The scientist’s investigation covers issues in Immunology, Interleukin 12, Toxoplasma gondii, Cytokine and Interleukin 10. In her work, Mycobacterium tuberculosis and Tuberculosis is strongly intertwined with Signal transduction, which is a subfield of Immunology. The study incorporates disciplines such as Tumor necrosis factor alpha, CD40, T cell, Interferon and Cell biology in addition to Interleukin 12.
Sara Hieny has included themes like Immunity and Virology in her Toxoplasma gondii study. In her study, which falls under the umbrella issue of Cytokine, Chronic infection and Antibody is strongly linked to Spleen. In her research, Microbiology, Growth inhibition, Transforming growth factor and Omega-N-Methylarginine is intimately related to Interleukin, which falls under the overarching field of Interleukin 10.
Sara Hieny mostly deals with Immunology, Schistosoma mansoni, Interleukin 12, Toxoplasma gondii and Immune system. Her Cytokine, Interleukin 10, Interferon gamma, Tumor necrosis factor alpha and Spleen study are her primary interests in Immunology. Her research in Cytokine intersects with topics in Endogeny, Lymphocyte, Tuberculosis, Mycobacterium tuberculosis and Chronic infection.
Her Interleukin 12 research focuses on Intracellular parasite and how it relates to Dendritic cell, Interferon and Pathogen. Sara Hieny interconnects T lymphocyte, CD8, Immunopathology and Cell biology in the investigation of issues within Toxoplasma gondii. Her research investigates the connection between Antibody and topics such as Antigen that intersect with issues in Cytotoxic T cell.
Her scientific interests lie mostly in Immunology, Signal transduction, Interferon gamma, Toxoplasma gondii and Immune system. In general Immunology study, her work on Cytokine often relates to the realm of Sign, thereby connecting several areas of interest. Her studies in Signal transduction integrate themes in fields like T cell, Inflammasome and Antigen.
Her research integrates issues of Receptor and Pattern recognition receptor in her study of Antigen. Her Interferon gamma research includes elements of Acquired immune system, Programmed cell death and Intracellular parasite. Her Toxoplasma gondii research is multidisciplinary, incorporating perspectives in Interleukin 12 and Toxoplasmosis.
Her main research concerns Immunology, Tuberculosis, Mycobacterium tuberculosis, Signal transduction and TRIF. Her study in the field of Immune system, Interferon gamma and Toll-like receptor is also linked to topics like Profilin. Her study in Interferon gamma is interdisciplinary in nature, drawing from both Interleukin 12, Cellular differentiation, Toxoplasma gondii and Innate immune system.
Her Tuberculosis research incorporates themes from Myeloid, Cell, Cytokine and Antigen. Her Mycobacterium tuberculosis study incorporates themes from Caspase 1 and Transgene. Her TRIF research is multidisciplinary, relying on both Endoplasmic reticulum and Cell biology.
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TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
Felix Yarovinsky;Dekai Zhang;John F. Andersen;Gerard L. Bannenberg.
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Ricardo T. Gazzinelli;M. Wysocka;S Hieny;T Scharton-Kersten.
Journal of Immunology (1996)
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.
Caetano Reis e Sousa;Sara Hieny;Tanya Scharton-Kersten;Dragana Jankovic.
Journal of Experimental Medicine (1997)
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
Ricardo T. Gazzinelli;Sara Hieny;Thomas A. Wynn;Stanley Wolf.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.
R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers.
Journal of Immunology (1994)
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.
R T Gazzinelli;F T Hakim;S Hieny;G M Shearer.
Journal of Immunology (1991)
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.
R Gazzinelli;Y Xu;S Hieny;A Cheever.
Journal of Immunology (1992)
The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta.
Ricardo T. Gazzinelli;Isabel P. Oswald;Sara Hieny;Stephanie L. James.
European Journal of Immunology (1992)
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12-and gamma interferon-dependent mechanism
Marika C. Kullberg;Jerrold M. Ward;Peter L. Gorelick;Patricia Caspar.
Infection and Immunity (1998)
Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo
Katrin D. Mayer-Barber;Daniel L. Barber;Kevin Shenderov;Sandra D. White.
Journal of Immunology (2010)
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