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Ernest Hamel

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 105 1012 891 400 322 503 37865
Biology and Biochemistry 101 1454 1308 826 727 435 34938

Ernest Hamel publications per year

The chart shows the history of publications by Ernest Hamel between 1968 and 2026, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Ernest Hamel published across 59 years, from 1968 to 2026, averaging 9.5 papers a year. Output peaked at 45 publications in 2023. 5 of the 560 publications appeared in the last two years.

No. of publications
10 20 30 40
Bar chart. Horizontal axis: year, 1968 to 2026. Vertical axis: number of publications, 0 to 45. Peak 45 publications in 2023. 1968: 1 publication 1969: 0 publications 1970: 0 publications 1971: 0 publications 1972: 3 publications 1973: 1 publication 1974: 1 publication 1975: 2 publications 1976: 2 publications 1977: 0 publications 1978: 0 publications 1979: 0 publications 1980: 0 publications 1981: 6 publications 1982: 3 publications 1983: 3 publications 1984: 4 publications 1985: 4 publications 1986: 8 publications 1987: 5 publications 1988: 8 publications 1989: 6 publications 1990: 9 publications 1991: 7 publications 1992: 11 publications 1993: 15 publications 1994: 16 publications 1995: 14 publications 1996: 8 publications 1997: 18 publications 1998: 15 publications 1999: 17 publications 2000: 13 publications 2001: 7 publications 2002: 14 publications 2003: 9 publications 2004: 10 publications 2005: 18 publications 2006: 12 publications 2007: 12 publications 2008: 15 publications 2009: 18 publications 2010: 15 publications 2011: 15 publications 2012: 21 publications 2013: 21 publications 2014: 21 publications 2015: 13 publications 2016: 9 publications 2017: 10 publications 2018: 12 publications 2019: 13 publications 2020: 14 publications 2021: 10 publications 2022: 12 publications 2023: 45 publications 2024: 9 publications 2025: 4 publications 2026: 1 publication
1968 2026

560 publications in total across all disciplines

View publications per year as a table
Ernest Hamel: publications per year, 1968 to 2026
Year Publications
1968 1
1969 0
1970 0
1971 0
1972 3
1973 1
1974 1
1975 2
1976 2
1977 0
1978 0
1979 0
1980 0
1981 6
1982 3
1983 3
1984 4
1985 4
1986 8
1987 5
1988 8
1989 6
1990 9
1991 7
1992 11
1993 15
1994 16
1995 14
1996 8
1997 18
1998 15
1999 17
2000 13
2001 7
2002 14
2003 9
2004 10
2005 18
2006 12
2007 12
2008 15
2009 18
2010 15
2011 15
2012 21
2013 21
2014 21
2015 13
2016 9
2017 10
2018 12
2019 13
2020 14
2021 10
2022 12
2023 45
2024 9
2025 4
2026 1
Total 560
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Ernest Hamel publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Ernest Hamel sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 501–520 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 503 publications — 89th percentile

89% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623
121–140 918
141–160 1,218
161–180 1,350
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270
461–480 265
481–500 252
501–520 201 503
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Ernest Hamel D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Ernest Hamel sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 104–105 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 105 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289
42–43 612
44–45 808
46–47 776
48–49 835
50–51 861
52–53 872
54–55 933
56–57 1,051
58–59 930
60–61 882
62–63 834
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112 105
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
Download as CSV

Overview

Ernest Hamel is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on chemistry, with a significant emphasis on organic chemistry. The subfields of study that characterize their work include organic chemistry, materials chemistry, molecular biology, pharmacology, and toxicology.

The main topics addressed in their publications cover a range of subjects related to chemical synthesis, biological evaluation, and structural studies. These topics include:

  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Click Chemistry and Applications
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and Reactions of Organic Compounds

Ernest Hamel has contributed notably to the literature in medicinal chemistry and pharmacology with research papers published in several respected journals. Recent publications include:

  • Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development, 2021, Pharmacology & Therapeutics
  • Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types, 2020, Journal of Medicinal Chemistry
  • Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas, 2022, European Journal of Medicinal Chemistry
  • Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry
  • Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, 2020, European Journal of Medicinal Chemistry

Frequent publication venues for Hamel's work include:

  • The Cambridge Structural Database
  • European Journal of Medicinal Chemistry
  • UNC Libraries
  • Bioorganic & Medicinal Chemistry
  • Journal of Medicinal Chemistry

The scientist has collaborated repeatedly with a group of coauthors, among whom frequent collaborators are:

  • Ruoli Bai
  • Éva A. Enyedy
  • Jóhannes Reynisson
  • Vladimir B. Arion
  • Giampietro Viola

Best Publications

  • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    George Pettit;S. B. Singh;E. Hamel;C. M. Lin

  • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

    Nancy Klauber;Sareh Parangi;Evelyn Flynn;Ernest Hamel

  • Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

    Richard J. Kowalski;Paraskevi Giannakakou;Ernest Hamel

  • Synthesis of epothilones A and B in solid and solution phase

    K. C. Nicolaou;Nicolas Charles Winssinger;Nicolas Charles Winssinger;J. Pastor;J. Pastor;S. Ninkovic;S. Ninkovic

  • Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

    Chii M. Lin;Holly H. Ho;George R. Pettit;Ernest Hamel

  • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

    E. Ten Haar;R. J. Kowalski;E. Hamel;C. M. Lin

  • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site

    Robert J. D'Amato;Chii M. Lin;Evelyn Flynn;Judah Folkman

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

    William H. Gerwick;Philip J. Proteau;Dale G. Nagle;Ernest Hamel

  • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

    Ruoli Bai;Kenneth D. Paull;Cherry L. Herald;Louis Malspeis

  • Antimitotic natural products and their interactions with tubulin

    Ernest Hamel

  • Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

    George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel

  • New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

    Gabriella De Martino;Michael C. Edler;Giuseppe La Regina;Antonio Coluccia

  • Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

    Mark Cushman;Dhanapalan Nagarathnam;D. Gopal;Asit K. Chakraborti

  • Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

    C M Lin;S B Singh;P S Chu;R O Dempcy

  • Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

    Ruoli Bai;George Pettit;Ernest Hamel

  • Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

    Pascal Verdier-Pinard;Jing Yu Lai;Hae Dong Yoo;Jurong Yu

  • Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization

    Jack B. Jiang;D. P. Hesson;B. A. Dusak;D. L. Dexter

  • Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.

    Ernest Hamel

  • Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

    R L Bai;G R Pettit;E Hamel

Frequent Co-Authors

Romeo Romagnoli
Romeo Romagnoli University of Ferrara
George R. Pettit
George R. Pettit Arizona State University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Pier Giovanni Baraldi
Pier Giovanni Baraldi University of Ferrara
Giuseppe Basso
Giuseppe Basso University of Padua
Jan Balzarini
Jan Balzarini KU Leuven
Romano Silvestri
Romano Silvestri Sapienza University of Rome
Mark Cushman
Mark Cushman Purdue University West Lafayette
Martin G. Banwell
Martin G. Banwell Australian National University
David G. I. Kingston
David G. I. Kingston Virginia Tech

External Links

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Best Scientists Citing Ernest Hamel

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Kuo Hsiung Lee

University of Minnesota

Publications: 87

William H. Gerwick

William H. Gerwick

University of California, San Diego

Publications: 81

George R. Pettit

George R. Pettit

Arizona State University

Publications: 71

K. C. Nicolaou

K. C. Nicolaou

Rice University

Publications: 65

Ian Paterson

Ian Paterson

University of Cambridge

Publications: 53

David G. I. Kingston

David G. I. Kingston

Virginia Tech

Publications: 51

Sheng-Chu Kuo

Sheng-Chu Kuo

China Medical University

Publications: 49

Karl-Heinz Altmann

Karl-Heinz Altmann

ETH Zurich

Publications: 49

Amos B. Smith

Amos B. Smith

University of Pennsylvania

Publications: 45

Barry V. L. Potter

Barry V. L. Potter

University of Oxford

Publications: 43

Hai-Liang Zhu

Hai-Liang Zhu

Nanjing University

Publications: 42

Dulal Panda

Dulal Panda

Indian Institute of Technology Bombay

Publications: 41

Susan Band Horwitz

Susan Band Horwitz

Albert Einstein College of Medicine

Publications: 39

Jang Yang Chang

Jang Yang Chang

National Health Research Institutes

Publications: 38

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José Manuel Andreu

Spanish National Research Council

Publications: 36

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University of Michigan–Ann Arbor

Publications: 32

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