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Biology and Biochemistry

D-Index
63
Citations
17527
World Ranking
10070
National Ranking
259

Overview

Peter J. van der Spek is affiliated with Erasmus University Rotterdam in the Netherlands. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology. With a significant number of publications, their work contributes extensively to understanding molecular mechanisms underlying various health conditions.

The main fields of study for Peter J. van der Spek include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

The subfields of study they have contributed to encompass:

  • Molecular Biology
  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Immunology
  • Cancer Research

Their research topics cover a variety of areas with the following prominent themes:

  • Immunodeficiency and Autoimmune Disorders
  • Cancer-related molecular mechanisms research
  • Epigenetics and DNA Methylation
  • Heart Failure Treatment and Management
  • Cardiovascular Function and Risk Factors
  • Cytokine Signaling Pathways and Interactions
  • RNA Research and Splicing

The recent papers by Peter J. van der Spek include:

  • Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome (2022), published in Annals of the Rheumatic Diseases
  • Molecular Binding Mechanism and Pharmacology Comparative Analysis of Noscapine for Repurposing against SARS-CoV-2 Protease (2020), published in Journal of Proteome Research
  • A germline STAT6 gain-of-function variant is associated with early-onset allergies (2022), published in Journal of Allergy and Clinical Immunology
  • Precursor lesions of vulvar squamous cell carcinoma - histology and biomarkers: A systematic review (2020), published in Critical Reviews in Oncology/Hematology
  • Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy (2021), published in Human Molecular Genetics

Frequent co-authors collaborating with Peter J. van der Spek are:

  • Sigrid Swagemakers
  • Sigrid M. A. Swagemakers
  • Willem A. Dik
  • Virgil A. S. H. Dalm
  • Janet L. Cunningham

Peter J. van der Spek commonly publishes research in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Allergy and Clinical Immunology
  • Pharmacological Research
  • Genes
  • Human Genetics

Best Publications

  • Prognostically useful gene-expression profiles in acute myeloid leukemia.

    Peter J.M. Valk;Roel G.W. Verhaak;M. Antoinette Beijen;Claudia A.J. Erpelinck

  • Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

    Kaoru Sugasawa;Jessica M.Y Ng;Chikahide Masutani;Shigenori Iwai

  • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

    Monique L Den Boer;Marjon van Slegtenhorst;Renée X De Menezes;Renée X De Menezes;Meyling H Cheok

  • Gene expression-based classification of non-small cell lung carcinomas and survival prediction.

    Jun Hou;Joachim Aerts;Bianca den Hamer;Wilfred van IJcken

  • Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology

    Lonneke A M Gravendeel;Mathilde C M Kouwenhoven;Olivier Gevaert;Johan J de Rooi

  • Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

    Joseph Borg;Petros Papadopoulos;Marianthi Georgitsi;Laura Gutiérrez

  • New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling

    Willem A. Dik;Karin Pike-Overzet;Floor Weerkamp;Dick de Ridder;Dick de Ridder

  • The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

    Sheau Yu Hsu;Masataka Kudo;Thomas Chen;Koji Nakabayashi

  • Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

    Antoinette Hollestelle;Jord H. A. Nagel;Marcel Smid;Suzanne Lam

  • Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus.

    Damian C. Melles;Raymond F.J. Gorkink;Hélène A.M. Boelens;Susan V. Snijders

  • Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans

    Sandro Parisi;Michael J. McKay;Monika Molnar;M. Anne Thompson

  • The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

    Pieter Van Vlierberghe;Martine van Grotel;Joëlle Tchinda;Charles Lee

  • Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene.

    Leendert H.J. Looijenga;Remko Hersmus;Ad J.M. Gillis;Rolph Pfundt

  • The activin A-follistatin system: potent regulator of human extracellular matrix mineralization.

    Marco Eijken;Sigrid Swagemakers;Marijke Koedam;Cobie Steenbergen

  • The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy

    Marijana Vujkovic;Jeanne H de Vries;Jan Lindemans;Nick S Macklon;Nick S Macklon;Nick S Macklon

  • Mutations in TCF12 , encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis

    Vikram P Sharma;Aimée L Fenwick;Mia S Brockop;Mia S Brockop;Simon J McGowan

  • Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth

    Pekka Tapani Nieminen;Neil V. Morgan;Aimee L. Fenwick;Satu Parmanen

  • Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks

    George A Garinis;James R Mitchell;Michael J Moorhouse;Katsuhiro Hanada

  • Mutation in the AP4M1 Gene Provides a Model for Neuroaxonal Injury in Cerebral Palsy

    Annemieke J.M.H. Verkerk;Rachel Schot;Belinda Dumee;Karlijn Schellekens

  • Abstract 808: Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology

    Lonneke Gravendeel;Mathilde Kouwenhoven;Olivier Gevaert;Johan de Rooi

Frequent Co-Authors

Johan M. Kros
Johan M. Kros Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Eric A.P. Steegers
Eric A.P. Steegers Erasmus University Rotterdam
George P. Patrinos
George P. Patrinos University of Patras
Grazia M.S. Mancini
Grazia M.S. Mancini Erasmus University Rotterdam
Arthur A.B. Bergen
Arthur A.B. Bergen University of Amsterdam
Dirk Bootsma
Dirk Bootsma Erasmus University Rotterdam
Stephen R.F. Twigg
Stephen R.F. Twigg University of Oxford
Andrew O.M. Wilkie
Andrew O.M. Wilkie University of Oxford

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