His scientific interests lie mostly in Protein tyrosine phosphatase, Biochemistry, Phosphatase, Cell biology and Signal transduction. His biological study spans a wide range of topics, including Dephosphorylation, Receptor tyrosine kinase, Differential expression, Autophosphorylation and Subcellular localization. In the subject of general Biochemistry, his work in Phosphorylation, Peptide and Stable isotope labeling by amino acids in cell culture is often linked to Leukotriene C4, thereby combining diverse domains of study.
Jeroen den Hertog combines subjects such as Protein structure, Biophysics, Activator and Proteolysis with his study of Phosphatase. His research in Cell biology intersects with topics in Genetics and Lipoxygenase. Immunology, Bone development, Synaptogenesis, Disease and Bone morphogenesis is closely connected to Mutation in his research, which is encompassed under the umbrella topic of Signal transduction.
Jeroen den Hertog mainly investigates Cell biology, Protein tyrosine phosphatase, Zebrafish, Phosphatase and Molecular biology. His Cell biology research is multidisciplinary, incorporating elements of Receptor, In vitro and Embryonic stem cell, Gene. His Protein tyrosine phosphatase study is within the categories of Biochemistry, Phosphorylation, Signal transduction and Tyrosine.
His studies in Phosphorylation integrate themes in fields like Kinase and Peptide. His Zebrafish study incorporates themes from Mutation, Protein kinase B, Regeneration and PTEN. His studies deal with areas such as Mutant, Ectodomain, Peptide sequence, Protein structure and Allosteric regulation as well as Phosphatase.
Zebrafish, Cell biology, PTEN, Protein tyrosine phosphatase and Phosphatase are his primary areas of study. His Zebrafish study incorporates themes from Mutation, Molecular biology and Protein kinase B. His Cell biology research incorporates elements of Embryonic stem cell, Small molecule and Target protein.
Signal transduction, Phosphorylation and Biochemistry are inextricably linked to his Protein tyrosine phosphatase research. The study incorporates disciplines such as Tyrosine and Phosphoproteomics in addition to Signal transduction. His Biochemistry research includes elements of Function and Resorption.
His main research concerns Protein tyrosine phosphatase, Cell biology, Stem cell, Signal transduction and Cancer research. His Protein tyrosine phosphatase study necessitates a more in-depth grasp of Phosphorylation. His Phosphorylation study contributes to a more complete understanding of Biochemistry.
The various areas that Jeroen den Hertog examines in his Cell biology study include Genetics and Zebrafish. Jeroen den Hertog interconnects Mutation and Noonan syndrome in the investigation of issues within Signal transduction. Jeroen den Hertog has included themes like PTEN, Phosphatase and Oncogenicity, Gene, Germline in his Cancer research study.
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Laminin-α4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells
Ralph Knöll;Ruben Postel;Jianming Wang;Ralph Krätzner.
Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production
Maikel P. Peppelenbosch;Leon G.J. Tertoolen;Jeroen den Hertog;Siegfried W. de Laat.
Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-|[alpha]|
Guoqiang Jiang;Jeroen den Hertog;Jing Su;Joseph Noel.
Regulation of receptor protein‐tyrosine phosphatase α by oxidative stress
Christophe Blanchetot;Leon G.J.Tertoolen;Jeroen den Hertog.
The EMBO Journal (2002)
Redox regulation of protein-tyrosine phosphatases.
Jeroen den Hertog;Arnoud Groen;Thea van der Wijk.
Archives of Biochemistry and Biophysics (2005)
RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation
Vsevolod Bodrikov;Iryna Leshchyns'ka;Vladimir Sytnyk;John Overvoorde.
Journal of Cell Biology (2005)
In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling
Paul J. Boersema;Leong Yan Foong;Vanessa M.Y. Ding;Simone Lemeer.
Molecular & Cellular Proteomics (2010)
Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface.
Guoqiang Jiang;Jeroen den Hertog;Tony Hunter.
Molecular and Cellular Biology (2000)
Protein tyrosine phosphatases: regulatory mechanisms.
Jeroen den Hertog;Arne Östman;Frank-D. Böhmer.
FEBS Journal (2008)
Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases
Camilla Persson;Tobias Sjöblom;Arnoud Groen;Kai Kappert.
Proceedings of the National Academy of Sciences of the United States of America (2004)
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