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Chemistry

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Research.com Recognitions

  • 1971 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Randolph V. Lewis is affiliated with Utah State University in the United States. Their primary research spans Materials Science and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on biomaterials and molecular biology subfields.

The scientist's work largely focuses on silk-based biomaterials and applications, covering topics related to biochemical and structural characterization, animal genetics and reproduction, advanced materials and mechanics, electrospun nanofibers in biomedical applications, antimicrobial peptides and activities, and developmental biology and gene regulation.

Lewis has published in various scientific venues, with multiple contributions to Macromolecular Materials and Engineering, Protein Expression and Purification, Microbial Biotechnology, and ACS Omega. Key publications include:

  • Large scale production of synthetic spider silk proteins in Escherichia coli, 2021, Protein Expression and Purification
  • The next generation of protein super-fibres: robust recombinant production and recovery of hagfish intermediate filament proteins with fibre spinning and mechanical-structural characterizations, 2021, Microbial Biotechnology
  • Molecular Dynamics of Synthetic Flagelliform Silk Fiber Assembly, 2020, Macromolecular Materials and Engineering
  • Scalable purification of recombinant structural proteins, hagfish intermediate filament α and ɣ, from inclusion bodies for fiber formation, 2022, Protein Expression and Purification
  • Molecular Dynamics of Synthetic Flagelliform Silk Fiber Assembly, 2021, Macromolecular Materials and Engineering

The scientist frequently collaborates with colleagues in their field. Frequent co-authors include Paula F. Oliveira, Brianne E. Bell, Justin A. Jones, Dong Chen, and Thomas I. Harris.

Among their recognitions, Randolph V. Lewis was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 1971.

Best Publications

  • Structure of a protein superfiber: spider dragline silk.

    Ming Xu;Randolph V. Lewis

  • Hypotheses that correlate the sequence, structure, and mechanical properties of spider silk proteins.

    Cheryl Y. Hayashi;Nichola H. Shipley;Randolph V. Lewis

  • Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber.

    M B Hinman;R V Lewis

  • Extreme Diversity, Conservation, and Convergence of Spider Silk Fibroin Sequences

    John Gatesy;Cheryl Hayashi;Dagmara Motriuk;Justin Woods

  • Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins

    H Mach;C R Middaugh;R V Lewis

  • Spider silk: ancient ideas for new biomaterials.

    Randolph V. Lewis

  • Evidence from flagelliform silk cDNA for the structural basis of elasticity and modular nature of spider silks

    Cheryl Y Hayashi;Randolph V Lewis

  • Synthetic spider silk: a modular fiber

    Michael B Hinman;Justin A Jones;Randolph V Lewis

  • Molecular Architecture and Evolution of a Modular Spider Silk Protein Gene

    Cheryl Y. Hayashi;Randolph V. Lewis

  • Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.

    Alvin S. Stern;Randolph V. Lewis;Sadao Kimura;Jean Rossier

  • An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.

    Randolph V. Lewis;Alvin S. Stern;Sadao Kimura;Jean Rossier

  • Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties

    Florence Teulé;Yun-Gen Miao;Bong-Hee Sohn;Young-Soo Kim

  • Molecular and Mechanical Characterization of Aciniform Silk: Uniformity of Iterated Sequence Modules in a Novel Member of the Spider Silk Fibroin Gene Family

    Cheryl Y. Hayashi;Todd A. Blackledge;Randolph V. Lewis

  • Expression and purification of a spider silk protein: a new strategy for producing repetitive proteins.

    Randolph V. Lewis;Michael Hinman;Srinivas Kothakota;Maurille J. Fournier

  • Putative enkephalin precursors in bovine adrenal medulla

    R.V. Lewis;A.S. Stern;J. Rossier;S. Stein

  • A protocol for the production of recombinant spider silk-like proteins for artificial fiber spinning

    Florence Teulé;Alyssa R Cooper;William A Furin;Daniela Bittencourt

  • Spider minor ampullate silk proteins contain new repetitive sequences and highly conserved non‐silk‐like “spacer regions”

    Mark A. Colgin;Randolph V. Lewis

  • Structural studies of spider silk proteins in the fiber

    Ajay D. Parkhe;Stacy K. Seeley;Kenneth Gardner;Lynmarie Thompson

  • Supports for reverse-phase high-performance liquid chromatography of large proteins

    Randolph V. Lewis;Anthony Fallon;Stanley Stein;Kenneth D. Gibson

  • SPIDER SILK : THE UNRAVELING OF A MYSTERY

    Randolph V. Lewis

Frequent Co-Authors

Sidney Udenfriend
Sidney Udenfriend Roche Institute of Molecular Biology
Stanley Stein
Stanley Stein Rutgers, The State University of New Jersey
Jeffery L. Yarger
Jeffery L. Yarger Arizona State University
Cheryl Y. Hayashi
Cheryl Y. Hayashi American Museum of Natural History
Sadao Kimura
Sadao Kimura Chiba University
C. Russell Middaugh
C. Russell Middaugh University of Kansas
Jean Rossier
Jean Rossier Sorbonne University
John E. Shively
John E. Shively City Of Hope National Medical Center
Igor Krupa
Igor Krupa Qatar University
Chris J. Benmore
Chris J. Benmore Argonne National Laboratory

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