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Immunology

D-Index
65
Citations
20845
World Ranking
2809
National Ranking
1326

Overview

Sara Hieny is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research primarily spans the field of Medicine, with focused contributions in several subfields including Oncology, Molecular Biology, Pediatrics, Perinatology and Child Health, Critical Care and Intensive Care Medicine, and Infectious Diseases.

Their recent scholarly output includes publications with notable topics such as Heme Oxygenase-1 and Carbon Monoxide, Neonatal Health and Biochemistry, Thermal Regulation in Medicine, Cancer Immunotherapy and Biomarkers, Tuberculosis Research and Epidemiology, and Cytokine Signaling Pathways and Interactions.

Recent papers authored by Sara Hieny include the following:

  • Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection, 2020, published in Mucosal Immunology
  • Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome, 2020, published in UNC Libraries

Frequent co-authors collaborating with Sara Hieny include:

  • Alan Sher
  • Diego L. Costa
  • Eduardo P. Amaral
  • Sivaranjani Namasivayam
  • Lara Mittereder

Sara Hieny has contributed to publications in venues such as:

  • Mucosal Immunology
  • UNC Libraries

Best Publications

  • TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

    Felix Yarovinsky;Dekai Zhang;John F. Andersen;Gerard L. Bannenberg

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

    Ricardo T. Gazzinelli;M. Wysocka;S Hieny;T Scharton-Kersten

  • In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.

    Caetano Reis e Sousa;Sara Hieny;Tanya Scharton-Kersten;Dragana Jankovic

  • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

    Ricardo T. Gazzinelli;Sara Hieny;Thomas A. Wynn;Stanley Wolf

  • Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

    R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers

  • Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

    R T Gazzinelli;F T Hakim;S Hieny;G M Shearer

  • Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

    R Gazzinelli;Y Xu;S Hieny;A Cheever

  • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12-and gamma interferon-dependent mechanism

    Marika C. Kullberg;Jerrold M. Ward;Peter L. Gorelick;Patricia Caspar

  • The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta.

    Ricardo T. Gazzinelli;Isabel P. Oswald;Sara Hieny;Stephanie L. James

  • Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

    Katrin D. Mayer-Barber;Daniel L. Barber;Kevin Shenderov;Sandra D. White

  • Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection

    Katrin D. Mayer-Barber;Bruno B. Andrade;Daniel L. Barber;Sara Hieny

  • In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

    T M Scharton-Kersten;T A Wynn;E Y Denkers;S Bala

  • Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

    D L Sacks;S Hieny;A Sher

  • CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

    J Aliberti;C Reis e Sousa;M Schito;S Hieny

  • Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

    Lucia Carrera;Ricardo T. Gazzinelli;Raffaello Badolato;Sara Hieny

  • Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

    A. Alicia Koblansky;Dragana Jankovic;Hyunju Oh;Sara Hieny

  • Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

    A W Cheever;M E Williams;T A Wynn;F D Finkelman

  • In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.

    Dragana Jankovic;Marika C. Kullberg;Sara Hieny;Patricia Caspar

  • Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

    M C Kullberg;E J Pearce;S E Hieny;A Sher

  • Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

    A Sher;R L Coffman;S Hieny;A W Cheever

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal

    Ricardo Tostes Gazzinelli;Maria Wysocka;Sara Hieny;Tanya M Scharton-Kersten

Frequent Co-Authors

Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Patricia Caspar
Patricia Caspar National Institute of Allergy and Infectious Diseases
Allen W. Cheever
Allen W. Cheever National Institutes of Health
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Dragana Jankovic
Dragana Jankovic National Institute of Allergy and Infectious Diseases
Stephanie L. James
Stephanie L. James National Institute of Allergy and Infectious Diseases
Thomas A. Wynn
Thomas A. Wynn Pfizer (United States)
Carl G. Feng
Carl G. Feng University of Sydney
Werner Müller
Werner Müller University of Manchester
Ralf Kühn
Ralf Kühn Max Delbrück Center for Molecular Medicine

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