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Hideaki Kakeya

Hideaki Kakeya

D-Index & Metrics

Chemistry

D-Index
46
Citations
9547
World Ranking
15894
National Ranking
1251

Overview

Hideaki Kakeya is a researcher affiliated with Kyoto University in Japan. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, Kakeya's research focuses on specialized subfields including Molecular Biology, Pharmacology, Organic Chemistry, Biochemistry, and Spectroscopy.

Their research topics emphasize areas such as Microbial Natural Products and Biosynthesis, Chemical Synthesis and Analysis, Synthetic Organic Chemistry Methods, and Curcumin's Biomedical Applications. Additional topics include Click Chemistry and Applications, Amino Acid Enzymes and Metabolism, and Marine Sponges and Natural Products.

Hideaki Kakeya has published extensively, with notable recent papers including:

  • "Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity" (2023, Communications Chemistry)
  • "Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy" (2021, The Journal of Antibiotics)
  • "The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice" (2020, Scientific Reports)
  • "Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats" (2021, Nutrients)
  • "Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture" (2020, Chemistry - An Asian Journal)

Kakeya frequently publishes in several scientific venues, with the most common being:

  • The Journal of Antibiotics
  • The Journal of Organic Chemistry
  • Chemistry - An Asian Journal
  • ChemBioChem
  • Journal of Natural Products

The scientist collaborates regularly with a group of co-authors, including:

  • Takefumi Kuranaga
  • Hiroaki Ikeda
  • Shinichi Nishimura
  • Chengqian Pan
  • Kensuke Kaneko

Best Publications

  • RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

    Jean-Michel Fustin;Masao Doi;Yoshiaki Yamaguchi;Hayashi Hida

  • Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase☆

    Cheng-Bin Cui;Hideaki Kakeya;Hiroyuki Osada

  • Innovative preparation of curcumin for improved oral bioavailability.

    Hiroki Sasaki;Yoichi Sunagawa;Yoichi Sunagawa;Kenji Takahashi;Atsushi Imaizumi

  • Spirotryprostatin B, a Novel Mammalian Cell Cycle Inhibitor Produced by Aspergillus fumigatus

    Cheng-Bin Cui;Hideaki Kakeya;Hiroyuki Osada

  • Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B and Other Diketopiperazines Produced by Aspergillus fumigatus I. Taxonomy, Fermentation, Isolation and Biological Properties

    Cheng-Bin Cui;Hideaki Kakeya;Gen Okada;Rie Onose

  • A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.

    Naoko Takahashi-Ando;Makoto Kimura;Hideaki Kakeya;Hiroyuki Osada

  • Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures.

    Cheng-Bin Cui;Hideaki Kakeya;Hiroyuki Osada

  • Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

    Hideaki Kakeya;Isamu Takahashi;Gen Okada;Kiyoshi Isono

  • Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp.

    Kakeya H;Morishita M;Koshino H;Morita Ti

  • Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.

    Yukihiro Asami;Hideaki Kakeya;Rie Onose;Arika Yoshida

  • Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp.

    Hideaki Kakeya;Naoko Takahashi-Ando;Makoto Kimura;Rie Onose

  • Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone

    Hideaki Kakeya;Masayuki Morishita;Kimie Kobinata;Michiyo Osono

  • Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

    Shinichi Nishimura;Yuko Arita;Miyuki Honda;Kunihiko Iwamoto

  • Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

    Hideaki Kakeya;Naoko Sakai;Takeshi Sugai;Hiromichi Ohta

  • Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.

    Masaya Imoto;Hideaki Kakeya;Tsutomu Sawa;Chigusa Hayashi

  • Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.

    Yoko Nagumo;Hideaki Kakeya;Mitsuru Shoji;Yujiro Hayashi

  • Neuritogenic Effect of Epolactaene Derivatives on Human Neuroblastoma Cells Which Lack High-Affinity Nerve Growth Factor Receptors

    Hideaki Kakeya;Chizuko Onozawa;Masakazu Sato;Koshi Arai

  • Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

    Hideaki Kakeya;Rie Onose;Hiroyuki Koshino;Arika Yoshida

  • Total synthesis of (+)-epoxyquinols A and B.

    Mitsuru Shoji;Junichiro Yamaguchi;Hideaki Kakeya;Hiroyuki Osada

  • Caspase-mediated Activation of a 36-kDa Myelin Basic Protein Kinase during Anticancer Drug-induced Apoptosis

    Hideaki Kakeya;Rie Onose;Hiroyuki Osada

  • Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus.

    C.‐B. Cui;H. Kakeya;G. Okada;R. Onose

Frequent Co-Authors

Yujiro Hayashi
Yujiro Hayashi Tohoku University
Junichiro Yamaguchi
Junichiro Yamaguchi Waseda University
Minoru Yoshida
Minoru Yoshida University of Tokyo
Yoshiharu Iwabuchi
Yoshiharu Iwabuchi Tohoku University
Hiroyuki Koshino
Hiroyuki Koshino Tokyo University of Agriculture
Shinya Oishi
Shinya Oishi Kyoto University
Hiromichi Ohta
Hiromichi Ohta Hokkaido University
Kazuo Umezawa
Kazuo Umezawa Aichi Medical University

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