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Molecular Biology

D-Index
50
Citations
7329
World Ranking
2582
National Ranking
64

Overview

Jeroen den Hertog is affiliated with the Hubrecht Institute for Developmental Biology and Stem Cell Research in the Netherlands. Their research is situated primarily in the field of Biochemistry, Genetics and Molecular Biology, with specific focus on Molecular Biology, Immunology, Pharmacology, Genetics, and Cell Biology.

The scientist's work covers several main topics including:

  • Protein Tyrosine Phosphatases
  • Microbial Natural Products and Biosynthesis
  • Galectins and Cancer Biology
  • Bacterial biofilms and quorum sensing
  • Zebrafish Biomedical Research Applications
  • RNA modifications and cancer
  • PI3K/AKT/mTOR signaling in cancer

Frequent co-authors in their publications include Jelmer Hoeksma, Wouter A. G. Beenker, Maja Šolman, Xudong Ouyang, and Hans Clevers.

Jeroen den Hertog has regularly published in several scientific journals. The most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Frontiers in Microbiology
  • Disease Models & Mechanisms
  • Journal of Medicinal Chemistry

Selected recent papers authored or co-authored by den Hertog demonstrate a focus on protein interactions, hematopoietic function, microbial mechanisms, and zebrafish models. Notable publications include:

  • Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions, 2021, Journal of Medicinal Chemistry
  • Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects, 2022, eLife
  • Classification of antimicrobial mechanism of action using dynamic bacterial morphology imaging, 2022, Scientific Reports
  • Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism, 2020, Molecular & Cellular Proteomics
  • Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi, 2022, mBio

Best Publications

  • Laminin-α4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells

    Ralph Knöll;Ruben Postel;Jianming Wang;Ralph Krätzner

  • Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

    Maikel P. Peppelenbosch;Leon G.J. Tertoolen;Jeroen den Hertog;Siegfried W. de Laat

  • Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-|[alpha]|

    Guoqiang Jiang;Jeroen den Hertog;Jing Su;Joseph Noel

  • Redox regulation of protein-tyrosine phosphatases.

    Jeroen den Hertog;Arnoud Groen;Thea van der Wijk

  • Regulation of receptor protein‐tyrosine phosphatase α by oxidative stress

    Christophe Blanchetot;Leon G.J.Tertoolen;Jeroen den Hertog

  • In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling

    Paul J. Boersema;Leong Yan Foong;Vanessa M.Y. Ding;Simone Lemeer

  • Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface.

    Guoqiang Jiang;Jeroen den Hertog;Tony Hunter

  • RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation

    Vsevolod Bodrikov;Iryna Leshchyns'ka;Vladimir Sytnyk;John Overvoorde

  • Protein tyrosine phosphatases: regulatory mechanisms.

    Jeroen den Hertog;Arne Östman;Frank-D. Böhmer

  • Protein tyrosine phosphatases in health and disease

    Wiljan J. A. J. Hendriks;Ari Elson;Sheila Harroch;Rafael Pulido

  • Differential oxidation of protein-tyrosine phosphatases.

    Arnoud Groen;Simone Lemeer;Thea van der Wijk;John Overvoorde

  • Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity.

    Henri A. Kester;Christophe Blanchetot;Jeroen den Hertog;Paul T. van der Saag

  • Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

    Camilla Persson;Tobias Sjöblom;Arnoud Groen;Kai Kappert

  • Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

    Anna M. Blokhuis;Max Koppers;Ewout J. N. Groen;Ewout J. N. Groen;Dianne M. A. van den Heuvel

  • Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects

    Chris Jopling;Daphne van Geemen;Jeroen den Hertog

  • A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

    Emily S. Noël;Manon Verhoeven;Anne Karine Lagendijk;Anne Karine Lagendijk;Federico Tessadori

  • Chemical genetics: Drug screens in Zebrafish.

    Jeroen den Hertog

  • Dimerization of receptor protein-tyrosine phosphatase alpha in living cells.

    Leon Gj Tertoolen;Christophe Blanchetot;Guoqiang Jiang;Guoqiang Jiang;John Overvoorde

  • Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

    Alejandro Gutierrez;Alejandro Gutierrez;Ruta Grebliunaite;Hui Feng;Elena Kozakewich

  • Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide.

    Jing Yang;Arnoud Groen;Simone Lemeer;Anne Jans

Frequent Co-Authors

Leon G.J. Tertoolen
Leon G.J. Tertoolen Leiden University Medical Center
Rob M. J. Liskamp
Rob M. J. Liskamp University of Glasgow
Philippe Herbomel
Philippe Herbomel Institut Pasteur
Leonard I. Zon
Leonard I. Zon Harvard University
Arne Östman
Arne Östman Karolinska Institute
Jeroen Bakkers
Jeroen Bakkers Utrecht University
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Shabaz Mohammed
Shabaz Mohammed University of Oxford
Wiljan Hendriks
Wiljan Hendriks Radboud University Medical Center
Marco Tartaglia
Marco Tartaglia Bambino Gesù Children's Hospital

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