Patricia Caspar

Overview

Best Publications

• Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

  E J Pearce;P Caspar;J M Grzych;F A Lewis

  1137
  Citations

• Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

  R T Gazzinelli;M Wysocka;S Hayashi;E Y Denkers

  875
  Citations

• Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni

  J M Grzych;E Pearce;A Cheever;Z A Caulada

  781
  Citations

• Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12-and gamma interferon-dependent mechanism

  Marika C. Kullberg;Jerrold M. Ward;Peter L. Gorelick;Patricia Caspar

  662
  Citations

• Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

  Katrin D. Mayer-Barber;Daniel L. Barber;Kevin Shenderov;Sandra D. White

  589
  Citations

• An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

  Thomas A. Wynn;Allen W. Cheever;Dragana Jankovic;Robert W. Poindexter

  587
  Citations

• Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection

  Katrin D. Mayer-Barber;Bruno B. Andrade;Daniel L. Barber;Sara Hieny

  536
  Citations

• Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis.

  Marika C. Kullberg;Dragana Jankovic;Peter L. Gorelick;Patricia Caspar

  478
  Citations

• Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

  A Sher;D Fiorentino;P Caspar;E Pearce

  438
  Citations

• Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

  A W Cheever;M E Williams;T A Wynn;F D Finkelman

  406
  Citations

• In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.

  Dragana Jankovic;Marika C. Kullberg;Sara Hieny;Patricia Caspar

  402
  Citations

• The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

  Svenja Steinfelder;John F. Andersen;Jennifer L. Cannons;Carl G. Feng

  379
  Citations

• Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile.

  Dragana Jankovic;Marika C. Kullberg;Nancy Noben-Trauth;Patricia Caspar

  356
  Citations

• NK Cell-Derived Interferon-γ Orchestrates Cellular Dynamics and the Differentiation of Monocytes into Dendritic Cells at the Site of Infection

  Romina S. Goldszmid;Pat Caspar;Aymeric Marie Christian Rivollier;Sandy White

  318
  Citations

• Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by toll-like receptor 2 (TLR2)- and TLR4-deficient animals

  Carl G. Feng;Charles A. Scanga;Carmen M. Collazo-Custodio;Allen W. Cheever

  288
  Citations

• CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

  Dragana Jankovic;Allen W. Cheever;Marika C. Kullberg;Thomas A. Wynn

  241
  Citations

• A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.

  E Y Denkers;T Scharton-Kersten;S Barbieri;P Caspar

  219
  Citations

• Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation

  Marika C. Kullberg;Antonio Gigliotti Rothfuchs;Dragana Jankovic;Patricia Caspar

  218
  Citations

• Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

  E Y Denkers;G Yap;T Scharton-Kersten;H Charest

  213
  Citations

• Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression Profile

  Dragana Jankovic;Marika C. Kullberg;Nancy Noben-Trauth;Patricia Caspar

  213
  Citations

• IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immu

  Thomas A. Wynn;Allen W. Cheever;Megan E. Williams;Sara Hieny

  0
  Citations