World's Best Scientists 2026 revealed!
Patrick Mehlen

Patrick Mehlen

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
33349
World Ranking
4215
National Ranking
107

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Patrick Mehlen is affiliated with the UniCancer Group in France. Their research spans several interconnected fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these broad fields, their work delves into Molecular Biology, Cellular and Molecular Neuroscience, Oncology, Developmental Neuroscience, and Epidemiology.

The main topics addressed by Mehlen's research concern Axon Guidance and Neuronal Signaling, Angiogenesis and VEGF in Cancer, Hedgehog Signaling Pathway Studies, Neurogenesis and Neuroplasticity Mechanisms, Developmental Biology and Gene Regulation, Cancer Cells and Metastasis, and HER2/EGFR in Cancer Research.

Mehlen has contributed substantially to the scientific literature, publishing in notable venues. These include:

  • Nature Communications (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • EMBO Molecular Medicine (3 publications)
  • Nature (2 publications)
  • Cell Death and Differentiation (2 publications)

Some of their recent papers, with publication year and venue, are:

  • "Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer," 2023, Nature
  • "Pharmacological targeting of netrin-1 inhibits EMT in cancer," 2023, Nature
  • "Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1," 2021, Nature Communications
  • "Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features," 2020, The EMBO Journal
  • "Dependence receptors: new targets for cancer therapy," 2021, EMBO Molecular Medicine

Patrick Mehlen has collaborated frequently with several researchers, notably:

  • Nicolas Rama (13 collaborations)
  • Benjamin Gibert (12 collaborations)
  • Benjamin Ducarouge (11 collaborations)
  • Nicolas Gadot (8 collaborations)
  • David Neves (6 collaborations)

Among awards, Patrick Mehlen is recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

    Galluzzi L;Vitale I;Vitale I;Vitale I;Abrams Jm;Alnemri Es

  • Metastasis: a question of life or death

    Patrick Mehlen;Alain Puisieux

  • Cell death in the nervous system

    Dale E. Bredesen;Rammohan V. Rao;Patrick Mehlen;Patrick Mehlen

  • Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death

    P Mehlen;C Kretz-Remy;X Préville;A P Arrigo

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Small Stress Proteins as Novel Regulators of Apoptosis HEAT SHOCK PROTEIN 27 BLOCKs FAS/APO-1- AND STAUROSPORINE-INDUCED CELL DEATH

    Patrick Mehlen;Klaus Schulze-Osthoff;André-Patrick Arrigo

  • The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

    Patrick Mehlen;Shahrooz Rabizadeh;Shahrooz Rabizadeh;Scott J. Snipas;Scott J. Snipas;Nuria Assa-Munt;Nuria Assa-Munt

  • Notch Signaling in the Tumor Microenvironment.

    Olivier Meurette;Patrick Mehlen

  • Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

    P Mehlen;X Preville;P Chareyron;J Briolay

  • Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

    Fabien Llambi;Frédéric Causeret;Evelyne Bloch‐Gallego;Patrick Mehlen

  • Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog

    Chantal Thibert;Marie-Aimée Teillet;Françoise Lapointe;Laetitia Mazelin

  • Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

    Laetitia Mazelin;Agnès Bernet;Christelle Bonod-Bidaud;Laurent Pays

  • Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

    C Kretz-Remy;P Mehlen;M E Mirault;A P Arrigo

  • Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

    Christelle Forcet;Elke Stein;Laurent Pays;Véronique Corset

  • HSP27 as a Mediator of Confluence-dependent Resistance to Cell Death Induced by Anticancer Drugs

    Carmen Garrido;Patrick Ottavi;Annie Fromentin;Arlette Hammann

  • The RET proto‐oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

    Marie‐Claire Bordeaux;Christelle Forcet;Laure Granger;Véronique Corset

  • RGM and its receptor neogenin regulate neuronal survival

    Eiji Matsunaga;Servane Tauszig-Delamasure;Philippe P. Monnier;Bernhard K. Mueller

  • hsp27 as a Switch between Differentiation and Apoptosis in Murine Embryonic Stem Cells

    Patrick Mehlen;Anne Mehlen;Jacqueline Godet;André-Patrick Arrigo

  • Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells.

    Patrick Mehlen;Eilen Hickey;Lee A. Weber;André-Patrick Arrigo

Frequent Co-Authors

André-Patrick Arrigo
André-Patrick Arrigo Claude Bernard University Lyon 1
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
Alain Chédotal
Alain Chédotal Institut de la Vision
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Lorenzo Galluzzi
Lorenzo Galluzzi Cornell University
Carmen Garrido
Carmen Garrido University of Burgundy
Ilio Vitale
Ilio Vitale University of Rome Tor Vergata
Jean-Yves Scoazec
Jean-Yves Scoazec Grenoble Alpes University
Sharad Kumar
Sharad Kumar University of Adelaide
Simone Fulda
Simone Fulda Goethe University Frankfurt

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