What is she best known for?
The fields of study she is best known for:
- Immune system
- Gene
- Cytokine
The scientist’s investigation covers issues in Immunology, Interleukin 12, Toxoplasma gondii, Cytokine and Interleukin 10.
In her work, Mycobacterium tuberculosis and Tuberculosis is strongly intertwined with Signal transduction, which is a subfield of Immunology.
The study incorporates disciplines such as Tumor necrosis factor alpha, CD40, T cell, Interferon and Cell biology in addition to Interleukin 12.
Sara Hieny has included themes like Immunity and Virology in her Toxoplasma gondii study.
In her study, which falls under the umbrella issue of Cytokine, Chronic infection and Antibody is strongly linked to Spleen.
In her research, Microbiology, Growth inhibition, Transforming growth factor and Omega-N-Methylarginine is intimately related to Interleukin, which falls under the overarching field of Interleukin 10.
Her most cited work include:
- TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein (859 citations)
- In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. (841 citations)
- In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. (778 citations)
What are the main themes of her work throughout her whole career to date?
Sara Hieny mostly deals with Immunology, Schistosoma mansoni, Interleukin 12, Toxoplasma gondii and Immune system.
Her Cytokine, Interleukin 10, Interferon gamma, Tumor necrosis factor alpha and Spleen study are her primary interests in Immunology.
Her research in Cytokine intersects with topics in Endogeny, Lymphocyte, Tuberculosis, Mycobacterium tuberculosis and Chronic infection.
Her Interleukin 12 research focuses on Intracellular parasite and how it relates to Dendritic cell, Interferon and Pathogen.
Sara Hieny interconnects T lymphocyte, CD8, Immunopathology and Cell biology in the investigation of issues within Toxoplasma gondii.
Her research investigates the connection between Antibody and topics such as Antigen that intersect with issues in Cytotoxic T cell.
She most often published in these fields:
- Immunology (62.07%)
- Schistosoma mansoni (33.33%)
- Interleukin 12 (28.74%)
What were the highlights of her more recent work (between 2006-2021)?
- Immunology (62.07%)
- Signal transduction (8.05%)
- Interferon gamma (17.24%)
In recent papers she was focusing on the following fields of study:
Her scientific interests lie mostly in Immunology, Signal transduction, Interferon gamma, Toxoplasma gondii and Immune system.
In general Immunology study, her work on Cytokine often relates to the realm of Sign, thereby connecting several areas of interest.
Her studies in Signal transduction integrate themes in fields like T cell, Inflammasome and Antigen.
Her research integrates issues of Receptor and Pattern recognition receptor in her study of Antigen.
Her Interferon gamma research includes elements of Acquired immune system, Programmed cell death and Intracellular parasite.
Her Toxoplasma gondii research is multidisciplinary, incorporating perspectives in Interleukin 12 and Toxoplasmosis.
Between 2006 and 2021, her most popular works were:
- Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo (363 citations)
- Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection (271 citations)
- Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. (214 citations)
In her most recent research, the most cited papers focused on:
- Immune system
- Gene
- Cytokine
Her main research concerns Immunology, Tuberculosis, Mycobacterium tuberculosis, Signal transduction and TRIF.
Her study in the field of Immune system, Interferon gamma and Toll-like receptor is also linked to topics like Profilin.
Her study in Interferon gamma is interdisciplinary in nature, drawing from both Interleukin 12, Cellular differentiation, Toxoplasma gondii and Innate immune system.
Her Tuberculosis research incorporates themes from Myeloid, Cell, Cytokine and Antigen.
Her Mycobacterium tuberculosis study incorporates themes from Caspase 1 and Transgene.
Her TRIF research is multidisciplinary, relying on both Endoplasmic reticulum and Cell biology.
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