World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
106
Citations
52331
World Ranking
626
National Ranking
353

Biology and Biochemistry

D-Index
106
Citations
52310
World Ranking
1134
National Ranking
676

Overview

Dale E. Bredesen is affiliated with the University of California, Los Angeles in the United States. Their research primarily focuses on fields within medicine, with specific attention to physiology, psychiatry and mental health, pharmacology, neurology, and computational theory and mathematics.

The scientist's work covers several main topics including:

  • Alzheimer's disease research and treatments
  • Dementia and cognitive impairment research
  • Cholinesterase and neurodegenerative diseases
  • Computational drug discovery methods
  • Neurological disorders and treatments
  • Diet and metabolism studies
  • Medicinal plants and neuroprotection

Among their recent publications are the following papers:

  • Neuroprotective Herbs for the Management of Alzheimer's Disease, 2021, Biomolecules
  • Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review, 2023, International Journal of Molecular Sciences
  • Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project, 2022, Journal of Alzheimer s Disease
  • Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?, 2023, American Journal of Clinical Nutrition
  • ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline, 2021, Biomedicines

Frequent co-authors in their publications include:

  • Cyrus A. Raji
  • Alan Boyd
  • Julie Gregory
  • Rammohan V. Rao
  • Kat Toups

Their work has been published repeatedly in several venues, including:

  • Journal of Alzheimer s Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biomedicines
  • Preprints.org
  • Biomolecules

Dale E. Bredesen's research contributions span multiple interconnected disciplines related to neurodegenerative conditions, with a particular emphasis on Alzheimer's disease. The scientist employs approaches that include multi-factorial therapeutic programs and precision medicine strategies to address cognitive decline. Their interdisciplinary studies integrate elements of diet, metabolism, and medicinal plants as potential modifiers of disease progression.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Bcl-2 inhibition of neural death : decreased generation of reactive oxygen species

    Darci J. Kane;Theodore A. Sarafian;Rein Anton;Hejin Hahn

  • Bax directly induces release of cytochrome c from isolated mitochondria

    Juliane M. Jürgensmeier;Zhihua Xie;Quinn Deveraux;Lisa Ellerby

  • Coupling endoplasmic reticulum stress to the cell death program.

    R V Rao;H M Ellerby;D E Bredesen;D E Bredesen

  • Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature

    Robert M. Levy;Dale E. Bredesen;Mark L. Rosenblum

  • An alternative, nonapoptotic form of programmed cell death

    Sabina Sperandio;Ian de Belle;Dale E. Bredesen

  • Anti-cancer activity of targeted pro-apoptotic peptides

    H. Michael Ellerby;H. Michael Ellerby;Wadih Arap;Lisa M. Ellerby;Lisa M. Ellerby;Renate Kain;Renate Kain

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

    Patricia Spilman;Natalia Podlutskaya;Matthew J. Hart;Jayanta Debnath

  • Induction of Apoptosis by the Low-Affinity NGF Receptor

    Shahrooz Rabizadeh;Justin Oh;Li-tao Zhong;Jie Yang

  • Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

    Henning R. Stennicke;Juliane M. Jürgensmeier;Hwain Shin;Quinn Deveraux

  • Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

    Martina Wiedau-Pazos;Joy J. Goto;Shahrooz Rabizadeh;Edith B. Gralla

  • Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

    Inna Kruman;Annadora J. Bruce-Keller;Dale Bredesen;Georg Waeg

  • Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *

    Veronika Stoka;Veronika Stoka;Boris Turk;Sharon L. Schendel;Tae Hyoung Kim

  • Cell death in the nervous system

    Dale E. Bredesen;Rammohan V. Rao;Patrick Mehlen;Patrick Mehlen

  • Coupling Endoplasmic Reticulum Stress to the Cell Death Program MECHANISM OF CASPASE ACTIVATION

    Rammohan V. Rao;Evan Hermel;Susana Castro-Obregon;Gabriel del Rio

  • bcl-2 inhibits death of central neural cells induced by multiple agents.

    Li-Tao Zhong;Theodore Sarafian;Darci J. Kane;Andrew C. Charles

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

    Rammohan V. Rao;Alyson Peel;Anna Logvinova;Gabriel del Rio

  • Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

    Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

Frequent Co-Authors

Veronica Galvan
Veronica Galvan University of Oklahoma Health Sciences Center
Lisa M. Ellerby
Lisa M. Ellerby Buck Institute for Research on Aging
Patrick Mehlen
Patrick Mehlen UniCancer Group
Edward H. Koo
Edward H. Koo University of California, San Diego
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
Mark L. Rosenblum
Mark L. Rosenblum Henry Ford Health System
Michael R. Hayden
Michael R. Hayden University of British Columbia
John C. Reed
John C. Reed Johnson & Johnson (United States)
Joan Selverstone Valentine
Joan Selverstone Valentine University of California, Los Angeles
Kunlin Jin
Kunlin Jin University of North Texas Health Science Center

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