World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
105
Citations
37865
World Ranking
1012
National Ranking
401

Biology and Biochemistry

D-Index
101
Citations
34938
World Ranking
1455
National Ranking
827

Overview

Ernest Hamel is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on chemistry, with a significant emphasis on organic chemistry. The subfields of study that characterize their work include organic chemistry, materials chemistry, molecular biology, pharmacology, and toxicology.

The main topics addressed in their publications cover a range of subjects related to chemical synthesis, biological evaluation, and structural studies. These topics include:

  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Click Chemistry and Applications
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and Reactions of Organic Compounds

Ernest Hamel has contributed notably to the literature in medicinal chemistry and pharmacology with research papers published in several respected journals. Recent publications include:

  • Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development, 2021, Pharmacology & Therapeutics
  • Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types, 2020, Journal of Medicinal Chemistry
  • Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas, 2022, European Journal of Medicinal Chemistry
  • Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry
  • Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry

Frequent publication venues for Hamel's work include:

  • The Cambridge Structural Database
  • European Journal of Medicinal Chemistry
  • UNC Libraries
  • Bioorganic & Medicinal Chemistry
  • Journal of Medicinal Chemistry

The scientist has collaborated repeatedly with a group of coauthors, among whom frequent collaborators are:

  • Ruoli Bai
  • Éva A. Enyedy
  • Jóhannes Reynisson
  • Vladimir B. Arion
  • Giampietro Viola

Best Publications

  • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    George Pettit;S. B. Singh;E. Hamel;C. M. Lin

  • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

    Nancy Klauber;Sareh Parangi;Evelyn Flynn;Ernest Hamel

  • Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

    Richard J. Kowalski;Paraskevi Giannakakou;Ernest Hamel

  • Synthesis of epothilones A and B in solid and solution phase

    K. C. Nicolaou;Nicolas Charles Winssinger;Nicolas Charles Winssinger;J. Pastor;J. Pastor;S. Ninkovic;S. Ninkovic

  • Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

    Chii M. Lin;Holly H. Ho;George R. Pettit;Ernest Hamel

  • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

    E. Ten Haar;R. J. Kowalski;E. Hamel;C. M. Lin

  • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site

    Robert J. D'Amato;Chii M. Lin;Evelyn Flynn;Judah Folkman

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

    William H. Gerwick;Philip J. Proteau;Dale G. Nagle;Ernest Hamel

  • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

    Ruoli Bai;Kenneth D. Paull;Cherry L. Herald;Louis Malspeis

  • Antimitotic natural products and their interactions with tubulin

    Ernest Hamel

  • Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

    George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel

  • New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

    Gabriella De Martino;Michael C. Edler;Giuseppe La Regina;Antonio Coluccia

  • Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

    Mark Cushman;Dhanapalan Nagarathnam;D. Gopal;Asit K. Chakraborti

  • Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

    C M Lin;S B Singh;P S Chu;R O Dempcy

  • Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

    Ruoli Bai;George Pettit;Ernest Hamel

  • Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

    Pascal Verdier-Pinard;Jing Yu Lai;Hae Dong Yoo;Jurong Yu

  • Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization

    Jack B. Jiang;D. P. Hesson;B. A. Dusak;D. L. Dexter

  • Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.

    Ernest Hamel

  • Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

    R L Bai;G R Pettit;E Hamel

Frequent Co-Authors

Romeo Romagnoli
Romeo Romagnoli University of Ferrara
George R. Pettit
George R. Pettit Arizona State University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Pier Giovanni Baraldi
Pier Giovanni Baraldi University of Ferrara
Giuseppe Basso
Giuseppe Basso University of Padua
Jan Balzarini
Jan Balzarini KU Leuven
Romano Silvestri
Romano Silvestri Sapienza University of Rome
Mark Cushman
Mark Cushman Purdue University West Lafayette
Martin G. Banwell
Martin G. Banwell Australian National University

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