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Genetics
UK
2024
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
108
Citations
38687
World Ranking
567
National Ranking
87

Molecular Biology

D-Index
108
Citations
38687
World Ranking
400
National Ranking
25

Medicine

D-Index
109
Citations
43051
World Ranking
5788
National Ranking
569

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2005 - Fellow of the Royal Society, United Kingdom

Overview

Douglas R. Higgs is affiliated with the University of Oxford in the United Kingdom and specializes in biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their research spans molecular biology, genetics, physiology, plant science, and hematology, with a focus on genomics and chromatin dynamics, RNA research and splicing, hemoglobinopathies and related disorders, RNA modifications and cancer, erythrocyte function and pathophysiology, epigenetics and DNA methylation, and RNA and protein synthesis mechanisms.

Recent publications by Douglas R. Higgs include:

  • The relationship between genome structure and function (2020, Nature Reviews Genetics)
  • Defining genome architecture at base-pair resolution (2021, Nature)
  • Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder (2020, Cell Stem Cell)
  • Super-enhancers include classical enhancers and facilitators to fully activate gene expression (2023, Cell)
  • Dynamics of the 4D genome during in vivo lineage specification and differentiation (2020, Nature Communications)

Frequent co-authors collaborating with Douglas R. Higgs include Jim R. Hughes, Christian Babbs, Mira Kassouf, A. Marieke Oudelaar, and Damien J. Downes.

Publication venues where Douglas R. Higgs has frequently contributed consist of bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Blood, Nature Reviews Genetics, and Experimental Hematology.

Douglas R. Higgs has been recognized as a Fellow of the Royal Society, United Kingdom, since 2005.

Best Publications

  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

    Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis

  • THE POLYCYSTIC KIDNEY-DISEASE-1 GENE ENCODES A 14-KB TRANSCRIPT AND LIES WITHIN A DUPLICATED REGION ON CHROMOSOME-16

    Christopher Ward;Belén Peral;Jim Hughes;Siep Thomas

  • A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

    S. T. Reeders;M. H. Breuning;K. E. Davies;R. D. Nicholls

  • A review of the molecular genetics of the human alpha-globin gene cluster.

    Higgs;M A Vickers;A O Wilkie;I M Pretorius

  • Molecular basis for mild forms of homozygous beta-thalassaemia

    D J Weatherall;L Pressley;W G Wood;Higgs

  • Mutations in a Putative Global Transcriptional Regulator Cause X-linked Mental Retardation With Alpha-Thalassemia (ATR-X Syndrome)

    Richard J Gibbons;David J Picketts;Laurent Villard;Douglas R Higgs

  • Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease.

    Cristina Tufarelli;Jackie A Sloane Stanley;David Garrick;Jackie A Sharpe

  • Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia

    Samuel S. Chong;Corinne D. Boehm;Corinne D. Boehm;Douglas R. Higgs;Douglas R. Higgs;Garry R. Cutting;Garry R. Cutting

  • Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

    Martin H. Steinberg;Bernard G. Forget;Douglas R. Higgs;David J. Weatherall

  • Mutations in ATRX , encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

    Richard J. Gibbons;Tarra L. McDowell;Sundhya Raman;Delia M. O'Rourke

  • Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

    Jim R Hughes;Nigel Roberts;Simon McGowan;Deborah Hay

  • Alpha-thalassaemia caused by a polyadenylation signal mutation.

    D. R. Higgs;S. E. Y. Goodbourn;J. Lamb;J. B. Clegg

  • ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

    Martin J. Law;Karen M. Lower;Hsiao P.J. Voon;Jim R. Hughes

  • Considerations when investigating lncRNA function in vivo

    Andrew R Bassett;Asifa Akhtar;Denise P Barlow;Adrian P Bird

  • The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

    Yutong Xue;Richard Gibbons;Zhijiang Yan;Dafeng Yang

  • Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    Jenny C. Taylor;Jenny C. Taylor;Hilary C. Martin;Stefano Lise;John Broxholme

  • A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter

    Marco De Gobbi;Vip Viprakasit;Jim R Hughes;Chris Fisher

  • The Interaction of Alpha-Thalassemia and Homozygous Sickle-Cell Disease

    Douglas R. Higgs;Beverley E. Aldridge;Janette Lamb;John B. Clegg

  • Recombination at the human α-globin gene cluster: Sequence features and topological constraints

    R.D. Nicholls;N. Fischel-Ghodsian;D.R. Higgs

  • Genetic dissection of the α-globin super-enhancer in vivo

    Deborah Hay;Jim R. Hughes;Christian Babbs;James O.J. Davies

Frequent Co-Authors

Richard J. Gibbons
Richard J. Gibbons University of Oxford
William G. Wood
William G. Wood University of Oxford
James Hughes
James Hughes Emory University
David J. Weatherall
David J. Weatherall University of Oxford
Veronica J. Buckle
Veronica J. Buckle University of Oxford
Paresh Vyas
Paresh Vyas University of Oxford
Andrew O.M. Wilkie
Andrew O.M. Wilkie University of Oxford
John B. Clegg
John B. Clegg John Radcliffe Hospital
Jonathan Flint
Jonathan Flint University of California, Los Angeles
Peter C. Harris
Peter C. Harris Mayo Clinic

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