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Biology and Biochemistry

D-Index
129
Citations
75028
World Ranking
416
National Ranking
270

Research.com Recognitions

  • 2019 - Fellow of the Royal Society, United Kingdom
  • 2012 - Fellow, National Academy of Inventors
  • 2009 - Nobel Prize for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase
  • 2006 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - Genetics Society of America Medal
  • 1999 - Fellow of the American Academy of Arts and Sciences
  • 1998 - Member of the National Academy of Sciences

Overview

Jack W. Szostak is affiliated with the University of Chicago in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with notable work also in Physics and Astronomy. The scientist's subfields include Molecular Biology, Astronomy and Astrophysics, Genetics, Ecology, and Cellular and Molecular Neuroscience.

The main topics addressed in their work cover RNA and protein synthesis mechanisms, Origins and Evolution of Life, DNA and Nucleic Acid Chemistry, Bacterial Genetics and Biotechnology, RNA modifications and cancer, Advanced biosensing and bioanalysis techniques, and RNA Research and Splicing.

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Chemical Society, Nucleic Acids Research, Proceedings of the National Academy of Sciences, and Zenodo (CERN European Organization for Nuclear Research).

Szostak's recent papers include:

  • Template-Directed Copying of RNA by Non-enzymatic Ligation, 2020, Angewandte Chemie International Edition
  • The virtual circular genome model for primordial RNA replication, 2020, RNA
  • A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides, 2020, Journal of the American Chemical Society
  • Bulk Self-Assembly of Giant, Unilamellar Vesicles, 2020, ACS Nano
  • Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying, 2022, Proceedings of the National Academy of Sciences

Frequent co-authors include Aleksandar Radakovic, Dian Ding, Lijun Zhou, Stephanie J. Zhang, and Daniel Duzdevich.

The scientist has been recognized with several awards, such as the Nobel Prize in 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. Other distinctions include Fellowship in the Royal Society (2019), National Academy of Inventors (2012), the Albert Lasker Award for Basic Medical Research (2006), Fellowship of the American Association for the Advancement of Science (AAAS) (2006), Genetics Society of America Medal (2000), Fellowship of the American Academy of Arts and Sciences (1999), and membership in the National Academy of Sciences (1998).

Best Publications

  • In vitro selection of RNA molecules that bind specific ligands.

    Andrew D. Ellington;Jack W. Szostak

  • The double-strand-break repair model for recombination

    Jack W. Szostak;Terry L. Orr-Weaver;Rodney J. Rothstein;Franklin W. Stahl

  • Yeast transformation: a model system for the study of recombination

    Terry L. Orr-Weaver;Jack W. Szostak;Rodney J. Rothstein

  • RNA-peptide fusions for the in vitro selection of peptides and proteins

    Richard W. Roberts;Jack W. Szostak

  • In vitro selection of functional nucleic acids.

    David S. Wilson;Jack W. Szostak

  • A DNA aptamer that binds adenosine and ATP.

    David E. Huizenga;Jack W. Szostak

  • Synthesizing life : Paths to unforeseeable science & technology

    Jack W. Szostak;David P. Bartel;P. Luigi Luisi

  • Isolation of new ribozymes from a large pool of random sequences [see comment]

    David P. Bartel;Jack W. Szostak

  • A mutant with a defect in telomere elongation leads to senescence in yeast.

    Victoria Lundblad;Jack W. Szostak

  • Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.

    Elizabeth H Blackburn;Carol W Greider;Jack W Szostak

  • Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

    Andrew D. Ellington;Jack W. Szostak

  • Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division

    Martin M. Hanczyc;Shelly M. Fujikawa;Jack W. Szostak

  • An RNA motif that binds ATP

    Mandana Sassanfar;Jack W. Szostak

  • Cloning yeast telomeres on linear plasmid vectors

    Jack W. Szostak;Elizabeth H. Blackburn

  • Functional proteins from a random-sequence library

    Anthony D. Keefe;Jack W. Szostak

  • Template-directed Synthesis of a Genetic Polymer in a Model Protocell

    Sheref S. Mansy;Jason P. Schrum;Mathangi Krishnamurthy;Sylvia Tobé

  • DNA sequences of telomeres maintained in yeast

    Janis Shampay;Jack W. Szostak;Elizabeth H. Blackburn

  • Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site

    Hong Sun;Douglas Treco;Jack W. Szostak

  • Double-strand breaks at an initiation site for meiotic gene conversion

    Hong Sun;Douglas Treco;Neil P. Schultes;Jack W. Szostak

  • Construction of artificial chromosomes in yeast

    Andrew W. Murray;Jack W. Szostak

Frequent Co-Authors

Andrew W. Murray
Andrew W. Murray Harvard University
Larry W. McLaughlin
Larry W. McLaughlin Boston College
Rachel Green
Rachel Green Johns Hopkins University School of Medicine
Jon R. Lorsch
Jon R. Lorsch National Institutes of Health
Andrew D. Ellington
Andrew D. Ellington The University of Texas at Austin
Ray Wu
Ray Wu Cornell University
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Alain Nicolas
Alain Nicolas Institute Curie
Elizabeth H. Blackburn
Elizabeth H. Blackburn University of California, San Francisco

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