D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 121 Citations 56,748 802 World Ranking 2012 National Ranking 1171

Research.com Recognitions

Awards & Achievements

2020 - Distinguished Scientist Award, American Heart Association

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Enzyme

His primary areas of study are Nitric oxide, Nitrite, Internal medicine, Biochemistry and Hemoglobin. His study in Nitric oxide is interdisciplinary in nature, drawing from both Anesthesia, Biophysics, Methemoglobin, Pharmacology and Vasodilation. His Nitrite research is multidisciplinary, relying on both Nitric oxide synthase, Hypoxia and Heme.

He combines subjects such as Endocrinology, Surgery and Cardiology with his study of Internal medicine. His biological study spans a wide range of topics, including Reperfusion injury and Nitrate. His Hemoglobin study also includes fields such as

  • Red blood cell that connect with fields like Blood cell,
  • Hemolysis that connect with fields like Haptoglobin.

His most cited work include:

  • The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics (1662 citations)
  • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. (1455 citations)
  • The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. (1126 citations)

What are the main themes of his work throughout his whole career to date?

Mark T. Gladwin mainly investigates Internal medicine, Nitric oxide, Pulmonary hypertension, Nitrite and Hemoglobin. His work carried out in the field of Internal medicine brings together such families of science as Gastroenterology, Endocrinology and Cardiology. The study incorporates disciplines such as Hypoxia, Biochemistry, Endothelial dysfunction, Pharmacology and Vasodilation in addition to Nitric oxide.

His study looks at the relationship between Pulmonary hypertension and fields such as Pathology, as well as how they intersect with chemical problems. The Nitrite study combines topics in areas such as Sodium nitrite, Anesthesia and Reperfusion injury, Ischemia. He has researched Hemoglobin in several fields, including Hemolysis, Biophysics and Red blood cell.

He most often published in these fields:

  • Internal medicine (41.26%)
  • Nitric oxide (29.25%)
  • Pulmonary hypertension (25.09%)

What were the highlights of his more recent work (between 2017-2021)?

  • Internal medicine (41.26%)
  • Disease (12.13%)
  • Cardiology (16.53%)

In recent papers he was focusing on the following fields of study:

Internal medicine, Disease, Cardiology, Pulmonary hypertension and Cell are his primary areas of study. The concepts of his Internal medicine study are interwoven with issues in Gastroenterology, Endocrinology and Oncology. His research in Disease intersects with topics in Precision medicine, Hemoglobin and Immunology.

Mark T. Gladwin interconnects Cytochrome b5 reductase and Heme in the investigation of issues within Hemoglobin. He studied Cardiology and Nitrite that intersect with Vasodilation. In his study, Biochemistry is inextricably linked to Nitric oxide, which falls within the broad field of Vasodilation.

Between 2017 and 2021, his most popular works were:

  • Sickle Cell Disease (553 citations)
  • Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program (143 citations)
  • Pathophysiology of Sickle Cell Disease. (86 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

Mark T. Gladwin spends much of his time researching Internal medicine, Pulmonary hypertension, Hemolysis, Disease and Nitric oxide. His Internal medicine research includes themes of Gastroenterology, Metabolome, Endocrinology and Oncology. His studies deal with areas such as Vascular resistance and Adenosine deaminase as well as Pulmonary hypertension.

Mark T. Gladwin has included themes like Cell, Red blood cell, Complete blood count and In vivo in his Hemolysis study. His work deals with themes such as Endothelial dysfunction, Immunology and Intensive care medicine, which intersect with Disease. His Nitric oxide research is multidisciplinary, incorporating elements of Reactive oxygen species, Hemoglobin, Nitrite and Vasodilation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

Jon O. Lundberg;Eddie Weitzberg;Mark T. Gladwin.
Nature Reviews Drug Discovery (2008)

2594 Citations

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.

Kenyatta Cosby;Kristine S Partovi;Jack H Crawford;Rakesh P Patel.
Nature Medicine (2003)

1937 Citations

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.

Russell P. Rother;Leonard Bell;Peter Hillmen;Mark T. Gladwin.
JAMA (2005)

1648 Citations

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease

Mark T. Gladwin;Vandana Sachdev;Maria L. Jison;Yukitaka Shizukuda.
The New England Journal of Medicine (2004)

1409 Citations

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.

Christopher D Reiter;Xunde Wang;Jose E Tanus-Santos;Neil Hogg.
Nature Medicine (2002)

1336 Citations

Right Ventricular Function and Failure Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure

Norbert F. Voelkel;Robert A. Quaife;Leslie A. Leinwand;Robyn J. Barst.
Circulation (2006)

1319 Citations

Sickle Cell Disease

David C Rees;Thomas N Williams;Thomas N Williams;Mark T Gladwin.
(2021)

927 Citations

Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes

Gregory J. Kato;Mark T. Gladwin;Martin H. Steinberg.
Blood Reviews (2007)

897 Citations

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.

Claudia R. Morris;Gregory J. Kato;Mirjana Poljakovic;Xunde Wang.
JAMA (2005)

794 Citations

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Mark R. Duranski;James J.M. Greer;Andre Dejam;Sathya Jaganmohan.
Journal of Clinical Investigation (2005)

779 Citations

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