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72
Citations
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World Ranking
6139
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2881

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Member of the National Academy of Sciences

Overview

Gerald F. Joyce is affiliated with the Salk Institute for Biological Studies in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with further work intersecting physics and astronomy. The subfields of study include molecular biology, astronomy and astrophysics, genetics, and physical and theoretical chemistry.

The scientist's research concentrates on topics such as RNA and protein synthesis mechanisms, origins and evolution of life, bacterial genetics and biotechnology, DNA and nucleic acid chemistry, evolution and genetic dynamics, advanced biosensing and bioanalysis techniques, and thermodynamics and calorimetric analyses.

Recent published papers from Gerald F. Joyce include the following:

  • An RNA polymerase ribozyme that synthesizes its own ancestor (2020) published in Proceedings of the National Academy of Sciences
  • Thermal Habitat for RNA Amplification and Accumulation (2020) published in Physical Review Letters
  • RNA-catalyzed evolution of catalytic RNA (2024) published in Proceedings of the National Academy of Sciences
  • Discovery of small molecules that target a tertiary-structured RNA (2022) published in Proceedings of the National Academy of Sciences
  • RNA-Catalyzed Cross-Chiral Polymerization of RNA (2020) published in Journal of the American Chemical Society

Frequent co-authors in their work include:

  • David P. Horning
  • Katrina F. Tjhung
  • Grant A. L. Bare
  • Maxim N. Shokhirev
  • Nikolaos Papastavrou

Gerald F. Joyce's publications commonly appear in the following venues:

  • Proceedings of the National Academy of Sciences
  • Journal of the American Chemical Society
  • Biochemistry
  • Physical Review Letters
  • bioRxiv (Cold Spring Harbor Laboratory)

The scientist has been recognized as a Fellow of the American Association for the Advancement of Science in 2017 and has been a member of the National Academy of Sciences since 2001.

Best Publications

  • A General Purpose RNA-Cleaving DNA Enzyme

    Stephen W. Santoro;Gerald F. Joyce

  • Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

    Debra L. Robertson;Gerald F. Joyce

  • A DNA enzyme that cleaves RNA

    Ronald R. Breaker;Gerald F. Joyce

  • Randomization of genes by PCR mutagenesis.

    R C Cadwell;G F Joyce

  • The antiquity of RNA-based evolution

    Gerald F. Joyce

  • A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron

    William M. Shih;Joel D. Quispe;Gerald F. Joyce

  • Self-Sustained Replication of an RNA Enzyme

    Tracey A. Lincoln;Gerald F. Joyce

  • RNA evolution and the origins of life

    Gerald F. Joyce

  • Directed evolution of an RNA enzyme

    Amber A. Beaudry;Gerald F. Joyce

  • Directed evolution of nucleic acid enzymes

    Gerald F. Joyce

  • A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity.

    Ronald R. Breaker;Gerald F. Joyce

  • Mechanism and utility of an RNA-cleaving DNA enzyme

    Stephen W. Santoro;Gerald F. Joyce

  • Assays and kits incorporating nucleic acid probes containing improved molecular switch

    Paul M. Lizardi;Fred R. Kramer;Sanjay Tyagi;Cesar E. Guerra

  • The Origins of the RNA World

    Michael P Robertson;Gerald F Joyce

  • Chiral selection in poly(C)-directed synthesis of oligo(G)

    G. F. Joyce;G. M. Visser;C. A. A. van Boeckel;J. H. van Boom

  • The case for an ancestral genetic system involving simple analogues of the nucleotides.

    Gerald F. Joyce;Alan W. Schwartz;Stanley L. Miller;Leslie E. Orgel

  • RNA cleavage by a DNA enzyme with extended chemical functionality.

    S W Santoro;G F Joyce;K Sakthivel;S Gramatikova

  • Enzymatic dna molecules

    Gerald F. Joyce;Ronald R. Breaker

  • Forty Years of In Vitro Evolution

    Gerald F. Joyce

  • Amplification, mutation and selection of catalytic RNA.

    Gerald F. Joyce

Frequent Co-Authors

Leslie E. Orgel
Leslie E. Orgel Salk Institute for Biological Studies
Ronald R. Breaker
Ronald R. Breaker Yale University
Sanjay Tyagi
Sanjay Tyagi Rutgers, The State University of New Jersey
Fred Russell Kramer
Fred Russell Kramer Rutgers, The State University of New Jersey
Stanley L. Miller
Stanley L. Miller University of California, San Diego
Chi-Huey Wong
Chi-Huey Wong Scripps Research Institute
K. C. Nicolaou
K. C. Nicolaou Rice University
Philip E. Dawson
Philip E. Dawson Scripps Research Institute
Dong-Eun Kim
Dong-Eun Kim Konkuk University
William M. Shih
William M. Shih Harvard Medical School

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