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Biology and Biochemistry

D-Index
59
Citations
15610
World Ranking
12375
National Ranking
56

Overview

Fernando F. Costa is affiliated with the State University of Campinas in Brazil. Their research primarily focuses on the fields of Medicine, with significant contributions within Genetics, Hematology, Molecular Biology, Physiology, and Pediatrics, Perinatology and Child Health.

The scientist has a strong record of publications, showing active engagement in major research topics including:

  • Hemoglobinopathies and Related Disorders
  • Iron Metabolism and Disorders
  • Erythrocyte Function and Pathophysiology
  • Blood groups and transfusion
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Heme Oxygenase-1 and Carbon Monoxide
  • Prenatal Screening and Diagnostics

Fernando F. Costa has authored numerous papers with notable recent examples including:

  • Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission (2023, The Lancet Haematology)
  • Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria (2020, Hematology Transfusion and Cell Therapy)
  • High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia (2020, Annals of Hematology)
  • Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner (2023, British Journal of Haematology)
  • Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers (2020, Bioorganic Chemistry)

The scientist frequently publishes in prominent journals:

  • Blood (35 publications)
  • Hematology Transfusion and Cell Therapy (9 publications)
  • Annals of Hematology (7 publications)
  • British Journal of Haematology (7 publications)
  • Experimental Biology and Medicine (6 publications)

Collaboration is a key aspect of their work, having worked extensively with the following frequent co-authors:

  • Dulcinéia Martins de Albuquerque (24 publications)
  • Carolina Lanaro (21 publications)
  • Nicola Conran (20 publications)
  • Sara Teresinha Olalla Saad (20 publications)
  • Flávia C. Leonardo (18 publications)

Best Publications

  • The genome sequence of the plant pathogen Xylella fastidiosa

    A. J.G. Simpson;F. C. Reinach;P. Arruda;F. A. Abreu

  • Sickle cell disease

    Gregory J Kato;Frédéric B Piel;Clarice D Reid;Marilyn H Gaston

  • DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

    Guillaume Lettre;Vijay G. Sankaran;Marcos André C. Bezerra;Aderson S. Araújo

  • The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.

    V R Arruda;P M von Zuben;L C Chiaparini;J M Annichino-Bizzacchi

  • Shotgun sequencing of the human transcriptome with ORF expressed sequence tags

    Emmanuel Dias Neto;Ricardo Garcia Correa;Sergio Verjovski-Almeida;Marcelo R.S. Briones

  • Optical tweezers for measuring red blood cell elasticity: application to the study of drug response in sickle cell disease.

    M. M. Brandão;A. Fontes;M. L. Barjas-Castro;L. C. Barbosa

  • Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease.

    Valder R Arruda;Joyce M Annichino-Bizzacchi;Marilda S Gonçalves;Fernando F Costa

  • Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

    C. Lanaro;C. F. Franco-Penteado;D. M. Albuqueque;S. T. O. Saad

  • An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

    Luciana M Hollanda;Carmen S P Lima;Anderson F Cunha;Dulcinéia M Albuquerque

  • Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-Occlusion

    Nicola Conran;Carla F Franco-Penteado;Fernando F Costa

  • The contribution of 700,000 ORF sequence tags to the definition of the human transcriptome

    Anamaria A. Camargo;Helena P. B. Samaia;Emmanuel Dias-Neto;Daniel F. Simão

  • Point mutation in the beta-spectrin gene associated with alpha I/74 hereditary elliptocytosis. Implications for the mechanism of spectrin dimer self-association.

    William T. Tse;Marie Christine Lecomte;Fernando F. Costa;Michel Garbarz

  • Prevalence of the Mutation C677 ® T in the Methylene Tetrahydrofolate Reductase Gene Among Distinct Ethnic Groups in Brazil

    V R Arruda;L H Siqueira;Marilda S Gonçalves;P M von Zuben

  • Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus.

    J C Winkelmann;F F Costa;B L Linzie;B G Forget

  • The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

    Helena Brentani;Otávia L. Caballero;Anamaria A. Camargo;Aline M. da Silva

  • Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

    Camila Bononi Almeida;Christoph Scheiermann;Jung Eun Jang;Jung Eun Jang;Colette Prophete

  • Effect of α-thalassemia and β-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil

    Maria Stella Figueiredo;José Kerbauy;M. S. Goncalves;V. R. Arruda

  • Factor V Leiden (FVQ 506) is common in a Brazilian population

    Valder R. Arruda;Joyce M. Annichino‐Bizzacchi;Fernando F. Costa;Pieter H. Reitsma

  • Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects.

    Valder Roberval Arruda;Carmen Silvia Passos Lima;Carlos Roberto Escrivão Grignoli;Mônica Barbosa De Melo

  • Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags

    Sandro J. de Souza;Anamaria A. Camargo;Marcelo R. S. Briones;Fernando F. Costa

Frequent Co-Authors

Sergio Verjovski-Almeida
Sergio Verjovski-Almeida Universidade de São Paulo
Gustavo H. Goldman
Gustavo H. Goldman Universidade de São Paulo
João Bosco Pesquero
João Bosco Pesquero Federal University of Sao Paulo
Valder R. Arruda
Valder R. Arruda University of Pennsylvania
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Marion E. Reid
Marion E. Reid New York Blood Center
Paul S. Frenette
Paul S. Frenette Albert Einstein College of Medicine
Ricardo R. Brentani
Ricardo R. Brentani Ludwig Cancer Research
Andrew J.G. Simpson
Andrew J.G. Simpson Ludwig Cancer Research
Swee Lay Thein
Swee Lay Thein King's College London

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