;David J. Weatherall

  • Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.

    Swee Lay Thein;Stephan Menzel;Xu Peng;Steve Best

  • Genetic influences on F cells and other hematologic variables: a twin heritability study.

    C. Garner;T. Tatu;J. E. Reittie;T. Littlewood

  • Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias.

    Maria Domenica Cappellini;John Porter;Amal El-Beshlawy;Chi Kong Li

  • Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.

    D A Lane;T Bayston;R J Olds;A C Fitches

  • Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms.

    J S Wainscoat;A V Hill;A L Boyce;J Flint

  • Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

    Swee Lay Thein;Stephan Menzel;Mark Lathrop;Chad Garner

  • Cloning a selected fragment from a human DNA ‘fingerprint’: isolation of an extremely polymorphic minisatellite

    Zilla Wong;Victoria Wilson;Alec J. Jeffreys;Swee Lay Thein

  • Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

    S Sumi;A M Marinaki;M Arenas;L Fairbanks

  • Molecular basis for dominantly inherited inclusion body beta-thalassemia.

    S L Thein;C Hesketh;P Taylor;I J Temperley

  • Genetic modifiers of beta-thalassemia.

    Swee Lay Thein

Frequent Co-Authors

Tim D. Spector
Tim D. Spector King's College London
Anne Greenough
Anne Greenough King's College London
David J. Weatherall
David J. Weatherall University of Oxford
Nicole Soranzo
Nicole Soranzo Wellcome Sanger Institute
Douglas R. Higgs
Douglas R. Higgs University of Oxford
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge
Fenella J. Kirkham
Fenella J. Kirkham University College London
Martin Farrall
Martin Farrall University of Oxford
Mark Lathrop
Mark Lathrop McGill University
William G. Wood
William G. Wood University of Oxford

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