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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
20464
World Ranking
5581
National Ranking
205

Overview

Neil R. Cashman is a researcher affiliated with the University of British Columbia in Canada. Their primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Within these broad disciplines, Cashman's work focuses on subfields such as Molecular Biology, Neurology, Physiology, Genetics, and Computational Theory and Mathematics.

Cashman's research covers several main topics, notably Amyotrophic Lateral Sclerosis Research, Alzheimer's disease research and treatments, Prion Diseases and Protein Misfolding, Neurogenetic and Muscular Disorders Research, Parkinson's Disease Mechanisms and Treatments, Computational Drug Discovery Methods, and Cholinesterase and Neurodegenerative Diseases.

Their recent publications include:

  • Passive immunotherapies targeting Aβ and tau in Alzheimer's disease, 2020, Neurobiology of Disease
  • Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases, 2020, iScience
  • Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises, 2020, Frontiers in Cellular Neuroscience
  • Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection, 2020, PLoS ONE
  • Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E, 2020, Molecular Neurodegeneration

Frequent co-authors collaborating with Cashman include Steven S. Plotkin, Ebrima Gibbs, Johanne Kaplan, Luke McAlary, and Beibei Zhao.

Cashman's work has been published largely in venues related to neurology and biomedicine. Notable recurring publication venues are Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Neurology, PLoS ONE, and the Journal of Biological Chemistry.

The combination of Cashman's research areas and consistent publication in high-impact journals reflects a focus on neurodegenerative diseases and associated molecular mechanisms, with a notable interest in protein misfolding disorders and neurogenetic conditions.

Best Publications

  • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

    B. Oosthuyse;L. Moons;E. Storkebaum;H. Beck

  • Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons.

    Neil R. Cashman;Heather D. Durham;Jan Krzysztof Blusztajn;Kenichiro Oda

  • Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels

    Jeanne S. Teitelbaum;Robert J. Zatorre;Stirling Carpenter;Daniel Gendron

  • Iatrogenic Creutzfeldt-Jakob disease at the millennium.

    P. Brown;M. Preece;J.-P. Brandel;T. Sato

  • Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.

    Nicola J. Rutherford;Yong-Jie Zhang;Matt Baker;Jennifer M Gass

  • Nearly ubiquitous tissue distribution of the scrapie agent precursor protein.

    P. E. Bendheim;H. R. Brown;R. D. Rudelli;L. J. Scala

  • Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

    Sameer D. D'Souza;Bruno Bonetti;Vijayabalan Balasingam;Neil R. Cashman

  • Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.

    Leslie I Grad;Justin J Yerbury;Bradley J Turner;William C Guest

  • Cellular isoform of the scrapie agent protein participates in lymphocyte activation.

    Neil R. Cashman;Rolf Loertscher;Josephine Nalbantoglu;Ivan Shaw

  • Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis.

    Rishi Rakhit;Patricia Cunningham;Alexandra Furtos-Matei;Sophie Dahan

  • Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis

    Rishi Rakhit;John P. Crow;James R. Lepock;Leslie H. Kondejewski

  • A prion protein epitope selective for the pathologically misfolded conformation

    Eustache Paramithiotis;Marc Pinard;Trebor Lawton;Sylvie LaBoissiere

  • Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

    Christine Vande Velde;Timothy M. Miller;Neil R. Cashman;Don W. Cleveland

  • Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

    Leslie I. Grad;Will C. Guest;Anat Yanai;Edward Pokrishevsky

  • Post-poliomyelitis syndrome.

    Daria A. Trojan;Neil R. Cashman

  • An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS

    Rishi Rakhit;Janice Robertson;Christine Vande Velde;Patrick Horne

  • Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.

    Lisa M. Ellerby;Abigail S. Hackam;Stephanie S. Propp;H. Michael Ellerby

  • Temporal lobe epilepsy caused by domoic acid intoxication: Evidence for glutamate receptor–mediated excitotoxicity in humans

    Fernando Cendes;Frcp Frederick Andermann Md;Stirling Carpenter;Robert J. Zatorre

  • Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo.

    Voon Wee Yong;Robert Moumdjian;Fiona P. Yong;Theodora C. G. Ruijs

  • Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

    H M Ellerby;S J Martin;L M Ellerby;S S Naiem;S S Naiem

Frequent Co-Authors

Justin J. Yerbury
Justin J. Yerbury University of Wollongong
Jack P. Antel
Jack P. Antel McGill University
Daniel Krewski
Daniel Krewski University of Ottawa
Ian R. Mackenzie
Ian R. Mackenzie University of British Columbia
David S. Wishart
David S. Wishart University of Alberta
Douglas L. Arnold
Douglas L. Arnold Montreal Neurological Institute and Hospital
Avijit Chakrabartty
Avijit Chakrabartty University of Toronto
David Westaway
David Westaway University of Alberta
Marco A. M. Prado
Marco A. M. Prado University of Western Ontario
Philip J. Griebel
Philip J. Griebel University of Saskatchewan

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