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121
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Overview

David P. Dearnaley is affiliated with the Institute of Cancer Research in the United Kingdom. Their research primarily focuses on medicine with a significant concentration in pulmonary and respiratory medicine, radiology, nuclear medicine and imaging, oncology, radiation, and surgery.

The scientist has contributed extensively to the study and treatment of prostate cancer, particularly in the areas of prostate cancer treatment and research, prostate cancer diagnosis and treatment, as well as advanced radiotherapy techniques. Additional areas of research include radiopharmaceutical chemistry and applications, bladder and urothelial cancer treatments, statistical methods in clinical trials, and hormonal and reproductive studies.

Frequent publication venues for their work include:

  • Journal of Clinical Oncology
  • International Journal of Radiation Oncology*Biology*Physics
  • The Lancet Oncology
  • Radiotherapy and Oncology
  • European Urology

Some of the recent papers authored or co-authored by David P. Dearnaley are:

  • NRG Oncology Updated International Consensus Atlas on Pelvic Lymph Node Volumes for Intact and Postoperative Prostate Cancer, 2020, International Journal of Radiation Oncology*Biology*Physics
  • Association of Bone Metastatic Burden With Survival Benefit From Prostate Radiotherapy in Patients With Newly Diagnosed Metastatic Prostate Cancer, 2021, JAMA Oncology
  • Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial, 2022, PLoS Medicine
  • A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study, 2021, The Lancet Oncology
  • Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol, 2023, The Lancet Oncology

David P. Dearnaley has frequently collaborated with several researchers, including:

  • Emma Hall
  • Matthew R. Sydes
  • Alison Tree
  • Nicholas D. James
  • Isabel Syndikus

Best Publications

  • Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

    Nicholas D. James;Johann S. de Bono;Melissa R. Spears;Noel W. Clarke

  • Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial

    Nicholas D. James;Nicholas D. James;Matthew R. Sydes;Noel W. Clarke;Malcolm David Mason

  • Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

    Gillian C. Barnett;Gillian C. Barnett;Charlotte E. Coles;Rebecca M. Elliott;Caroline Baynes

  • Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial

    David Dearnaley;Isabel Syndikus;Helen Mossop;Vincent Khoo

  • Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.

    Christopher C Parker;Nicholas D James;Christopher D Brawley;Noel W Clarke

  • Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven

    Gerhardt Attard;Alison H.M. Reid;Timothy A. Yap;Florence Raynaud

  • Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial

    David P Dearnaley;Matthew R Sydes;John D Graham;Edwin G Aird

  • Multiple newly identified loci associated with prostate cancer susceptibility.

    Rosalind A Eeles;Rosalind A Eeles;Zsofia Kote-Jarai;Graham G Giles;Graham G Giles;Ali Amin Al Olama

  • Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial

    David P Dearnaley;Vincent S Khoo;Andrew R Norman;Lesley Meyer

  • Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer

    Gerhardt Attard;Alison H.M. Reid;Roger A'Hern;Christopher Parker

  • Characterization of ERG, AR and PTEN Gene Status in Circulating Tumor Cells from Patients with Castration-Resistant Prostate Cancer

    Gerhardt Attard;Joost F. Swennenhuis;David Olmos;Alison H.M. Reid

  • Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

    Rosalind A. Eeles;Ali Amin Al Olama;Sara Benlloch;Edward J. Saunders

  • Cardiovascular Disease as a Long-Term Complication of Treatment for Testicular Cancer

    R.A. Huddart;A. Norman;M. Shahidi;A. Horwich

  • Intermittent Androgen Suppression for Rising PSA Level after Radiotherapy

    J. M Crook;C. J O'Callaghan;G Duncan;D. P Dearnaley

  • Hormonal impact of the 17 alpha-hydroxylase/C-17,C-20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

    A. O'Donnell;I. Judson;M. Dowsett;F. Raynaud

  • Stereotactic body radiotherapy for oligometastases.

    Alison C Tree;Vincent S Khoo;Rosalind A Eeles;Merina Ahmed

  • Significant and Sustained Antitumor Activity in Post-Docetaxel, Castration-Resistant Prostate Cancer With the CYP17 Inhibitor Abiraterone Acetate

    Alison H.M. Reid;Gerhardt Attard;Daniel C. Danila;Nikhil Babu Oommen

  • Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

    Rosalind A. Eeles;Zsofia Kote-Jarai;Ali Amin Al Olama;Graham G. Giles;Graham G. Giles

  • Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer

    Sarah L. McCarron;Stephen Edwards;Philip R. Evans;Roz Gibbs

  • Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial

    David P Dearnaley;David P Dearnaley;Gordana Jovic;Isabel Syndikus;Vincent Khoo

Frequent Co-Authors

Alan Horwich
Alan Horwich Royal Marsden NHS Foundation Trust
Chris Parker
Chris Parker Institute of Cancer Research
Robert Huddart
Robert Huddart Institute of Cancer Research
Vincent Khoo
Vincent Khoo Royal Marsden NHS Foundation Trust
Rosalind A. Eeles
Rosalind A. Eeles Institute of Cancer Research
Matthew R. Sydes
Matthew R. Sydes University College London
A. R. Norman
A. R. Norman Royal Marsden NHS Foundation Trust
Malcolm David Mason
Malcolm David Mason Cardiff University
Gerhardt Attard
Gerhardt Attard University College London
Nicholas D. James
Nicholas D. James Institute of Cancer Research

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