World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
106
Citations
58376
World Ranking
553
National Ranking
331

Medicine

D-Index
106
Citations
58359
World Ranking
6388
National Ranking
3404

Overview

Edward J. Pearce is currently affiliated with Johns Hopkins University in the United States. Their research contributions span multiple disciplines, predominantly within immunology and microbiology, biochemistry, genetics and molecular biology, and medicine. Over their career, they have published extensively across these fields.

Their work prominently focuses on immunology, with a significant number of publications related to immune cell function and interactions. Other main topics in their research include immune cells in cancer, epigenetics and DNA methylation, IL-33, ST2, and ILC pathways, cancer immunotherapy and biomarkers, cancer metabolism under hypoxia, and diabetes along with associated disorders.

Edward J. Pearce has authored papers published in a variety of scientific venues. Frequent venues for their publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cell Metabolism
  • Science Immunology
  • Immunity

Notable recent papers authored by or involving Edward J. Pearce include:

  • Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver, 2020, Immunity
  • Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH, 2021, Nature
  • Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease, 2021, Cell Metabolism
  • Triacylglycerol synthesis enhances macrophage inflammatory function, 2020, Nature Communications
  • Polyamine metabolism is a central determinant of helper T cell lineage fidelity, 2021, Cell

In terms of collaborative efforts, Edward J. Pearce frequently co-authors with several researchers, including:

  • Erika L. Pearce
  • David E. Sanin
  • Agnieszka M. Kabat
  • Katarzyna M. Grzes
  • Joy Edwards-Hicks

Their research is distributed across various subfields, mainly:

  • Immunology
  • Molecular Biology
  • Oncology
  • Epidemiology
  • Cancer Research

Best Publications

  • Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

    Chih Hao Chang;Jing Qiu;David O'Sullivan;Michael D. Buck

  • Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

    Chih-Hao Chang;Jonathan D. Curtis;Leonard B. Maggi;Brandon Faubert

  • Helminth infections: the great neglected tropical diseases

    Peter J. Hotez;Paul J. Brindley;Jeffrey M. Bethony;Charles Harding King

  • Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

    Abhishek K. Jha;Stanley Ching-Cheng Huang;Alexey Sergushichev;Alexey Sergushichev;Vicky Lampropoulou

  • Metabolic Pathways in Immune Cell Activation and Quiescence

    Erika L. Pearce;Edward J. Pearce

  • Immunometabolism governs dendritic cell and macrophage function

    Luke A.J. O’Neill;Edward J. Pearce

  • Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

    Gerritje J.W. van der Windt;Bart Everts;Chih-Hao Chang;Jonathan D. Curtis

  • Toll-like Receptor-Induced Changes in Glycolytic Metabolism Regulate Dendritic Cell Activation

    Connie M. Krawczyk;Connie M. Krawczyk;Thomas Holowka;Jie Sun;Julianna Blagih

  • The immunobiology of schistosomiasis

    Edward J. Pearce;Andrew S. MacDonald

  • Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

    Vicky Lampropoulou;Alexey Sergushichev;Monika Bambouskova;Sharmila Nair

  • Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming

    Michael D D. Buck;Michael D D. Buck;David O'Sullivan;Ramon I I. Klein Geltink;Jonathan D D. Curtis

  • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

    Stanley Ching Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

  • Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

    E J Pearce;P Caspar;J M Grzych;F A Lewis

  • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

    Bart Everts;Eyal Amiel;Stanley Ching Cheng Huang;Amber M. Smith

  • Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

    P Scott;P Natovitz;R L Coffman;E Pearce

  • Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l-Arginine Metabolism

    Matthias Hesse;Manuel Modolell;Anne C. La Flamme;Marco Schito

  • MHC class II–dependent basophil–CD4 + T cell interactions promote T H 2 cytokine–dependent immunity

    Jacqueline G Perrigoue;Steven A Saenz;Mark C Siracusa;Eric J Allenspach

  • Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development

    David O’Sullivan;Gerritje J.W. van der Windt;Stanley Ching-Cheng Huang;Jonathan D. Curtis

  • Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni

    J M Grzych;E Pearce;A Cheever;Z A Caulada

  • The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

    Gerard E. Kaiko;Stacy H. Ryu;Olivia I. Koues;Patrick L. Collins

  • Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

    Stanley Ching-Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

Frequent Co-Authors

Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Erika L. Pearce
Erika L. Pearce Max Planck Society
Stephanie L. James
Stephanie L. James National Institute of Allergy and Infectious Diseases
Andrew S. MacDonald
Andrew S. MacDonald University of Manchester
Maxim N. Artyomov
Maxim N. Artyomov Washington University in St. Louis
David Artis
David Artis Cornell University
Allen W. Cheever
Allen W. Cheever National Institutes of Health
Markus Mohrs
Markus Mohrs Trudeau Institute
Russell G. Jones
Russell G. Jones McGill University
Paul J. Brindley
Paul J. Brindley George Washington University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those interested in furthering their expertise beyond Immunology, pursuing advanced nursing degrees such as Psychiatric Mental Health Nurse Practitioner (PMHNP) programs can be a great option. Finding the right program is crucial, and students should explore the top pmhnp programs known for excellent clinical placement rates that ensure real-world experience.

Cost can often be a barrier, but there are quality options available. Prospective students may want to consider the cheapest online pmhnp programs, which offer budget-friendly routes without compromising on education quality.

Career-wise, Doctor of Nursing Practice (DNP) holders can expect competitive compensation. Understanding how much do dnps make helps in planning a sustainable career path based on geographic location and specialty.

Additionally, for nurses looking to specialize further, transitioning to acute care is an option. Resources on acute care nurse practitioner programs provide guidance on how to make this career shift efficiently.

Best Scientists Citing Edward J. Pearce

Trending Scientists

Recently Published Articles