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Biology and Biochemistry

D-Index
79
Citations
37708
World Ranking
4205
National Ranking
99

Overview

Ellen C. Zwarthoff is affiliated with Erasmus University Rotterdam in the Netherlands. Their research focuses largely on medicine, with significant contributions in biochemistry, genetics, and molecular biology. The primary subfields of study include surgery, molecular biology, pulmonary and respiratory medicine, urology, and biochemistry.

The scientist's main research topics cover bladder and urothelial cancer treatments, urinary and genital oncology studies, epigenetics and DNA methylation, ferroptosis and cancer prognosis, amino acid enzymes and metabolism, fibroblast growth factor research, and urological disorders and treatments.

Among recent publications, notable papers include:

  • An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer, 2021, Nature Communications
  • FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?, 2020, European Urology
  • Synchronous and metachronous urothelial carcinoma of the upper urinary tract and the bladder: Are they clonally related? A systematic review, 2020, Urologic Oncology Seminars and Original Investigations
  • Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma, 2022, European Urology
  • Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients, 2021, Urologic Oncology Seminars and Original Investigations

The frequent co-authors collaborating with Ellen C. Zwarthoff include Joost L. Boormans, Tahlita C.M. Zuiverloon, Florus C. de Jong, Egbert R. Boevé, and Kim E.M. van Kessel.

Publication venues with frequent contributions feature The Journal of Urology, European Urology Open Science, Clinical Cancer Research, Cancer Research, and European Urology.

Best Publications

  • The Immune Landscape of Cancer

    Vésteinn Thorsson;David L Gibbs;Scott D Brown;Denise Wolf

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Comprehensive Characterization of Cancer Driver Genes and Mutations.

    Matthew H Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

    A. Gordon Robertson;Jaegil Kim;Hikmat Al-Ahmadie;Joaquim Bellmunt

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

    André Kahles;Kjong-Van Lehmann;Nora C Toussaint;Matthias Hüser

  • Pathogenic Germline Variants in 10,389 Adult Cancers

    Kuan-Lin Huang;R Jay Mashl;Yige Wu;Deborah I Ritter

  • Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy

    Roland Seiler;Roland Seiler;Hussam Al Deen Ashab;Nicholas Erho;Bas W G van Rhijn

  • Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

    Jakob Hedegaard;Philippe Lamy;Iver Nordentoft;Ferran Algaba

  • Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

    Matthew H. Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

    J. A. Gossen;W. J.F. De Leeuw;C. H.T. Tan;E. C. Zwarthoff

  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

    Franz X. Schaub;Varsha Dhankani;Ashton C. Berger;Mihir Trivedi

  • The Fibroblast Growth Factor Receptor 3 (FGFR3) Mutation Is a Strong Indicator of Superficial Bladder Cancer with Low Recurrence Rate

    Bas W. G. van Rhijn;Irene Lurkin;François Radvanyi;Wim J. Kirkels

  • Molecular Grading of Urothelial Cell Carcinoma With Fibroblast Growth Factor Receptor 3 and MIB-1 is Superior to Pathologic Grade for the Prediction of Clinical Outcome

    Bas W.G. van Rhijn;André N. Vis;Theo H. van der Kwast;Wim J. Kirkels

  • FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

    Lucie C. Kompier;Irene Lurkin;Madelon N. M. van der Aa;Bas W. G. van Rhijn

  • Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

    Joshua D. Campbell;Joshua D. Campbell;Joshua D. Campbell;Christina Yau;Christina Yau;Reanne Bowlby;Yuexin Liu

  • Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

    Antoinette Hollestelle;Jord H. A. Nagel;Marcel Smid;Suzanne Lam

  • Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

    Yves Allory;Willemien Beukers;Ana Sagrera;Marta Flández

  • Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11

    A.J. Buijs;S. Sherr;S. van Baal;S. van Bezouw

Frequent Co-Authors

Arndt Hartmann
Arndt Hartmann University of Erlangen-Nuremberg
Ewout W. Steyerberg
Ewout W. Steyerberg Leiden University Medical Center
Chris H. Bangma
Chris H. Bangma Erasmus University Rotterdam
Torben F. Ørntoft
Torben F. Ørntoft Aarhus University
Francisco X. Real
Francisco X. Real Pompeu Fabra University
Núria Malats
Núria Malats Spanish National Cancer Research Centre
Jan Trapman
Jan Trapman Erasmus University Rotterdam
James W.F. Catto
James W.F. Catto University of Sheffield
Andrew D. Cherniack
Andrew D. Cherniack Broad Institute
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences

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