H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 112 Citations 58,951 286 World Ranking 392 National Ranking 259

Research.com Recognitions

Awards & Achievements

2019 - Fellow of the Royal Society, United Kingdom

2012 - Fellow, National Academy of Inventors

2009 - Nobel Prize for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase

2006 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

2006 - Fellow of the American Association for the Advancement of Science (AAAS)

2006 - Fellow of the American Association for the Advancement of Science (AAAS)

2000 - Genetics Society of America Medal

1999 - Fellow of the American Academy of Arts and Sciences

1998 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Gene
  • Enzyme

His primary scientific interests are in Biochemistry, RNA, Genetics, Ribozyme and DNA. All of his Biochemistry and Membrane, Protocell, mRNA display, Peptide and Ribosome investigations are sub-components of the entire Biochemistry study. Jack W. Szostak combines subjects such as Directed evolution, Nucleic acid and Binding site with his study of RNA.

His Binding site study deals with Binding protein intersecting with DNA Mutational Analysis, Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid, Regulatory sequence, Base pair and Transcription. His work investigates the relationship between DNA and topics such as Computational biology that intersect with problems in Sequence space. Jack W. Szostak interconnects Stereochemistry and Enzyme in the investigation of issues within Systematic evolution of ligands by exponential enrichment.

His most cited work include:

  • In vitro selection of RNA molecules that bind specific ligands. (6930 citations)
  • The double-strand-break repair model for recombination (1937 citations)
  • RNA-peptide fusions for the in vitro selection of peptides and proteins (1133 citations)

What are the main themes of his work throughout his whole career to date?

Jack W. Szostak mainly focuses on RNA, Biochemistry, Ribozyme, DNA and Genetics. The various areas that Jack W. Szostak examines in his RNA study include Nucleotide, Oligonucleotide and Stereochemistry. His Stereochemistry research is multidisciplinary, incorporating perspectives in Ribonucleotide, Phosphodiester bond and Base pair.

His study looks at the intersection of Biochemistry and topics like Biophysics with Vesicle. His studies deal with areas such as Intron and Tetrahymena as well as Ribozyme. His research combines Computational biology and Genetics.

He most often published in these fields:

  • RNA (53.40%)
  • Biochemistry (43.69%)
  • Ribozyme (22.09%)

What were the highlights of his more recent work (between 2016-2021)?

  • RNA (53.40%)
  • Nucleotide (21.36%)
  • Primer extension (17.48%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are RNA, Nucleotide, Primer extension, Oligonucleotide and Biochemistry. His work deals with themes such as Protocell, Computational biology, Stereochemistry and Monomer, which intersect with RNA. His Nucleotide research is multidisciplinary, relying on both Molecule, Phosphate, Prebiotic and Pyrimidine.

His studies in Oligonucleotide integrate themes in fields like Ligation, Biophysics, Combinatorial chemistry, Guanosine and Ribozyme. His Ribozyme study combines topics from a wide range of disciplines, such as Non-coding RNA and DNA ligase, DNA. His Biochemistry study often links to related topics such as Copying.

Between 2016 and 2021, his most popular works were:

  • Enhanced nonenzymatic RNA copying with 2-aminoimidazole activated nucleotides (84 citations)
  • Protocells and RNA Self-Replication (70 citations)
  • Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. (66 citations)

In his most recent research, the most cited papers focused on:

  • DNA
  • Gene
  • Enzyme

His scientific interests lie mostly in RNA, Nucleotide, Biochemistry, Oligonucleotide and Primer extension. The concepts of his RNA study are interwoven with issues in Protocell, Stereochemistry, DNA and Monomer. His Nucleotide research is multidisciplinary, incorporating elements of Molecule and Prebiotic.

His works in Purine metabolism and Purine are all subjects of inquiry into Biochemistry. His research in Oligonucleotide tackles topics such as Guanosine which are related to areas like Binding site and Orders of magnitude. The concepts of his Primer extension study are interwoven with issues in Combinatorial chemistry, Vesicle, Membrane and Biophysics.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

In vitro selection of RNA molecules that bind specific ligands.

Andrew D. Ellington;Jack W. Szostak.
Nature (1990)

9445 Citations

The double-strand-break repair model for recombination

Jack W. Szostak;Terry L. Orr-Weaver;Rodney J. Rothstein;Franklin W. Stahl.
Cell (1983)

2923 Citations

Yeast transformation: a model system for the study of recombination

Terry L. Orr-Weaver;Jack W. Szostak;Rodney J. Rothstein.
Proceedings of the National Academy of Sciences of the United States of America (1981)

1672 Citations

RNA-peptide fusions for the in vitro selection of peptides and proteins

Richard W. Roberts;Jack W. Szostak.
Proceedings of the National Academy of Sciences of the United States of America (1997)

1562 Citations

In vitro selection of functional nucleic acids.

David S. Wilson;Jack W. Szostak.
Annual Review of Biochemistry (1999)

1427 Citations

Synthesizing life : Paths to unforeseeable science & technology

Jack W. Szostak;David P. Bartel;P. Luigi Luisi.
Nature (2001)

1347 Citations

Isolation of new ribozymes from a large pool of random sequences [see comment]

David P. Bartel;Jack W. Szostak.
Science (1993)

1242 Citations

A DNA aptamer that binds adenosine and ATP.

David E. Huizenga;Jack W. Szostak.
Biochemistry (1995)

1226 Citations

A mutant with a defect in telomere elongation leads to senescence in yeast.

Victoria Lundblad;Jack W. Szostak.
Cell (1989)

1094 Citations

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

Andrew D. Ellington;Jack W. Szostak.
Nature (1992)

978 Citations

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