2020 - Distinguished Scientist Award, American Heart Association
Member of the Association of American Physicians
His primary areas of study are Nitric oxide, Nitrite, Internal medicine, Biochemistry and Hemoglobin. His study in Nitric oxide is interdisciplinary in nature, drawing from both Anesthesia, Biophysics, Methemoglobin, Pharmacology and Vasodilation. His Nitrite research is multidisciplinary, relying on both Nitric oxide synthase, Hypoxia and Heme.
He combines subjects such as Endocrinology, Surgery and Cardiology with his study of Internal medicine. His biological study spans a wide range of topics, including Reperfusion injury and Nitrate. His Hemoglobin study also includes fields such as
Mark T. Gladwin mainly investigates Internal medicine, Nitric oxide, Pulmonary hypertension, Nitrite and Hemoglobin. His work carried out in the field of Internal medicine brings together such families of science as Gastroenterology, Endocrinology and Cardiology. The study incorporates disciplines such as Hypoxia, Biochemistry, Endothelial dysfunction, Pharmacology and Vasodilation in addition to Nitric oxide.
His study looks at the relationship between Pulmonary hypertension and fields such as Pathology, as well as how they intersect with chemical problems. The Nitrite study combines topics in areas such as Sodium nitrite, Anesthesia and Reperfusion injury, Ischemia. He has researched Hemoglobin in several fields, including Hemolysis, Biophysics and Red blood cell.
Internal medicine, Disease, Cardiology, Pulmonary hypertension and Cell are his primary areas of study. The concepts of his Internal medicine study are interwoven with issues in Gastroenterology, Endocrinology and Oncology. His research in Disease intersects with topics in Precision medicine, Hemoglobin and Immunology.
Mark T. Gladwin interconnects Cytochrome b5 reductase and Heme in the investigation of issues within Hemoglobin. He studied Cardiology and Nitrite that intersect with Vasodilation. In his study, Biochemistry is inextricably linked to Nitric oxide, which falls within the broad field of Vasodilation.
Mark T. Gladwin spends much of his time researching Internal medicine, Pulmonary hypertension, Hemolysis, Disease and Nitric oxide. His Internal medicine research includes themes of Gastroenterology, Metabolome, Endocrinology and Oncology. His studies deal with areas such as Vascular resistance and Adenosine deaminase as well as Pulmonary hypertension.
Mark T. Gladwin has included themes like Cell, Red blood cell, Complete blood count and In vivo in his Hemolysis study. His work deals with themes such as Endothelial dysfunction, Immunology and Intensive care medicine, which intersect with Disease. His Nitric oxide research is multidisciplinary, incorporating elements of Reactive oxygen species, Hemoglobin, Nitrite and Vasodilation.
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The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Jon O. Lundberg;Eddie Weitzberg;Mark T. Gladwin.
Nature Reviews Drug Discovery (2008)
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby;Kristine S Partovi;Jack H Crawford;Rakesh P Patel.
Nature Medicine (2003)
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.
Russell P. Rother;Leonard Bell;Peter Hillmen;Mark T. Gladwin.
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
Mark T. Gladwin;Vandana Sachdev;Maria L. Jison;Yukitaka Shizukuda.
The New England Journal of Medicine (2004)
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.
Christopher D Reiter;Xunde Wang;Jose E Tanus-Santos;Neil Hogg.
Nature Medicine (2002)
Right Ventricular Function and Failure Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure
Norbert F. Voelkel;Robert A. Quaife;Leslie A. Leinwand;Robyn J. Barst.
Sickle Cell Disease
David C Rees;Thomas N Williams;Thomas N Williams;Mark T Gladwin.
Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes
Gregory J. Kato;Mark T. Gladwin;Martin H. Steinberg.
Blood Reviews (2007)
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
Claudia R. Morris;Gregory J. Kato;Mirjana Poljakovic;Xunde Wang.
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Mark R. Duranski;James J.M. Greer;Andre Dejam;Sathya Jaganmohan.
Journal of Clinical Investigation (2005)
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