World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
34938
World Ranking
1455
National Ranking
827

Chemistry

D-Index
105
Citations
37865
World Ranking
1012
National Ranking
400

Ernest Hamel publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Ernest Hamel sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 503 publications — 89th percentile

89% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Ernest Hamel D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Ernest Hamel sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 105 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Ernest Hamel is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on chemistry, with a significant emphasis on organic chemistry. The subfields of study that characterize their work include organic chemistry, materials chemistry, molecular biology, pharmacology, and toxicology.

The main topics addressed in their publications cover a range of subjects related to chemical synthesis, biological evaluation, and structural studies. These topics include:

  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Click Chemistry and Applications
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and Reactions of Organic Compounds

Ernest Hamel has contributed notably to the literature in medicinal chemistry and pharmacology with research papers published in several respected journals. Recent publications include:

  • Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development, 2021, Pharmacology & Therapeutics
  • Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types, 2020, Journal of Medicinal Chemistry
  • Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas, 2022, European Journal of Medicinal Chemistry
  • Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry
  • Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry

Frequent publication venues for Hamel's work include:

  • The Cambridge Structural Database
  • European Journal of Medicinal Chemistry
  • UNC Libraries
  • Bioorganic & Medicinal Chemistry
  • Journal of Medicinal Chemistry

The scientist has collaborated repeatedly with a group of coauthors, among whom frequent collaborators are:

  • Ruoli Bai
  • Éva A. Enyedy
  • Jóhannes Reynisson
  • Vladimir B. Arion
  • Giampietro Viola

Best Publications

  • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    George Pettit;S. B. Singh;E. Hamel;C. M. Lin

  • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

    Nancy Klauber;Sareh Parangi;Evelyn Flynn;Ernest Hamel

  • Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

    Richard J. Kowalski;Paraskevi Giannakakou;Ernest Hamel

  • Synthesis of epothilones A and B in solid and solution phase

    K. C. Nicolaou;Nicolas Charles Winssinger;Nicolas Charles Winssinger;J. Pastor;J. Pastor;S. Ninkovic;S. Ninkovic

  • Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

    Chii M. Lin;Holly H. Ho;George R. Pettit;Ernest Hamel

  • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

    E. Ten Haar;R. J. Kowalski;E. Hamel;C. M. Lin

  • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site

    Robert J. D'Amato;Chii M. Lin;Evelyn Flynn;Judah Folkman

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

    William H. Gerwick;Philip J. Proteau;Dale G. Nagle;Ernest Hamel

  • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

    Ruoli Bai;Kenneth D. Paull;Cherry L. Herald;Louis Malspeis

  • Antimitotic natural products and their interactions with tubulin

    Ernest Hamel

  • Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

    George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel

  • New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

    Gabriella De Martino;Michael C. Edler;Giuseppe La Regina;Antonio Coluccia

  • Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

    Mark Cushman;Dhanapalan Nagarathnam;D. Gopal;Asit K. Chakraborti

  • Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

    C M Lin;S B Singh;P S Chu;R O Dempcy

  • Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

    Ruoli Bai;George Pettit;Ernest Hamel

  • Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

    Pascal Verdier-Pinard;Jing Yu Lai;Hae Dong Yoo;Jurong Yu

  • Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization

    Jack B. Jiang;D. P. Hesson;B. A. Dusak;D. L. Dexter

  • Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.

    Ernest Hamel

  • Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

    R L Bai;G R Pettit;E Hamel

Frequent Co-Authors

Romeo Romagnoli
Romeo Romagnoli University of Ferrara
George R. Pettit
George R. Pettit Arizona State University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Pier Giovanni Baraldi
Pier Giovanni Baraldi University of Ferrara
Giuseppe Basso
Giuseppe Basso University of Padua
Jan Balzarini
Jan Balzarini KU Leuven
Romano Silvestri
Romano Silvestri Sapienza University of Rome
Mark Cushman
Mark Cushman Purdue University West Lafayette
Martin G. Banwell
Martin G. Banwell Australian National University

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