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Molecular Biology

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77
Citations
38703
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1089
National Ranking
565

Overview

Gerard Grosveld is a researcher affiliated with St. Jude Children's Research Hospital in the United States. Their work spans across key fields such as biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, physiology, oncology, cell biology, and immunology. Grosveld's research centers on topics including PI3K/AKT/mTOR signaling in cancer, sarcoma diagnosis and treatment, cytokine signaling pathways and interactions, calcium signaling and nucleotide metabolism, cellular transport and secretion, autophagy in disease and therapy, and protein degradation and inhibitors.

Among their recent scholarly contributions are a variety of papers published in diverse scientific venues:

  • Lysosomes and Cancer Progression: A Malignant Liaison (2021) - Frontiers in Cell and Developmental Biology
  • Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma (2022) - Science Translational Medicine
  • Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice (2022) - Communications Biology
  • Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain (2024) - bioRxiv (Cold Spring Harbor Laboratory)
  • Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain (2024) - International Journal of Molecular Sciences

The frequent publication venues for Grosveld include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Frontiers in Cell and Developmental Biology
  • Science Translational Medicine
  • Communications Biology

Grosveld collaborates regularly with several co-authors who contribute to various aspects of their research:

  • Frank C. Harwood
  • Alessandra d'Azzo
  • Jun Zhan
  • Monica Cardone
  • Diantha van de Vlekkert

Best Publications

  • The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

    Sheng Zhou;John D. Schuetz;Kevin D. Bunting;Anne-Marie Colapietro

  • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

    Groffen J;Stephenson;Heisterkamp N;de Klein A

  • AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

    Tsukasa Okuda;Jan van Deursen;Scott W Hiebert;Gerard Grosveld

  • Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF

    Takehiko Kamijo;Frederique Zindy;Martine F. Roussel;Dawn E. Quelle

  • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

    Annelies de Klein;Ad Geurts van Kessel;Gerard Grosveld;Claus R. Bartram

  • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.

    Kazuya Shimoda;Jan van Deursent;Mark Y. Sangster;Sally R. Sarawar

  • Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

    Stephan Teglund;Catriona McKay;Erin Schuetz;Jan M van Deursen

  • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

    W. E. Thierfelder;J. M. Van Deursen;K. Yamamoto;R. A. Tripp

  • Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

    Evan Parganas;Demin Wang;Dimitrios Stravopodis;David J. Topham

  • Structural organization of the bcr gene and its role in the Ph' translocation.

    Heisterkamp N;Stam K;Groffen J;de Klein A

  • Localization of the c- abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

    Nora Heisterkamp;John R. Stephenson;John Groffen;Pamela F. Hansen

  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

    Jeffrey T. Wigle;Jeffrey T. Wigle;Natasha Harvey;Michael Detmar;Irina Lagutina

  • Translocation of c- abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

    Claus R. Bartram;Annelies de Klein;Anne Hagemeijer;Ton van Agthoven

  • Defective Lymphoid Development in Mice Lacking Jak3

    Tetsuya Nosaka;Jan M. A. van Deursen;Ralph A. Tripp;William E. Thierfelder

  • TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

    Shurtleff Sa;Buijs A;Behm Fg;Rubnitz Je

  • Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

    Richard Moriggl;David J Topham;Stephan Teglund;Veronika Sexl

  • The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.

    Maarten Fornerod;Jan van Deursen;Sjozef van Baal;Albert Reynolds

  • The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

    M von Lindern;M Fornerod;S van Baal;M Jaegle

  • Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

    M von Lindern;S van Baal;J Wiegant;A Raap

  • Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

    André Hermans;Nora Heisterkamp;Marieke von Lindern;Sjozef van Baal

Frequent Co-Authors

John Groffen
John Groffen Children's Hospital of Los Angeles
Dirk Bootsma
Dirk Bootsma Erasmus University Rotterdam
Claus R. Bartram
Claus R. Bartram Heidelberg University
Nora Heisterkamp
Nora Heisterkamp Children's Hospital of Los Angeles
Annelies de Klein
Annelies de Klein Erasmus University Rotterdam
Maarten Fornerod
Maarten Fornerod Erasmus University Rotterdam
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Ellen C. Zwarthoff
Ellen C. Zwarthoff Erasmus University Rotterdam

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