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Genetics

D-Index
58
Citations
39940
World Ranking
3281
National Ranking
1428

Research.com Recognitions

  • 2010 - National Institutes of Health Director's Pioneer Award
  • 2002 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

Overview

Bruce A. Yankner is affiliated with Harvard University in the United States. Their research output spans diverse topics primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. The focus areas include Molecular Biology, Aging, Physiology, Genetics, and Neurology.

The scientist's work covers several main research themes, including:

  • Single-cell and spatial transcriptomics
  • Genetics, Aging, and Longevity in Model Organisms
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Tryptophan and brain disorders

Recent published papers by Bruce A. Yankner include:

  • The adaptive aging brain (2021), published in Current Opinion in Neurobiology
  • Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses (2021), published in Nucleic Acids Research
  • Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression (2022), published in Science Advances
  • Lithium deficiency and the onset of Alzheimer's disease (2025), published in Nature
  • Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder (2022), published in Nature Communications

Frequent coauthors with Bruce A. Yankner include:

  • Liviu Aron
  • George M. Church
  • Derek Drake
  • Katharina Meyer
  • Jaejoon Choi

Common publication venues for Yankner's work include:

  • Nature Communications
  • Current Opinion in Neurobiology
  • Nucleic Acids Research
  • Science Advances
  • Nature

Bruce A. Yankner has received several awards, including the National Institutes of Health Director's Pioneer Award in 2010 and the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2002.

Best Publications

  • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.

    Toshiyuki Nakagawa;Hong Zhu;Nobuhiro Morishima;En Li

  • Apoptosis in the nervous system

    Junying Yuan;Bruce A. Yankner

  • Gene regulation and DNA damage in the ageing human brain.

    Tao Lu;Ying Pan;Shyan Yuan Kao;Cheng Li

  • Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

    Bruce A. Yankner;Linda R. Dawes;Shannon Fisher;Lydia Villa-Komaroff

  • APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

    Yuan-Ta Lin;Jinsoo Seo;Jinsoo Seo;Fan Gao;Heather M. Feldman

  • Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

    Alfredo Lorenzo;Bronwyn Razzaboni;Gordon C. Weir;Bruce A. Yankner

  • Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.

    Jin Xu;Shyan Yuan Kao;Frank J S Lee;Weihong Song

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

  • The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

    Chanhee Kang;Qikai Xu;Timothy D Martin;Mamie Z Li

  • Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

    Jorge Busciglio;Dana H. Gabuzda;Paul Matsudaira;Bruce A. Yankner

  • REST and stress resistance in ageing and Alzheimer’s disease

    Tao Lu;Liviu Aron;Joseph Zullo;Ying Pan

  • Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis

    Zhuohua Zhang;H. Hartmann;Viet Minh Do;D. Abramowski

  • Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

    Marta M. Lipinski;Bin Zheng;Tao Lu;Zhenyu Yan

  • beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

    Unknown

  • The Aging Stress Response

    Marcia C. Haigis;Bruce A. Yankner

  • Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

    Sofia Papadia;Francesc X Soriano;Frédéric Léveillé;Marc-Andre Martel

  • Presenilins are required for γ -secretase cleavage of β -APP and transmembrane cleavage of Notch-1

    Zhuohua Zhang;Philip Nadeau;Weihong Song;Dorit Donoviel

  • β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

    Chunming Liu;Yoichi Kato;Zhuohua Zhang;Viet Minh Do

  • Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

    Mamoru Shibata;Tao Lu;Tsuyoshi Furuya;Alexei Degterev

  • Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.

    Weihong Song;Philip Nadeau;Menglan Yuan;Xudong Yang

Frequent Co-Authors

Junying Yuan
Junying Yuan Harvard University
George M. Church
George M. Church Harvard University
Rachael L. Neve
Rachael L. Neve Harvard University
Dana Gabuzda
Dana Gabuzda Harvard University
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Paolo Paganetti
Paolo Paganetti Universita della Svizzera Italiana
Eric M. Shooter
Eric M. Shooter Stanford University
Weihong Song
Weihong Song University of British Columbia
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital

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