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Erika L. Pearce

Erika L. Pearce

D-Index & Metrics

Microbiology

D-Index
65
Citations
39150
World Ranking
2456
National Ranking
182

Overview

Erika L. Pearce is affiliated with the Max Planck Society in Germany. Their research spans multiple disciplines, focusing extensively on biochemistry, genetics and molecular biology, immunology and microbiology, and medicine. This multidisciplinary approach underpins a substantial body of work on immune cell function and interaction, with particular attention to immune cells in cancer and T-cell and B-cell immunology.

Their recent publications include key papers such as "Amino Assets: How Amino Acids Support Immunity" (2020, Cell Metabolism), "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity" (2021, Cell), and "Triacylglycerol synthesis enhances macrophage inflammatory function" (2020, Nature Communications). Other notable works include "Polyamine metabolism is a central determinant of helper T cell lineage fidelity" (2021, Cell) and "Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment" (2022, Trends in Immunology).

The areas of study addressed in this body of work cover various topics including polyamine metabolism and applications, mitochondrial function and pathology, IL-33, ST2, and ILC pathways, as well as epigenetics and DNA methylation. The productivity and focus in these key topics highlight a strong presence in immunology and molecular biology subfields such as oncology, hematology, and surgery.

Erika L. Pearce frequently collaborates with a group of coauthors, reflecting ongoing partnerships in their research efforts. These coauthors include David E. Sanin, Edward J. Pearce, Joy Edwards-Hicks, Agnieszka M. Kabat, and Michal A. Stanczak.

Their work is disseminated across several prominent publication venues, with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Cell Metabolism, Cell, Nature Communications, and Nature Immunology. This publication record indicates a consistent engagement with high-impact journals in the life sciences.

  • Recent papers: "Amino Assets: How Amino Acids Support Immunity" (2020, Cell Metabolism)
  • "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity" (2021, Cell)
  • "Triacylglycerol synthesis enhances macrophage inflammatory function" (2020, Nature Communications)
  • "Polyamine metabolism is a central determinant of helper T cell lineage fidelity" (2021, Cell)
  • "Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment" (2022, Trends in Immunology)

  • Frequent coauthors: David E. Sanin
  • Edward J. Pearce
  • Joy Edwards-Hicks
  • Agnieszka M. Kabat
  • Michal A. Stanczak

  • Publication venues: bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism
  • Cell
  • Nature Communications
  • Nature Immunology

  • Main fields of study: Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology
  • Medicine

  • Subfields of study: Immunology
  • Molecular Biology
  • Oncology
  • Hematology
  • Surgery

  • Main topics of work: Immune Cell Function and Interaction
  • Immune cells in cancer
  • T-cell and B-cell Immunology
  • Polyamine Metabolism and Applications
  • Mitochondrial Function and Pathology
  • IL-33, ST2, and ILC Pathways
  • Epigenetics and DNA Methylation

Best Publications

  • Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

    Chih Hao Chang;Jing Qiu;David O'Sullivan;Michael D. Buck

  • Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

    Chih-Hao Chang;Jonathan D. Curtis;Leonard B. Maggi;Brandon Faubert

  • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

    Matthew M. Gubin;Xiuli Zhang;Heiko Schuster;Etienne Caron

  • Enhancing CD8 T-cell memory by modulating fatty acid metabolism.

    Erika L. Pearce;Matthew C. Walsh;Pedro J. Cejas;Gretchen M. Harms

  • Metabolic Pathways in Immune Cell Activation and Quiescence

    Erika L. Pearce;Edward J. Pearce

  • Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

    Gerritje J.W. van der Windt;Bart Everts;Chih-Hao Chang;Jonathan D. Curtis

  • Fueling immunity: insights into metabolism and lymphocyte function.

    Erika L. Pearce;Maya C. Poffenberger;Chih-Hao Chang;Russell G. Jones

  • Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming

    Michael D D. Buck;Michael D D. Buck;David O'Sullivan;Ramon I I. Klein Geltink;Jonathan D D. Curtis

  • T cell metabolism drives immunity

    Michael D. Buck;David O’Sullivan;Erika L. Pearce

  • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

    Stanley Ching Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

  • Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin

    Erika L. Pearce;Alan C. Mullen;Gislâine A. Martins;Connie M. Krawczyk

  • Metabolic Instruction of Immunity

    Michael D. Buck;Michael D. Buck;Ryan T. Sowell;Susan M. Kaech;Erika L. Pearce

  • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

    Bart Everts;Eyal Amiel;Stanley Ching Cheng Huang;Amber M. Smith

  • Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development

    David O’Sullivan;Gerritje J.W. van der Windt;Stanley Ching-Cheng Huang;Jonathan D. Curtis

  • Unraveling the Complex Interplay Between T Cell Metabolism and Function

    Ramon I. Klein Geltink;Ryan L. Kyle;Erika L. Pearce

  • The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

    Gerard E. Kaiko;Stacy H. Ryu;Olivia I. Koues;Patrick L. Collins

  • The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

    Julianna Blagih;François Coulombe;Emma E. Vincent;Fanny Dupuy

  • Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

    Stanley Ching-Cheng Huang;Amber M. Smith;Bart Everts;Marco Colonna

  • Metabolic switching and fuel choice during T-cell differentiation and memory development

    Gerritje J. W. van der Windt;Erika L. Pearce

  • Amino Assets: How Amino Acids Support Immunity.

    Beth Kelly;Erika L. Pearce

  • Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

    Bart Everts;Bart Everts;Eyal Amiel;Gerritje J. W. van der Windt;Gerritje J. W. van der Windt;Tori C. Freitas

  • Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

    Stanley Ching-Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

Frequent Co-Authors

Edward J. Pearce
Edward J. Pearce Johns Hopkins University
Robert Zeiser
Robert Zeiser University of Freiburg
Maxim N. Artyomov
Maxim N. Artyomov Washington University in St. Louis
Hao Shen
Hao Shen University of Pennsylvania
Russell G. Jones
Russell G. Jones McGill University
Melanie Boerries
Melanie Boerries University of Freiburg
Yongwon Choi
Yongwon Choi University of Pennsylvania
Geoffrey R. Hill
Geoffrey R. Hill Fred Hutchinson Cancer Research Center
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Oliver Kretz
Oliver Kretz Universität Hamburg

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