Weihong Song

Best Publications

• Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.

  Jin Xu;Shyan Yuan Kao;Frank J S Lee;Weihong Song

  989
  Citations

• Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

  Xiulian Sun;Guiqiong He;Guiqiong He;Hong Qing;Weihui Zhou

  700
  Citations

• Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

  Kelley Bromley-Brits;Yu Deng;Weihong Song

  636
  Citations

• Presenilins are required for γ -secretase cleavage of β -APP and transmembrane cleavage of Notch-1

  Zhuohua Zhang;Philip Nadeau;Weihong Song;Dorit Donoviel

  537
  Citations

• Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.

  Weihong Song;Philip Nadeau;Menglan Yuan;Xudong Yang

  517
  Citations

• Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

  Chia-Hsiung Chen;Weihui Zhou;Shengchun Liu;Yu Deng

  479
  Citations

• Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

  Philip T.T. Ly;Yili Wu;Haiyan Zou;Ruitao Wang

  466
  Citations

• Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

  Hong Qing;Guiqiong He;Philip T. T. Ly;Christopher J. Fox

  434
  Citations

• Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

  Michelle A. Christensen;Weihui Zhou;Hong Qing;Anna Lehman

  275
  Citations

• Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease.

  Yang Xiang;Xian‑Le Bu;Yu‑Hui Liu;Chi Zhu

  269
  Citations

• Oxidative stress potentiates BACE1 gene expression and Aβ generation

  Y. Tong;W. Zhou;V. Fung;M. A. Christensen

  269
  Citations

• Molecular links between Alzheimer’s disease and diabetes mellitus

  Y. Yang;W. Song

  245
  Citations

• Blood-derived amyloid-β protein induces Alzheimer's disease pathologies

  Bu Xl;Xiang Y;Jin Ws;Wang J

  241
  Citations

• Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis

  Zhifang Dong;Huili Han;Hongjie Li;Yanrui Bai

  227
  Citations

• The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

  Xiaojie Zhang;Weihong Song

  221
  Citations

• BACE2, as a novel APP θ-secretase, is not responsible for the pathogenesis of Alzheimer’s disease in Down syndrome

  Xiulian Sun;Guiqiong He;Guiqiong He;Weihong Song

  200
  Citations

• Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.

  Xin Wang;Xuan Zhou;Gongying Li;Yun Zhang

  170
  Citations

• Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

  Xiulian Sun;Yingcheng Wang;Yingcheng Wang;Hong Qing;Michelle A. Christensen

  169
  Citations

• Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

  Heng Liu;Pin Wang;Weihong Song;Xiulian Sun

  161
  Citations

• Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

  Mingming Zhang;Fang Cai;Shuting Zhang;Si Zhang

  158
  Citations

• Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation

  Xiu Lian Sun;Yi Li Wu;Bin Chen;Zhuohua Zhang

  138
  Citations