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Margaret A. Knowles

Margaret A. Knowles

D-Index & Metrics

Medicine

D-Index
90
Citations
26100
World Ranking
12333
National Ranking
1159

Overview

Margaret A. Knowles is affiliated with the University of Leeds in the United Kingdom. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with significant contributions in the subfields of surgery, molecular biology, pulmonary and respiratory medicine, oncology, and cancer research.

The scientist has produced numerous studies related to bladder and urothelial cancer treatments, epigenetics and DNA methylation, urinary and genital oncology studies, ferroptosis and cancer prognosis, fibroblast growth factor research, pancreatic and hepatic oncology research, and the application of 3D printing in biomedical research.

Recent publications include the following:

  • An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer, 2021, Nature Communications
  • Bladder cancer, 2023, Nature Reviews Disease Primers
  • The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets, 2021, Cancer Science
  • Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight, 2021, Cell Reports Medicine
  • Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer, 2020, The American Journal of Surgical Pathology

Frequent collaborators in these works include:

  • Carolyn D. Hurst
  • Lars Dyrskjøt
  • Julie E. Burns
  • Mattias Höglund
  • Joshua I. Warrick

Margaret A. Knowles has published extensively in venues such as the Journal of Molecular Diagnostics, Scientific Reports, Nature Communications, Nature Reviews Disease Primers, and Cancer Science.

Best Publications

  • Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

    Margaret A. Knowles;Carolyn D. Hurst

  • Lung cancer: intragenic ERBB2 kinase mutations in tumours.

    Philip Stephens;Chris Hunter;Graham Bignell;Sarah Edkins

  • Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

    Helen Davies;Chris Hunter;Raffaella Smith;Philip Stephens

  • Sequence Variant on 8q24 Confers Susceptibility to Urinary Bladder Cancer

    Lambertus A Kiemeney;Steinunn Thorlacius;Patrick Sulem;Frank Geller

  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

    Nathaniel Rothman;Montserrat Garcia-Closas;Nilanjan Chatterjee;Nuria Malats

  • IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.

    Fonnet E. Bleeker;Simona Lamba;Sieger Leenstra;Dirk Troost

  • Oncogenic FGFR3 gene fusions in bladder cancer

    Sarah V. Williams;Carolyn D. Hurst;Margaret A. Knowles

  • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

    Philip Stephens;Sarah Edkins;Helen Davies;Christopher Greenman

  • FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma

    Adel H Jebar;Carolyn D Hurst;Darren C Tomlinson;Colin Johnston

  • Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer

    James W.F. Catto;Saiful Miah;Helen C. Owen;Helen Bryant

  • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

    DC Tomlinson;O Baldo;P Harnden;MA Knowles

  • Allelotype of human bladder cancer

    Knowles Ma;Elder Pa;Williamson M;Cairns Jp

  • Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.

    Rosamonde E. Banks;Prasanna Tirukonda;Claire Taylor;Nick Hornigold

  • Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

    Margaret A. Knowles

  • A germline deletion of p14ARF but not CDKN2A in a melanoma–neural system tumour syndrome family

    Juliette A. Randerson-Moor;Mark Harland;Sarah Williams;Darren Cuthbert-Heavens

  • Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect.

    Richard D. Unwin;Rachel A. Craven;Patricia Harnden;Sarah Hanrahan

  • Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

    Fiona M. Platt;Carolyn D. Hurst;Claire F. Taylor;Walter M. Gregory

  • DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

    Joseph L Kissil;Elena Feinstein;Ofer Cohen;Peter A Jones

  • Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9.

    Cairns P;Shaw Me;Knowles Ma

  • Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

    Carolyn D Hurst;Olivia Alder;Fiona M Platt;Alastair Droop

Frequent Co-Authors

Arndt Hartmann
Arndt Hartmann University of Erlangen-Nuremberg
Peter Selby
Peter Selby University of Leeds
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
D. Timothy Bishop
D. Timothy Bishop University of Leeds
Rosamonde E. Banks
Rosamonde E. Banks University of Leeds
Maurice P. Zeegers
Maurice P. Zeegers Maastricht University
Anthony J. Gill
Anthony J. Gill University of Sydney
Frank Buntinx
Frank Buntinx KU Leuven
Unnur Thorsteinsdottir
Unnur Thorsteinsdottir deCODE Genetics (Iceland)
Giuseppe Matullo
Giuseppe Matullo University of Turin

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